Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia, and inhibition of α-glucosidase is considered an effective approach for reducing postprandial blood glucose levels. The present study aimed to comparatively evaluate the in vitro α-glucosidase inhibitory activity of grape (Vitis vinifera), fig (Ficus carica), and blueberry (Vaccinium caesariense) extracts and to investigate their potential as natural antidiabetic agents. Fruit extracts were prepared by homogenization, centrifugation, filtration, pasteurization, and dilution. The inhibitory activity was determined spectrophotometrically using p-nitrophenyl-α-D-glucopyranoside (pNPG) as the substrate, while acarbose served as the positive control. Among the tested samples, grape extract exhibited the highest inhibitory activity (43.31 ± 1.97%), followed by fig (29.47 ± 1.97%) and blueberry (15.96 ± 3.95%). The IC₅₀ value of acarbose was estimated to be approximately 0.53 mg/mL. Enzyme kinetic analysis based on the Lineweaver–Burk plot indicated that grape extract inhibited α-glucosidase predominantly through a competitive inhibition mechanism. These findings demonstrate that the tested fruit extracts contain bioactive compounds capable of inhibiting α-glucosidase activity, with grape extract showing the greatest inhibitory potential. Therefore, these fruits may serve as promising natural sources of bioactive compounds for the development of functional foods and complementary strategies for the management of postprandial hyperglycemia.
| Mualliflar | Shohrukh, Shukurov Bahriddin o'g'li, Robiya, Razzokova Botir qizi |
|---|---|
| Jurnal | Қўқон ДПИ. Илмий хабарлар |
| Nashr sanasi | 2026-08-10 |
| Jild | 8 |
| Son | 07 |
| Betlar | 99-105 |
| Til | Ingliz |
| DOI | 10.70728/a.series.tab.v08.i07.013 |
DOI: 10.70728/a.series.tab.v08.i07.013 · Maqolaning asl sahifasi
α-glucosidase, fruit extracts, grape, fig, blueberry, enzyme inhibition, diabetes mellitus, acarbose, polyphenols.
Ushbu maqolada Fargʻona viloyati sharoitida shakllangan qishloq xoʻjaligi ekinlari va ularga xos oʻsimlik turlarining bioekologik, morfologik hamda xoʻjalik ahamiyati oʻrganilgan. Fargʻona vodiysi tuproq-iqlim…
Global oziq-ovqat xavfsizligini ta’minlash qishloq xo’jaligi oldida turgan eng dolzarb vazifalardan biridir. Ushbu vazifani bajarishda bug’doy (Triticum aestivum L.) muhum strategik ahamiyatga ega oziq-ovqat ekinlaridan…
Ushbu maqolada Sirdaryo viloyatidagi sug‘oriladigan soz tuproqning 0- 80 sm kesimidagi qatlamlari bo‘yicha namlik, pH, elektr o‘tkazuvchanlik, suvda eruvchan tuzlar va oziqa elementlari taqsimoti tahlil qilindi. Tuproq…
Drought stress is one of the major abiotic factors limiting tomato (Solanum lycopersicum L.) production in many agricultural regions worldwide. The identification of drought-tolerant genetic resources is therefore an…
Ushbu maqolada arab she'riyatining eng muhim tarkibiy elementlaridan biri — vazn (aruz) va qofiya (qofiya) tizimi keng qamrovli ilmiy tahlil etiladi. Arab aruz ilmi VIII asrda al- Xalil ibn Ahmad al-Farahidiy tomonidan…
Mazkur tadqiqotda rovoch (Rheum maximowiczii) bargi, jusay (Allium odorum)ning yer ustki qismi hamda ularning 3:1 og‘irlik nisbatidagi aralshmasi asosida tayyorlangan “As Rheum” (OOQ) tarkibidagi erkin aminokislotalar…
A Ni(II) mixed-ligand complex has been synthesized from a nickel(II) nitrate hexahydrate salt, neocuproine and urea in solution, and characterized by FT-IR spectroscopy and powder X-ray diffraction. The IR spectrum…
Orol dengizi havzasi yuqori sho‘rlanish va keskin ekologik o‘zgarishlar natijasida shakllangan ekstremal ekotizimlardan biri hisoblanadi. Ushbu tadqiqotda G‘arbiy Orol dengizi suvlari, Sudoche ko‘li cho‘kindilari va…
EDXRF usulida O‘zbekistonning uchta sanoat hududi (Forish tumani sement-ohak zavodlari, Olmaliq KMK hududi, Qoratov massivi) tuprog‘i hamda ularda o‘sadigan moxlar (Funaria hygrometrica, Grimmia tergestina, G…
Ushbu tadqiqot ishida akril sopolimerlari va suyuq shisha gibrid bog‘lovchisi hamda mineral to‘ldirgichlar asosida issiqlikka chidamli kompozitsion qoplamalar olish texnologiyasi ishlab chiqilgan. Tadqiqotning maqsadi…