The role of hyperhomocysteinemia in the pathogenesis of post-traumatic encephalopathy

Хайдаров Нодир Қодирович, Хикматова Шахзода Шухратовна, Собирова Саодат Кароматовна

Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-yil

Annotatsiya

Post-traumatic encephalopathy (PTE) is one of the most frequent and socially significant consequences of craniocerebral trauma, accompanied by cognitive and emotional impairments. In recent years, special attention has been paid to the study of biochemical markers that reflect the severity of the pathological process and the prognosis of recovery. The aim of the study was to determine the role of hyperhomocysteinemia in the pathogenesis of PTE and its relationship with cognitive impairments. 60 patients treated at the Tashkent Regional Specialized Somatic Hospital were examined. Men predominated in the study sample (66.6%). All patients underwent blood homocysteine levels and neuropsychological testing using the MMSE and MoCA scales. It has been established that higher levels of homocysteine are associated with more pronounced cognitive deficit. A negative correlation was found between homocysteine concentration and cognitive test results. The obtained data confirm the role of hyperhomocysteinemia as a significant biomarker of post-traumatic encephalopathy and indicate the need to determine it in a comprehensive examination of patients.

Maqola ma’lumotlari
MualliflarХайдаров Нодир Қодирович, Хикматова Шахзода Шухратовна, Собирова Саодат Кароматовна
JurnalЖурнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research
NashriyotБухоро давлат тиббиёт институти
Nashr sanasi2025-10-16
Jild6
Son6
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

посттравматическая энцефалопатия; черепно-мозговая травма; гипергомоцистеинемия; когнитивные нарушения; биохимические маркеры; Mini-Mental State Examination (MMSE); Montreal Cognitive Assessment (MoCA), post-traumatic encephalopathy; craniocerebral trauma; hyperhomocysteinemia; cognitive impairments; biochemical markers; Mini- Mental State Examination (MMSE); Montreal Cognitive Assessment (MoCA), посттравматик энцефалопатия; бош мия жароҳати; гипергомотсистеинемия; когнитив бузилишлар; биокимёвий маркерлар; Mini-Mental State Examination (ММСЕ); Montreal Cognitive Assessment (МоCА).

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Iqtibos keltirish

APAХайдаров Нодир Қодирович, Хикматова Шахзода Шухратовна, & Собирова Саодат Кароматовна (2025). THE ROLE OF HYPERHOMOCYSTEINEMIA IN THE PATHOGENESIS OF POST-TRAUMATIC ENCEPHALOPATHY. Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6). https://tadqiqot.uz/index.php/neurology/article/view/12556
GOST (OAK)Хайдаров Нодир Қодирович, Хикматова Шахзода Шухратовна, Собирова Саодат Кароматовна THE ROLE OF HYPERHOMOCYSTEINEMIA IN THE PATHOGENESIS OF POST-TRAUMATIC ENCEPHALOPATHY // Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research. – 2025. – T. 6, № 6.
MLAХайдаров Нодир Қодирович, Хикматова Шахзода Шухратовна, and Собирова Саодат Кароматовна. “THE ROLE OF HYPERHOMOCYSTEINEMIA IN THE PATHOGENESIS OF POST-TRAUMATIC ENCEPHALOPATHY.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6), 2025. https://tadqiqot.uz/index.php/neurology/article/view/12556
ChicagoХайдаров Нодир Қодирович, Хикматова Шахзода Шухратовна, and Собирова Саодат Кароматовна. “THE ROLE OF HYPERHOMOCYSTEINEMIA IN THE PATHOGENESIS OF POST-TRAUMATIC ENCEPHALOPATHY.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6) (2025). https://tadqiqot.uz/index.php/neurology/article/view/12556
HarvardХайдаров Нодир Қодирович, Хикматова Шахзода Шухратовна, and Собирова Саодат Кароматовна (2025) ‘THE ROLE OF HYPERHOMOCYSTEINEMIA IN THE PATHOGENESIS OF POST-TRAUMATIC ENCEPHALOPATHY’, Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6). https://tadqiqot.uz/index.php/neurology/article/view/12556
BibTeX
@article{article2025,
  title = {THE ROLE OF HYPERHOMOCYSTEINEMIA IN THE PATHOGENESIS OF POST-TRAUMATIC ENCEPHALOPATHY},
  author = {Хайдаров Нодир Қодирович and Хикматова Шахзода Шухратовна and Собирова Саодат Кароматовна},
  journal = {Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research},
  year = {2025},
  volume = {6},
  number = {6},
  url = {https://tadqiqot.uz/index.php/neurology/article/view/12556}
}

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