Pathogenetic principles of secondary neuroprotection in patients with closed craniocerebral injuries. (Review article)

Ibragimov N.K., Kenjaev L.T., Ибрагимов Н.К., Кенжаев Л.Т., Ibragimov N.K., Kenjaev L.T.

Research Focus · 2025-yil

Annotatsiya

Closed craniocerebral injury is the main cause of death and severe disability throughout the world. The treatment and rehabilitation of its victims inflict great damage on the budgets of various countries. The psychological and physical burden, the decline in the quality of life and the considerable expenditure can only underline the need for additional, more complex and effective options for managing these patients. The concept of neuroprotection, as a means of achieving a better outcome by making use of the complex pathophysiological changes provoked by ischaemia, has been and remains at the centre of many therapeutic and surgical strategies. Several types of complication that give rise to the various mechanisms of closed craniocerebral injury, from excitotoxicity, apoptosis and oxidative stress to inflammation, have been studied, and most of them have led to disappointment at the clinical stage; at every stage of damage, protection, that is neuroprotection, must be provided in order to prevent one or another pathway of damage or to minimise its consequences. This shows that neuroprotection remains an important treatment tactic. This review gives brief information on the clinically studied methods of neuroprotection, their mechanisms and results, the potential targets of neuroprotection and targeted methods of treatment.

Maqola ma’lumotlari
MualliflarIbragimov N.K., Kenjaev L.T., Ибрагимов Н.К., Кенжаев Л.Т., Ibragimov N.K., Kenjaev L.T.
JurnalResearch Focus
NashriyotВетеринария ИТИ ва “Илм-фан ва инновациялар академияси” МЧЖ
ISSN2181-3833
Nashr sanasi2025-03-05
Jild4
Son2
Betlar123-136
TilIngliz
Ilmiy sohaVeterinariya
DOI10.66073/researchfocus.v4i2.1337
Indeksga qo‘shilgan2026-09-12

DOI: 10.66073/researchfocus.v4i2.1337 · Maqolaning asl sahifasi

Kalit so‘zlar

neyroproteksiya, yopiq bosh miya jarohati, apoptoz, yallig‘lanish, eksitotoksiklik, oksidlovchi stress, kallidinogenaza, neuroprotection, closed craniocerebral injury, apoptosis, inflammation, excitotoxicity, oxidative stress, kallidinogenase, нейропротекция, закрытая черепно-мозговая травма, апоптоз, воспаление, эксайтотоксичность, окислительный стресс, каллидиногеназа

Ilmiy soha

Veterinariya

Iqtibos keltirish

APAIbragimov N.K., Kenjaev L.T., Ибрагимов Н.К., Кенжаев Л.Т., Ibragimov N.K., & Kenjaev L.T. (2025). PATHOGENETIC PRINCIPLES OF SECONDARY NEUROPROTECTION IN PATIENTS WITH CLOSED CRANIOCEREBRAL INJURIES. (Review article). Research Focus, 4(2), 123-136. https://doi.org/10.66073/researchfocus.v4i2.1337
GOST (OAK)Ibragimov N.K. va b. PATHOGENETIC PRINCIPLES OF SECONDARY NEUROPROTECTION IN PATIENTS WITH CLOSED CRANIOCEREBRAL INJURIES. (Review article) // Research Focus. – 2025. – T. 4, № 2. – P. 123-136. – DOI: 10.66073/researchfocus.v4i2.1337.
MLAIbragimov N.K., Kenjaev L.T., Ибрагимов Н.К., Кенжаев Л.Т., Ibragimov N.K., and Kenjaev L.T. “PATHOGENETIC PRINCIPLES OF SECONDARY NEUROPROTECTION IN PATIENTS WITH CLOSED CRANIOCEREBRAL INJURIES. (Review article).” Research Focus, 4(2), 123-136, 2025. https://doi.org/10.66073/researchfocus.v4i2.1337
ChicagoIbragimov N.K., Kenjaev L.T., Ибрагимов Н.К., Кенжаев Л.Т., Ibragimov N.K., and Kenjaev L.T. “PATHOGENETIC PRINCIPLES OF SECONDARY NEUROPROTECTION IN PATIENTS WITH CLOSED CRANIOCEREBRAL INJURIES. (Review article).” Research Focus, 4(2), 123-136 (2025). https://doi.org/10.66073/researchfocus.v4i2.1337
HarvardIbragimov N.K., Kenjaev L.T., Ибрагимов Н.К., Кенжаев Л.Т., Ibragimov N.K., and Kenjaev L.T (2025) ‘PATHOGENETIC PRINCIPLES OF SECONDARY NEUROPROTECTION IN PATIENTS WITH CLOSED CRANIOCEREBRAL INJURIES. (Review article)’, Research Focus, 4(2), 123-136. https://doi.org/10.66073/researchfocus.v4i2.1337
BibTeX
@article{ibragimovnk2025,
  title = {PATHOGENETIC PRINCIPLES OF SECONDARY NEUROPROTECTION IN PATIENTS WITH CLOSED CRANIOCEREBRAL INJURIES. (Review article)},
  author = {Ibragimov N.K. and Kenjaev L.T. and Ибрагимов Н.К. and Кенжаев Л.Т. and Ibragimov N.K. and Kenjaev L.T.},
  journal = {Research Focus},
  year = {2025},
  volume = {4},
  number = {2},
  pages = {123-136},
  doi = {10.66073/researchfocus.v4i2.1337},
  url = {https://doi.org/10.66073/researchfocus.v4i2.1337}
}

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