Analysis of the relationship between endocrine and microbiota factors and the severity of parkinson’s disease

KHAKIMOVA Sohiba Ziyadulloevna, GAFFAROVA Parvina Abdurafikovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Purpose: To evaluate the clinical significance of hyperthyroidism and gut microbiota alterations in Parkinson’s disease (PD) and to determine their association with disease severity. Methods: The study employed clinical-neurological, laboratory (TSH, TG, T3, T4), microbiota analysis (metagenomic PCR – Streptococcus mutans, Bacteroides, Firmicutes) to determine microbial composition, as well as neuroimaging methods. The Hoehn–Yahr and UPDRS scales, and the MMSE (Mini-Mental State Examination) test were used. Multifactorial statistical analysis methods were applied. Results: The obtained results showed that hyperthyroidism, through thyroid hormones, may accelerate the pathogenesis of PD by influencing dopamine metabolism. Dysbiosis of the gut microbiota, particularly the overgrowth of Streptococcus mutans, increases ImP (imidazole propionate) levels, which enhances mitochondrial stress and α-synuclein aggregation. The elevated Streptococcus mutans population and ImP concentration have a neurotoxic effect on dopaminergic neurons. Therefore, a combined analysis of endocrine and microbiota parameters is essential for assessing PD pathogenesis. Conclusion: In the first (control) group—patients with PD and hypothyroidism—and in the second (comparative) group—patients with PD only—it was observed that hyperthyroidism and microbiota imbalance contributed to increased tremor intensity and progressive cognitive impairment. Assessing motor and cognitive dysfunction dynamics at different stages of the disease, as well as timely correction of endocrine disorders in collaboration with endocrinologists and neurologists, may help maintain disease stability. It is recommended to evaluate microbiota composition and thyroid function in PD patients, and conversely, to assess PD symptoms in patients with hypo- or hyperthyroidism.

Maqola ma’lumotlari
MualliflarKHAKIMOVA Sohiba Ziyadulloevna, GAFFAROVA Parvina Abdurafikovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-01-08
Jild10
Son6
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

Тиреоидный гомеостаз, микробиота, имидазолпропионат (ImP)., Thyroid homeostasis, microbiota, imidazole propionate (ImP)., тиреоид гомеостаз, микробиота, имидазолпропионат (ImP).

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKHAKIMOVA Sohiba Ziyadulloevna, & GAFFAROVA Parvina Abdurafikovna (2026). ANALYSIS OF THE RELATIONSHIP BETWEEN ENDOCRINE AND MICROBIOTA FACTORS AND THE SEVERITY OF PARKINSON’S DISEASE. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6). https://tadqiqot.uz/index.php/biomedicine/article/view/13122
GOST (OAK)KHAKIMOVA Sohiba Ziyadulloevna, GAFFAROVA Parvina Abdurafikovna ANALYSIS OF THE RELATIONSHIP BETWEEN ENDOCRINE AND MICROBIOTA FACTORS AND THE SEVERITY OF PARKINSON’S DISEASE // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 10, № 6.
MLAKHAKIMOVA Sohiba Ziyadulloevna, and GAFFAROVA Parvina Abdurafikovna. “ANALYSIS OF THE RELATIONSHIP BETWEEN ENDOCRINE AND MICROBIOTA FACTORS AND THE SEVERITY OF PARKINSON’S DISEASE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13122
ChicagoKHAKIMOVA Sohiba Ziyadulloevna, and GAFFAROVA Parvina Abdurafikovna. “ANALYSIS OF THE RELATIONSHIP BETWEEN ENDOCRINE AND MICROBIOTA FACTORS AND THE SEVERITY OF PARKINSON’S DISEASE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13122
HarvardKHAKIMOVA Sohiba Ziyadulloevna, and GAFFAROVA Parvina Abdurafikovna (2026) ‘ANALYSIS OF THE RELATIONSHIP BETWEEN ENDOCRINE AND MICROBIOTA FACTORS AND THE SEVERITY OF PARKINSON’S DISEASE’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6). https://tadqiqot.uz/index.php/biomedicine/article/view/13122
BibTeX
@article{khakimovasohibaziyadulloevna2026,
  title = {ANALYSIS OF THE RELATIONSHIP BETWEEN ENDOCRINE AND MICROBIOTA FACTORS AND THE SEVERITY OF PARKINSON’S DISEASE},
  author = {KHAKIMOVA Sohiba Ziyadulloevna and GAFFAROVA Parvina Abdurafikovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {10},
  number = {6},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13122}
}

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