The role of anemia in predicting outcomes of hepatorenal syndrome: clinical aspects and therapeutic strategies

Axmedova N.Sh, Jumayeva M.F

Klinik fanlar yilnomasi · 2025-yil

Annotatsiya

Hepatorenal syndrome (HRS) represents a severe complication in patients with advanced liver cirrhosis, characterized by rapid deterioration of renal function in the absence of structural kidney disease. While the pathophysiology of HRS has been extensively studied, the role of concomitant anemia as a potential prognostic factor remains inadequately characterized. This thesis investigates the relationship between anemia severity and clinical outcomes in patients with hepatorenal syndrome, examining both type 1 and type 2 HRS presentations. Through retrospective analysis of clinical data from 287 patients diagnosed with HRS between 2022-2024, this study evaluates hematological parameters, renal function markers, and survival outcomes. Results demonstrate that lower hemoglobin levels (<9 g/dL) are independently associated with increased 30-day mortality (HR 1.87, 95% CI 1.42-2.46, p<0.001) and reduced response to vasoconstrictor therapy. Furthermore, correction of anemia through targeted interventions was associated with improved renal recovery metrics. These findings establish anemia as a significant and potentially modifiable prognostic factor in HRS, suggesting that management protocols should incorporate hematological optimization alongside standard vasoconstrictive therapies to improve patient outcomes.

Maqola ma’lumotlari
MualliflarAxmedova N.Sh, Jumayeva M.F
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2025-08-12
Jild2
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

Hepatorenal syndrome, anemia, statistical analyses, Гепаторенальный синдром, анемия, статистический анализ, Gepatorenal sindrom, kamqonlik , statistik tahlillar

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAxmedova N.Sh, & Jumayeva M.F (2025). THE ROLE OF ANEMIA IN PREDICTING OUTCOMES OF HEPATORENAL SYNDROME: CLINICAL ASPECTS AND THERAPEUTIC STRATEGIES. Klinik fanlar yilnomasi, 2(1). https://tadqiqot.uz/index.php/spjacd/article/view/12082
GOST (OAK)Axmedova N.Sh, Jumayeva M.F THE ROLE OF ANEMIA IN PREDICTING OUTCOMES OF HEPATORENAL SYNDROME: CLINICAL ASPECTS AND THERAPEUTIC STRATEGIES // Klinik fanlar yilnomasi. – 2025. – T. 2, № 1.
MLAAxmedova N.Sh, and Jumayeva M.F. “THE ROLE OF ANEMIA IN PREDICTING OUTCOMES OF HEPATORENAL SYNDROME: CLINICAL ASPECTS AND THERAPEUTIC STRATEGIES.” Klinik fanlar yilnomasi, 2(1), 2025. https://tadqiqot.uz/index.php/spjacd/article/view/12082
ChicagoAxmedova N.Sh, and Jumayeva M.F. “THE ROLE OF ANEMIA IN PREDICTING OUTCOMES OF HEPATORENAL SYNDROME: CLINICAL ASPECTS AND THERAPEUTIC STRATEGIES.” Klinik fanlar yilnomasi, 2(1) (2025). https://tadqiqot.uz/index.php/spjacd/article/view/12082
HarvardAxmedova N.Sh, and Jumayeva M.F (2025) ‘THE ROLE OF ANEMIA IN PREDICTING OUTCOMES OF HEPATORENAL SYNDROME: CLINICAL ASPECTS AND THERAPEUTIC STRATEGIES’, Klinik fanlar yilnomasi, 2(1). https://tadqiqot.uz/index.php/spjacd/article/view/12082
BibTeX
@article{axmedovansh2025,
  title = {THE ROLE OF ANEMIA IN PREDICTING OUTCOMES OF HEPATORENAL SYNDROME: CLINICAL ASPECTS AND THERAPEUTIC STRATEGIES},
  author = {Axmedova N.Sh and Jumayeva M.F},
  journal = {Klinik fanlar yilnomasi},
  year = {2025},
  volume = {2},
  number = {1},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/12082}
}

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