Purpose: To evaluate the clinical significance of hyperthyroidism and gut microbiota alterations in Parkinson’s disease (PD) and to determine their association with disease severity. Methods: The study employed clinical-neurological, laboratory (TSH, TG, T3, T4), microbiota analysis (metagenomic PCR – Streptococcus mutans, Bacteroides, Firmicutes) to determine microbial composition, as well as neuroimaging methods. The Hoehn–Yahr and UPDRS scales, and the MMSE (Mini-Mental State Examination) test were used. Multifactorial statistical analysis methods were applied. Results: The obtained results showed that hyperthyroidism, through thyroid hormones, may accelerate the pathogenesis of PD by influencing dopamine metabolism. Dysbiosis of the gut microbiota, particularly the overgrowth of Streptococcus mutans, increases ImP (imidazole propionate) levels, which enhances mitochondrial stress and α-synuclein aggregation. The elevated Streptococcus mutans population and ImP concentration have a neurotoxic effect on dopaminergic neurons. Therefore, a combined analysis of endocrine and microbiota parameters is essential for assessing PD pathogenesis. Conclusion: In the first (control) group—patients with PD and hypothyroidism—and in the second (comparative) group—patients with PD only—it was observed that hyperthyroidism and microbiota imbalance contributed to increased tremor intensity and progressive cognitive impairment. Assessing motor and cognitive dysfunction dynamics at different stages of the disease, as well as timely correction of endocrine disorders in collaboration with endocrinologists and neurologists, may help maintain disease stability. It is recommended to evaluate microbiota composition and thyroid function in PD patients, and conversely, to assess PD symptoms in patients with hypo- or hyperthyroidism.
| Mualliflar | KHAKIMOVA Sohiba Ziyadulloevna, GAFFAROVA Parvina Abdurafikovna |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2026-01-08 |
| Jild | 10 |
| Son | 6 |
| Til | O‘zbek |
Тиреоидный гомеостаз, микробиота, имидазолпропионат (ImP)., Thyroid homeostasis, microbiota, imidazole propionate (ImP)., тиреоид гомеостаз, микробиота, имидазолпропионат (ImP).
Aim of the research: To evaluate the effectiveness of mirror therapy in the early stage of stroke rehabilitation. Materials and methods: The study involved 9 patients suffering from upper limb motor function impairment…
Objective. To assess the impact of implementing a modular credit system (MCS) on academic performance, digital engagement, motivation, and satisfaction among students and faculty of clinical departments in a medical…
The article discusses modern approaches to diagnostics and targeted therapy in patients with epileptic encephalopathy presenting with continuous spike-wave activity during sleep (DEE-SWAS). Considering the complexity…
Introduction. The modernization of medical education has led to the widespread adoption of the credit-modular system (CMS), which emphasizes practical, competency-based training. However, evidence regarding its effect…
Degenerative spinal canal stenosis (DSCS) is a leading cause of chronic myelopathy and disability, requiring optimization of therapeutic strategies. Objective: To develop personalized treatment algorithms for DSCS based…
The article presents the state of the hemodialysis service in the Samarkand region over the past five years, as well as the number of patients receiving renal replacement therapy for chronic kidney disease, their…
The article analyses contemporary methods of diagnosis, treatment, and rehabilitation of the most severe somatic disorders resulting from perinatal damage to the central nervous system: cerebral palsy in children…
Severe burns during pregnancy are one of the unresolved problems due to the low prevalence of this disease. The outcome of pregnancy always depends on the degree of damage, on the time of provision of qualified…
The article systematizes the theoretical foundations of fractal geometry (fractal dimension, lacunarity, multifractality), describes protocols for obtaining and preprocessing images (histology, dermatoscopy, clinical…
Chronic hepatitis B (HBV) remains one of the leading infectious causes of adverse pregnancy outcomes and perinatal pathology. Viral replication, accompanied by cytolytic syndrome and impaired metabolic functions of the…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar