Comparative characteristics of levels of pro-inflammatory mediators and matrix metalloproteinases in various etiological forms of cerebral microangiopathy

Адамбаев Зуфар Ибрагимович, Пазылова Аида Султановна

Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2026-yil

Annotatsiya

Cerebral microangiopathy (CSVD) represents a heterogeneous group of diseases united by damage to the small vessels of the brain but having fundamentally different mechanisms of development. This work presents a comparative analysis of key mediators of neuroinflammation (IL-1β, TNF-α) and proteolysis (MMP-9) in blood and cerebrospinal fluid (CSF) in the main etiological variants of cerebral microangiopathy: hypertensive, amyloid, diabetic, and inflammatory vasculopathy. The study covered 120 patients and 30 control subjects. The obtained data demonstrate that each etiological form is characterized by a unique mediator profile. In the hypertensive form, TNF-α dominates, reflecting systemic endothelial dysfunction; in amyloid angiopathy, a specific "blood-CSF" gradient was revealed with an extreme increase in MMP-9 in the cerebrospinal fluid, correlating with the risk of hemorrhage; in the diabetic form, a systemic increase in all mediators is observed without a pronounced gradient, while in vasculitis, extremely high values indicate immune inflammation. The established patterns open new opportunities for targeted diagnosis and personalization of therapy for cerebral microangiopathy.

Maqola ma’lumotlari
MualliflarАдамбаев Зуфар Ибрагимович, Пазылова Аида Султановна
JurnalЖурнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research
NashriyotБухоро давлат тиббиёт институти
Nashr sanasi2026-05-15
Jild7
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

церебральная микроангиопатия, болезнь мелких сосудов мозга, матриксные металлопротеиназы, ММП-9, провоспалительные цитокины, фактор некроза опухоли-α (TNF-α), интерлейкин-1β (IL-1β), воспалительные васкулиты, церебральная амилоидная ангиопатия, диабетическая микроангиопатия, нейровоспаление, деградация внеклеточного матрикса, эндотелиальная дисфункция, дифференциальная диагностика, внутримозговые кровоизлияния, cerebral microangiopathy, cerebral small vessel disease, matrix metalloproteinases, MMP-9, pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inflammatory vasculitis, cerebral amyloid angiopathy, diabetic microangiopathy, neuroinflammation, extracellular matrix degradation, endothelial dysfunction, differential diagnosis, intracerebral hemorrhages, miya mikroangiopatiyasi, miya kichik tomir kasalligi, matritsa metalloproteinalari, MMP-9, pro-yallashuv sitokinlari, o‘smalar nekrozi omili-α (TNF-α), interleykin-1β (IL-1β), yallashuvli vaskulitlar, miya amiloid angiopatiyasi, diabetik mikroangiopatiya, neyro-yallashuv, hujayra tashqi matritsasining degeneratsiyasi, endotelial disfunksiya, differensial diagnostika, intraserebral qon ketishlar

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAАдамбаев Зуфар Ибрагимович, & Пазылова Аида Султановна (2026). COMPARATIVE CHARACTERISTICS OF LEVELS OF PRO-INFLAMMATORY MEDIATORS AND MATRIX METALLOPROTEINASES IN VARIOUS ETIOLOGICAL FORMS OF CEREBRAL MICROANGIOPATHY. Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(3). https://tadqiqot.uz/index.php/neurology/article/view/13811
GOST (OAK)Адамбаев Зуфар Ибрагимович, Пазылова Аида Султановна COMPARATIVE CHARACTERISTICS OF LEVELS OF PRO-INFLAMMATORY MEDIATORS AND MATRIX METALLOPROTEINASES IN VARIOUS ETIOLOGICAL FORMS OF CEREBRAL MICROANGIOPATHY // Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research. – 2026. – T. 7, № 3.
MLAАдамбаев Зуфар Ибрагимович, and Пазылова Аида Султановна. “COMPARATIVE CHARACTERISTICS OF LEVELS OF PRO-INFLAMMATORY MEDIATORS AND MATRIX METALLOPROTEINASES IN VARIOUS ETIOLOGICAL FORMS OF CEREBRAL MICROANGIOPATHY.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(3), 2026. https://tadqiqot.uz/index.php/neurology/article/view/13811
ChicagoАдамбаев Зуфар Ибрагимович, and Пазылова Аида Султановна. “COMPARATIVE CHARACTERISTICS OF LEVELS OF PRO-INFLAMMATORY MEDIATORS AND MATRIX METALLOPROTEINASES IN VARIOUS ETIOLOGICAL FORMS OF CEREBRAL MICROANGIOPATHY.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(3) (2026). https://tadqiqot.uz/index.php/neurology/article/view/13811
HarvardАдамбаев Зуфар Ибрагимович, and Пазылова Аида Султановна (2026) ‘COMPARATIVE CHARACTERISTICS OF LEVELS OF PRO-INFLAMMATORY MEDIATORS AND MATRIX METALLOPROTEINASES IN VARIOUS ETIOLOGICAL FORMS OF CEREBRAL MICROANGIOPATHY’, Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(3). https://tadqiqot.uz/index.php/neurology/article/view/13811
BibTeX
@article{article2026,
  title = {COMPARATIVE CHARACTERISTICS OF LEVELS OF PRO-INFLAMMATORY MEDIATORS AND MATRIX METALLOPROTEINASES IN VARIOUS ETIOLOGICAL FORMS OF CEREBRAL MICROANGIOPATHY},
  author = {Адамбаев Зуфар Ибрагимович and Пазылова Аида Султановна},
  journal = {Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research},
  year = {2026},
  volume = {7},
  number = {3},
  url = {https://tadqiqot.uz/index.php/neurology/article/view/13811}
}

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