Properties of hyaluronic acid and mechanisms of influence on aging processes

Matkarimova Nigora Sagdullayevna, Abdullayeva Dilshoda To'yboy qizi, Latipova Iroda Isomiddinovna, Turabjanova Saodat Shavkatovna, Маткаримова Нигора Сагдуллаевна, Абдуллаева Дилшода Туйбой кизи, Латипова Ирода Исомиддиновна, Турабжанова Саодат Шавкатовна, Matkarimova Nigora Sagdullayevna, Abdullayeva Dilshoda To'yboy qizi, Latipova Iroda Isomiddinovna, Turabjanova Saodat Shavkatovna

Research Focus · 2024-yil

Annotatsiya

Hyaluronic acid (HA), hyaluronate or hyaluronan is an organic compound belonging to the group of non-sulfated glucosaminoglycans. This compound is an anionic linear polysaccharide with a molecular weight from 105 to 107 daltons, depending on the method of its production. HA is an important component of the human body. Its biologically active functions include participation in the processes of cell migration, proliferation and differentiation; regeneration and maintenance of the water balance of tissues; participation in a number of interactions with cell surface receptors; and ensuring the necessary viscosity of the synovial fluid and the elasticity of articular cartilage. The aim of the present study was to find out whether collagen degradation causes inhibition of HA synthesis in human skin fibroblasts. Thus, a new mechanism is presented of how proteolytic cleavage of collagen can inhibit HA synthesis in dermal fibroblasts during extrinsic skin ageing. It is a polymer of glycosaminoglycans present in embryogenesis and in tissues undergoing repair. It is responsible for the water content of the skin, where half of the body's hyaluronic acid is present. As in other tissues, it undergoes rapid turnover. Its biology differs greatly between the dermis and the epidermis. Levels do not decline with age, but instead become increasingly bound to tissues and resistant to extraction in vitro. Hyaluronan-binding proteins are involved, most of which remain unidentified. The size of hyaluronic acid is of decisive importance for its various functions. A high molecular size reflects intact tissues and antiangiogenic and immunosuppressive properties, while smaller polymers are distress signals and powerful inducers of inflammation and angiogenesis.

Maqola ma’lumotlari
MualliflarMatkarimova Nigora Sagdullayevna, Abdullayeva Dilshoda To'yboy qizi, Latipova Iroda Isomiddinovna, Turabjanova Saodat Shavkatovna, Маткаримова Нигора Сагдуллаевна, Абдуллаева Дилшода Туйбой кизи, Латипова Ирода Исомиддиновна, Турабжанова Саодат Шавкатовна, Matkarimova Nigora Sagdullayevna, Abdullayeva Dilshoda To'yboy qizi, Latipova Iroda Isomiddinovna, Turabjanova Saodat Shavkatovna
JurnalResearch Focus
NashriyotВетеринария ИТИ ва “Илм-фан ва инновациялар академияси” МЧЖ
ISSN2181-3833
Nashr sanasi2024-02-05
Jild3
Son1
Betlar20-25
TilIngliz
Ilmiy sohaVeterinariya
DOI10.66073/researchfocus.v3i1.670
Indeksga qo‘shilgan2026-09-08

DOI: 10.66073/researchfocus.v3i1.670 · Maqolaning asl sahifasi

Kalit so‘zlar

старение, фотостарение, хронологическое старение, пигментации, гиалуроновая, aging, photoaging, chronological aging, pigmentation, hyaluronic, qarish, fotoqarish, xronologik qarish, pigmentatsiya, gialuron

Ilmiy soha

Veterinariya

Iqtibos keltirish

APAMatkarimova Nigora Sagdullayevna, Abdullayeva Dilshoda To'yboy qizi, Latipova Iroda Isomiddinovna, Turabjanova Saodat Shavkatovna, Маткаримова Нигора Сагдуллаевна, Абдуллаева Дилшода Туйбой кизи, Латипова Ирода Исомиддиновна, Турабжанова Саодат Шавкатовна, Matkarimova Nigora Sagdullayevna, Abdullayeva Dilshoda To'yboy qizi, Latipova Iroda Isomiddinovna, & Turabjanova Saodat Shavkatovna (2024). PROPERTIES OF HYALURONIC ACID AND MECHANISMS OF INFLUENCE ON AGING PROCESSES. Research Focus, 3(1), 20-25. https://doi.org/10.66073/researchfocus.v3i1.670
GOST (OAK)Matkarimova Nigora Sagdullayevna va b. PROPERTIES OF HYALURONIC ACID AND MECHANISMS OF INFLUENCE ON AGING PROCESSES // Research Focus. – 2024. – T. 3, № 1. – P. 20-25. – DOI: 10.66073/researchfocus.v3i1.670.
MLAMatkarimova Nigora Sagdullayevna, Abdullayeva Dilshoda To'yboy qizi, Latipova Iroda Isomiddinovna, Turabjanova Saodat Shavkatovna, Маткаримова Нигора Сагдуллаевна, Абдуллаева Дилшода Туйбой кизи, Латипова Ирода Исомиддиновна, Турабжанова Саодат Шавкатовна, Matkarimova Nigora Sagdullayevna, Abdullayeva Dilshoda To'yboy qizi, Latipova Iroda Isomiddinovna, and Turabjanova Saodat Shavkatovna. “PROPERTIES OF HYALURONIC ACID AND MECHANISMS OF INFLUENCE ON AGING PROCESSES.” Research Focus, 3(1), 20-25, 2024. https://doi.org/10.66073/researchfocus.v3i1.670
ChicagoMatkarimova Nigora Sagdullayevna, Abdullayeva Dilshoda To'yboy qizi, Latipova Iroda Isomiddinovna, Turabjanova Saodat Shavkatovna, Маткаримова Нигора Сагдуллаевна, Абдуллаева Дилшода Туйбой кизи, Латипова Ирода Исомиддиновна, Турабжанова Саодат Шавкатовна, Matkarimova Nigora Sagdullayevna, Abdullayeva Dilshoda To'yboy qizi, Latipova Iroda Isomiddinovna, and Turabjanova Saodat Shavkatovna. “PROPERTIES OF HYALURONIC ACID AND MECHANISMS OF INFLUENCE ON AGING PROCESSES.” Research Focus, 3(1), 20-25 (2024). https://doi.org/10.66073/researchfocus.v3i1.670
HarvardMatkarimova Nigora Sagdullayevna, Abdullayeva Dilshoda To'yboy qizi, Latipova Iroda Isomiddinovna, Turabjanova Saodat Shavkatovna, Маткаримова Нигора Сагдуллаевна, Абдуллаева Дилшода Туйбой кизи, Латипова Ирода Исомиддиновна, Турабжанова Саодат Шавкатовна, Matkarimova Nigora Sagdullayevna, Abdullayeva Dilshoda To'yboy qizi, Latipova Iroda Isomiddinovna, and Turabjanova Saodat Shavkatovna (2024) ‘PROPERTIES OF HYALURONIC ACID AND MECHANISMS OF INFLUENCE ON AGING PROCESSES’, Research Focus, 3(1), 20-25. https://doi.org/10.66073/researchfocus.v3i1.670
BibTeX
@article{matkarimovanigorasagdullayevna2024,
  title = {PROPERTIES OF HYALURONIC ACID AND MECHANISMS OF INFLUENCE ON AGING PROCESSES},
  author = {Matkarimova Nigora Sagdullayevna and Abdullayeva Dilshoda To'yboy qizi and Latipova Iroda Isomiddinovna and Turabjanova Saodat Shavkatovna and Маткаримова Нигора Сагдуллаевна and Абдуллаева Дилшода Туйбой кизи and Латипова Ирода Исомиддиновна and Турабжанова Саодат Шавкатовна and Matkarimova Nigora Sagdullayevna and Abdullayeva Dilshoda To'yboy qizi and Latipova Iroda Isomiddinovna and Turabjanova Saodat Shavkatovna},
  journal = {Research Focus},
  year = {2024},
  volume = {3},
  number = {1},
  pages = {20-25},
  doi = {10.66073/researchfocus.v3i1.670},
  url = {https://doi.org/10.66073/researchfocus.v3i1.670}
}

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