Meningiomas account for 30-35% of primary intracranial tumors in adults and are 1.8-2 times more common in women. Most Grade I tumors grow slowly, but up to 25% of Grade II-III tumors show atypia, deep invasion, and a high risk of recurrence. The proliferative index of Ki-67 and the microvascular density of CD34 reliably reflect the aggressiveness of meningiomas, and the depth of invasion ≥ 3 mm and incomplete resection according to Simpson increase the risk of tumor return. However, the effect of these markers on functional recovery (ΔKPS, ΔFIM) after surgery has not been sufficiently studied, and there is no single prognostic model for rehabilitation potential yet. Materials and methods. The study included 124 patients (mean age 56 ± 12 years; 61% women) operated on intracranial meningiomas in the period 2019-2024. Functional status was assessed before surgery and after 3 months using the Karnofsky Performance Status (KPS) scale (Mor et al., 1984) [13] and the Functional Independence Measure (FIM) scale (Keith et al., 1987) [8]; in this case, the increments of ΔKPS and ΔFIM were calculated. The histological grade of the tumor was determined according to the 2021 WHO classification. Using immunohistochemistry according to the protocol of Baay et al. (2018) [1], the Ki-67 proliferation index was assessed, and according to the method of Zhou et al. (2018) [21] - microvascular density (CD34, vascular/HPF). The depth of invasion into the brain was measured microscopically: ≥ 3 mm was considered significant (Behling et al., 2021) [2]. The degree of radical removal was classified according to the Simpson I-V scale (EANO, Marosi et al., 2008) [12]. Multivariate logistic regression analysis was used to identify independent factors associated with high rehabilitation potential (ΔKPS ≥ 15 and ΔFIM ≥ 20). <0,05. Outcomes. ΔKPS and ΔFIM were significantly dependent on tumor grade: the median increase in KPS was +18 at Grade I, +11 at Grade II, and +4 at Grade III (p < 0.001); ΔFIM - +25, +14 and +6, respectively (p < 0.001). High RP (ΔKPS ≥ 15 and ΔFIM ≥ 20) was achieved in 73% of patients Grade I, 34,5 % - Grade II и 10,1 % — Grade III (p < 0,001). Independent predictors of high RP were: Ki-67 < 4% (OR = 4.6; p = 0.001), CD34 < 12 vessels/HPF (OR = 2.9; p = 0.008), Simpson I-II resection (OR = 2,5; p = 0,027) and the absence of diffuse invasion(OR = 3,2; p = 0,005). Conclusion: Low Ki-67 and CD34 values, radical resection and the absence of deep invasion serve as reliable markers of high rehabilitation potential. Taking them into account will make it possible to personalize the postoperative rehabilitation plan and improve recovery indicators in patients with intracranial meningiomas.
| Mualliflar | Равшанов Даврон Мавлонович, Мавлянова Зилола Фархадовна, Ашуров Рустамжон Фуркатович |
|---|---|
| Jurnal | Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research |
| Nashr sanasi | 2025-09-12 |
| Jild | 6 |
| Son | 5 |
| Til | Rus |
менингиома; Ki-67; CD34; инвазия в мозг; резекция по Симпсону; Karnofsky Performance Status; Functional Independence Measure; реабилитационный потенциал., meningioma; Ki-67; CD34; invasion of the brain; Simpson resection; Karnofsky Performance Status; Functional Independence Measure; rehabilitation potential., менингиома; Ki-67; CD34; мияга инвазия; Симпсон бўйича резекция; Karnofsky Performance Status; Functional Independence Measure; реабилитация салоҳияти.
Subclinical hypothyroidism is a widespread endocrine disorder that often remains undiagnosed. The latent course of this condition, especially its manifestation through neurological symptoms, has garnered increasing…
This scientific study investigates the relationship between post-stroke speech disorders and the neurological status of patients as a factor influencing speech function. The research was conducted between 2021 and 2024…
A total of 100 patients with Parkinson’s disease at stages I–III according to the Hoehn and Yahr scale, receiving outpatient care, were examined. All patients underwent comprehensive clinical-neurological and…
The treatment of vertebrobasilar insufficiency (VBI) remains one of the most urgent problems in modern medicine. VBI—a common form of cerebrovascular disorder—represents a reversible ischemia of brain structures…
This article discusses how physical exercise can support brain recovery and improve functions in neurodegenerative diseases. The research findings confirm that physical activity increases growth factors in the brain and…
The main pathogenetic factors in the development of chronic cerebral ischemia are atherosclerotic vascular changes and arterial hypertension, which are observed in the overwhelming majority of cases (95–97%). Recent…
The purpose of the study is to evaluate the quality of life of patients with acromegaly and secondary syndrome of the "empty" Turkish saddle using the Acro-Col questionnaire. Material and research methods. On the basis…
The study included 107 patients (60 women and 47 men) aged 35 to 60 years who presented with complaints of paresthesia, pain, and weakness in the hand. All participants underwent clinical tests (Phalen, Tinel, Durkan)…
The article presents the results of study of efficacy of intranasal electrophoresis with ceruloplasmin and a course of iodinebromine baths in patients with primary forms of cerebrovascular diseases. Application of…
Ишемический инсульт (ИИ) представляет собой одно из наиболее серьезных заболеваний, вызывающих значительную смертность и инвалидизацию населения по всему миру. В последние десятилетия наблюдается рост заболеваемости…