Aim of the study: analysis of the structure of the AZF locus of the Y chromosome in boys and adolescents with disorders of sexual development. Materials and research methods. The study was conducted on a large sample of 488 children with disorders of sexual development; the AZF gene was analyzed in 26 boys and adolescents; a general clinical, general and special andrological study was carried out. The volume of the testicles was measured using a Prader orchidometer. Stages of puberty were assessed according to the Tanner classification, determination of blood levels of testosterone, follicle-stimulating and luteinizing hormones. Molecular genetic analysis to detect AZF deletions on the Y chromosome was carried out using the following STS markers: AZFa: sY86, sY84, sY615; AZFb: sY127, sY134, sY142; AZFc: sY242, sY254, sY255, sY1197, sY1206, sY1125, sY1291 by real-time polymerase chain reaction. Conclusions. The use of molecular genetic and cytogenetic methods is substantiated as a necessary stage in the examination of complicated forms of cryptorchidism, which contributes to more accurate diagnosis and selection of optimal treatment tactics.
| Mualliflar | Султанова Ш.Т, Алимов А.В, Ганиева Ч.Ш, Норпулатова И, Фроянченко Г.А |
|---|---|
| Jurnal | Марказий Осиё эндокринологик журнали |
| Nashriyot | Республика ихтисослаштирилган эндокринология илмий-амалий тиббиёт маркази |
| ISSN | 2181-3426 |
| Nashr sanasi | 2024-07-04 |
| Jild | 4 |
| Son | 1 |
| Til | Ingliz |
| Ilmiy soha | Tibbiyot |
| Indeksga qo‘shilgan | 2026-09-07 |
AZF-локус, микроделецииY хромосомы, гипогонадизм, крипторхизм, гипоспадия, AZF locus, Y chromosome microdeletions, hypogonadism, cryptorchidism, hypospadias, AZF lokus, Y xromosoma mikrodeletsiyasi, gipogonadizm, kriptorxizm, gipospadiya.
| APA | Султанова Ш.Т, Алимов А.В, Ганиева Ч.Ш, Норпулатова И, & Фроянченко Г.А (2024). DELETIONS OF THE AZF LOCUS ON THE Y CHROMOSOME IN CHILDREN AND ADOLESCENTS IN THE DIAGNOSIS OF DISORDERS OF SEXUAL DEVELOPMENT IN BOYS. Марказий Осиё эндокринологик журнали, 4(1). https://www.tadqiqot.uz/index.php/cae/article/view/9744 |
|---|---|
| GOST (OAK) | Султанова Ш.Т va b. DELETIONS OF THE AZF LOCUS ON THE Y CHROMOSOME IN CHILDREN AND ADOLESCENTS IN THE DIAGNOSIS OF DISORDERS OF SEXUAL DEVELOPMENT IN BOYS // Марказий Осиё эндокринологик журнали. – 2024. – T. 4, № 1. |
| MLA | Султанова Ш.Т, Алимов А.В, Ганиева Ч.Ш, Норпулатова И, and Фроянченко Г.А. “DELETIONS OF THE AZF LOCUS ON THE Y CHROMOSOME IN CHILDREN AND ADOLESCENTS IN THE DIAGNOSIS OF DISORDERS OF SEXUAL DEVELOPMENT IN BOYS.” Марказий Осиё эндокринологик журнали, 4(1), 2024. https://www.tadqiqot.uz/index.php/cae/article/view/9744 |
| Chicago | Султанова Ш.Т, Алимов А.В, Ганиева Ч.Ш, Норпулатова И, and Фроянченко Г.А. “DELETIONS OF THE AZF LOCUS ON THE Y CHROMOSOME IN CHILDREN AND ADOLESCENTS IN THE DIAGNOSIS OF DISORDERS OF SEXUAL DEVELOPMENT IN BOYS.” Марказий Осиё эндокринологик журнали, 4(1) (2024). https://www.tadqiqot.uz/index.php/cae/article/view/9744 |
| Harvard | Султанова Ш.Т, Алимов А.В, Ганиева Ч.Ш, Норпулатова И, and Фроянченко Г.А (2024) ‘DELETIONS OF THE AZF LOCUS ON THE Y CHROMOSOME IN CHILDREN AND ADOLESCENTS IN THE DIAGNOSIS OF DISORDERS OF SEXUAL DEVELOPMENT IN BOYS’, Марказий Осиё эндокринологик журнали, 4(1). https://www.tadqiqot.uz/index.php/cae/article/view/9744 |
| BibTeX | @article{article2024,
title = {DELETIONS OF THE AZF LOCUS ON THE Y CHROMOSOME IN CHILDREN AND ADOLESCENTS IN THE DIAGNOSIS OF DISORDERS OF SEXUAL DEVELOPMENT IN BOYS},
author = {Султанова Ш.Т and Алимов А.В and Ганиева Ч.Ш and Норпулатова И and Фроянченко Г.А},
journal = {Марказий Осиё эндокринологик журнали},
year = {2024},
volume = {4},
number = {1},
url = {https://www.tadqiqot.uz/index.php/cae/article/view/9744}
} |
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