Latent course of liver fibrosis in patients with chronic hepatitis b: comparative evaluation of noninvasive diagnostic methods (apri, FIB-4 and fibroscan)

Mirzayeva Mehriniso Rizoyevna, Yodgorova Maqsad Shukhratovna

Klinik fanlar yilnomasi · 2025-yil

Annotatsiya

Chronic hepatitis B (CHB) remains a significant global health burden, with liver fibrosis progression being a critical determinant of patient outcomes. Traditional liver biopsy, while considered the gold standard, carries inherent risks and limitations. This study evaluates the diagnostic accuracy and clinical utility of three noninvasive methods - APRI (AST-to-Platelet Ratio Index), FIB-4 (Fibrosis-4 Index), and FibroScan (transient elastography) - in assessing liver fibrosis progression in CHB patients. A prospective cohort study of 324 CHB patients was conducted over 24 months. All patients underwent simultaneous assessment using APRI, FIB-4, and FibroScan, with liver biopsy serving as the reference standard in 156 patients. Diagnostic performance was evaluated using ROC analysis, sensitivity, specificity, and predictive values. FibroScan demonstrated superior diagnostic accuracy for significant fibrosis (≥F2) with AUROC of 0.89 (95% CI: 0.85-0.93), followed by FIB-4 (AUROC: 0.81, 95% CI: 0.76-0.86) and APRI (AUROC: 0.76, 95% CI: 0.70-0.82). The combination of FibroScan with biochemical markers improved diagnostic accuracy to 0.92 (95% CI: 0.89-0.95). FibroScan exhibits superior performance in detecting liver fibrosis in CHB patients, while combining multiple noninvasive methods enhances diagnostic accuracy and may reduce the need for invasive liver biopsy.

Maqola ma’lumotlari
MualliflarMirzayeva Mehriniso Rizoyevna, Yodgorova Maqsad Shukhratovna
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2025-10-30
Jild2
Son3/1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

Chronic hepatitis B, liver fibrosis, APRI, FIB-4, FibroScan, noninvasive assessment, Хронический гепатит B, фиброз печени, APRI, FIB-4, FibroScan, неинвазивная оценка, Surunkali gepatit B, jigar fibrozi, APRI, FIB-4, FibroScan, noinvaziv baholash

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAMirzayeva Mehriniso Rizoyevna, & Yodgorova Maqsad Shukhratovna (2025). LATENT COURSE OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B: COMPARATIVE EVALUATION OF NONINVASIVE DIAGNOSTIC METHODS (APRI, FIB-4 AND FIBROSCAN). Klinik fanlar yilnomasi, 2(3/1). https://tadqiqot.uz/index.php/spjacd/article/view/12619
GOST (OAK)Mirzayeva Mehriniso Rizoyevna, Yodgorova Maqsad Shukhratovna LATENT COURSE OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B: COMPARATIVE EVALUATION OF NONINVASIVE DIAGNOSTIC METHODS (APRI, FIB-4 AND FIBROSCAN) // Klinik fanlar yilnomasi. – 2025. – T. 2, № 3/1.
MLAMirzayeva Mehriniso Rizoyevna, and Yodgorova Maqsad Shukhratovna. “LATENT COURSE OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B: COMPARATIVE EVALUATION OF NONINVASIVE DIAGNOSTIC METHODS (APRI, FIB-4 AND FIBROSCAN).” Klinik fanlar yilnomasi, 2(3/1), 2025. https://tadqiqot.uz/index.php/spjacd/article/view/12619
ChicagoMirzayeva Mehriniso Rizoyevna, and Yodgorova Maqsad Shukhratovna. “LATENT COURSE OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B: COMPARATIVE EVALUATION OF NONINVASIVE DIAGNOSTIC METHODS (APRI, FIB-4 AND FIBROSCAN).” Klinik fanlar yilnomasi, 2(3/1) (2025). https://tadqiqot.uz/index.php/spjacd/article/view/12619
HarvardMirzayeva Mehriniso Rizoyevna, and Yodgorova Maqsad Shukhratovna (2025) ‘LATENT COURSE OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B: COMPARATIVE EVALUATION OF NONINVASIVE DIAGNOSTIC METHODS (APRI, FIB-4 AND FIBROSCAN)’, Klinik fanlar yilnomasi, 2(3/1). https://tadqiqot.uz/index.php/spjacd/article/view/12619
BibTeX
@article{mirzayevamehrinisorizoyevna2025,
  title = {LATENT COURSE OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B: COMPARATIVE EVALUATION OF NONINVASIVE DIAGNOSTIC METHODS (APRI, FIB-4 AND FIBROSCAN)},
  author = {Mirzayeva Mehriniso Rizoyevna and Yodgorova Maqsad Shukhratovna},
  journal = {Klinik fanlar yilnomasi},
  year = {2025},
  volume = {2},
  number = {3/1},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/12619}
}

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