Cerebral microangiopathy (CSVD) represents a heterogeneous group of diseases united by damage to the small vessels of the brain but having fundamentally different mechanisms of development. This work presents a comparative analysis of key mediators of neuroinflammation (IL-1β, TNF-α) and proteolysis (MMP-9) in blood and cerebrospinal fluid (CSF) in the main etiological variants of cerebral microangiopathy: hypertensive, amyloid, diabetic, and inflammatory vasculopathy. The study covered 120 patients and 30 control subjects. The obtained data demonstrate that each etiological form is characterized by a unique mediator profile. In the hypertensive form, TNF-α dominates, reflecting systemic endothelial dysfunction; in amyloid angiopathy, a specific "blood-CSF" gradient was revealed with an extreme increase in MMP-9 in the cerebrospinal fluid, correlating with the risk of hemorrhage; in the diabetic form, a systemic increase in all mediators is observed without a pronounced gradient, while in vasculitis, extremely high values indicate immune inflammation. The established patterns open new opportunities for targeted diagnosis and personalization of therapy for cerebral microangiopathy.
| Mualliflar | Адамбаев Зуфар Ибрагимович, Пазылова Аида Султановна |
|---|---|
| Jurnal | Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research |
| Nashr sanasi | 2026-05-15 |
| Jild | 7 |
| Son | 3 |
| Til | Rus |
церебральная микроангиопатия, болезнь мелких сосудов мозга, матриксные металлопротеиназы, ММП-9, провоспалительные цитокины, фактор некроза опухоли-α (TNF-α), интерлейкин-1β (IL-1β), воспалительные васкулиты, церебральная амилоидная ангиопатия, диабетическая микроангиопатия, нейровоспаление, деградация внеклеточного матрикса, эндотелиальная дисфункция, дифференциальная диагностика, внутримозговые кровоизлияния, cerebral microangiopathy, cerebral small vessel disease, matrix metalloproteinases, MMP-9, pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inflammatory vasculitis, cerebral amyloid angiopathy, diabetic microangiopathy, neuroinflammation, extracellular matrix degradation, endothelial dysfunction, differential diagnosis, intracerebral hemorrhages, miya mikroangiopatiyasi, miya kichik tomir kasalligi, matritsa metalloproteinalari, MMP-9, pro-yallashuv sitokinlari, o‘smalar nekrozi omili-α (TNF-α), interleykin-1β (IL-1β), yallashuvli vaskulitlar, miya amiloid angiopatiyasi, diabetik mikroangiopatiya, neyro-yallashuv, hujayra tashqi matritsasining degeneratsiyasi, endotelial disfunksiya, differensial diagnostika, intraserebral qon ketishlar
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