Chronic hepatitis B (CHB) remains a significant global health burden, with liver fibrosis progression being a critical determinant of patient outcomes. Traditional liver biopsy, while considered the gold standard, carries inherent risks and limitations. This study evaluates the diagnostic accuracy and clinical utility of three noninvasive methods - APRI (AST-to-Platelet Ratio Index), FIB-4 (Fibrosis-4 Index), and FibroScan (transient elastography) - in assessing liver fibrosis progression in CHB patients. A prospective cohort study of 324 CHB patients was conducted over 24 months. All patients underwent simultaneous assessment using APRI, FIB-4, and FibroScan, with liver biopsy serving as the reference standard in 156 patients. Diagnostic performance was evaluated using ROC analysis, sensitivity, specificity, and predictive values. FibroScan demonstrated superior diagnostic accuracy for significant fibrosis (≥F2) with AUROC of 0.89 (95% CI: 0.85-0.93), followed by FIB-4 (AUROC: 0.81, 95% CI: 0.76-0.86) and APRI (AUROC: 0.76, 95% CI: 0.70-0.82). The combination of FibroScan with biochemical markers improved diagnostic accuracy to 0.92 (95% CI: 0.89-0.95). FibroScan exhibits superior performance in detecting liver fibrosis in CHB patients, while combining multiple noninvasive methods enhances diagnostic accuracy and may reduce the need for invasive liver biopsy.
| Mualliflar | Mirzayeva Mehriniso Rizoyevna, Yodgorova Maqsad Shukhratovna |
|---|---|
| Jurnal | Klinik fanlar yilnomasi |
| Nashr sanasi | 2025-10-30 |
| Jild | 2 |
| Son | 3/1 |
| Til | Ingliz |
Chronic hepatitis B, liver fibrosis, APRI, FIB-4, FibroScan, noninvasive assessment, Хронический гепатит B, фиброз печени, APRI, FIB-4, FibroScan, неинвазивная оценка, Surunkali gepatit B, jigar fibrozi, APRI, FIB-4, FibroScan, noinvaziv baholash
This study investigated the effectiveness of BAC in cognitive rehabilitation in post-stroke patients. Dynamic examination of 48 patients with cognitive impairment at the second stage of rehabilitation was performed. The…
Paclitaxel used in chemotherapy of breast cancer is an inhibitor of mitosis and is obtained from plants. They block cell division, disrupt the function of microtubules and some enzyme proteins. They change the…
This study evaluated the effect of SGLT-2 inhibitors on liver fibrosis indices (Fib-4, NAFLD fibrosis score) and insulin resistance (HOMA-IR) in patients with type 2 diabetes, as well as the correlation between these…
The development of complex pathogenetic treatment methods for TORCH infections associated with mixed infection and the improvement of differential approaches remain one of the urgent problems that need to be solved. A…
This article presents the results of a scientific study aimed at evaluating the significance and effectiveness of the Mediterranean diet in preventing exacerbations of chronic pancreatitis among the population of…
This article explores the advantages of a student-centered approach in teaching clinical pharmacology and the innovative methods for its implementation in practice. Unlike traditional teaching methods, the…
This article analyzes the clinical features of nephrotic syndrome in children, the factors influencing its development, and the ways to improve preventive measures, using the Fergana region as an example. The role of…
Currently, chemical burns of various degrees of the digestive system are a very urgent medical, social and economic problem. Severe burns of the upper gastrointestinal tract occur in 10-33% of adult patients, with a…
This study examined polymorphisms of the AGTR1 and AGTR2 genes in 153 patients with chronic kidney disease (CKD). Molecular genetic analysis revealed an increased frequency of single nucleotide polymorphisms in these…
This article explores the clinical evaluation of internal knee joint structures (menisci, ligaments, synovial membrane, etc.) using ultrasonography. The diagnostic advantages of ultrasound—such as high sensitivity…