Personalized algorithms for treating degenerative spinal canal stenosis: from conservative therapy to surgical decompression

Mirjuraev Elbek Mirshavkatovich, Adambaev Zufar Ibragimovich, Mamatxanova Charos Bahodirovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Degenerative spinal canal stenosis (DSCS) is a leading cause of chronic myelopathy and disability, requiring optimization of therapeutic strategies. Objective: To develop personalized treatment algorithms for DSCS based on analysis of patient structure, risk factors, and pelvic organ dysfunction (POD). Materials and Methods. Retrospective analysis of data from 62 DSCS patients (25% of cohort n=250). Comprehensive examination included neurological status (ASIA), urodynamic studies (uroflowmetry, urodynamics, USP scale), and neuroimaging (1.5T MRI, CT myelography). Statistics: IBM SPSS 26.0 (descriptive statistics, Spearman correlation, χ², Mann-Whitney, OR calculation with 95% CI; p<0.05). Results. Predominant findings: thoracic level lesions (Th7–Th12 – 60%), mixed-type POD (58%), and stenosis >50% (82%). Risk factors for severe disability (mRS 4-5): age >50 years (OR=3.2; 95% CI 1.8–5.7), stenosis >70% (OR=4.1; 95% CI 2.3–7.3), urinary retention (OR=5.6; 95% CI 3.1–10.2), and thoracic localization (OR=2.8; 95% CI 1.5–5.1). Conservative therapy was effective (68%) for stenosis <50% and mild POD. Surgical decompression was indicated for stenosis >50%, symptom progression, and conservative treatment failure >3-6 months. Conclusion. A personalized approach considering stenosis severity, lesion level, POD type, and risk factors optimizes DSCS patient management, reducing disability risk and improving quality of life.

Maqola ma’lumotlari
MualliflarMirjuraev Elbek Mirshavkatovich, Adambaev Zufar Ibragimovich, Mamatxanova Charos Bahodirovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-01-08
Jild10
Son6
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

дегенеративный стеноз позвоночного канала; персонализированное лечение; консервативная терапия; хирургическая декомпрессия; нарушение функции тазовых органов; факторы риска; миелопатия; уродинамические нарушения, degenerative spinal canal stenosis; personalized treatment; conservative therapy; surgical decompression; pelvic organ dysfunction; risk factors; myelopathy; urodynamic disorders, umurtqa kanalining degenerativ stenozi; shaxsiylashtirilgan davolash; konservativ terapiya; xirurgik dekompressiya; tazo a'zolar funksiyasining buzilishi; xavf omillari; miyelopatiya; urodinamik buzilishlar

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAMirjuraev Elbek Mirshavkatovich, Adambaev Zufar Ibragimovich, & Mamatxanova Charos Bahodirovna (2026). PERSONALIZED ALGORITHMS FOR TREATING DEGENERATIVE SPINAL CANAL STENOSIS: FROM CONSERVATIVE THERAPY TO SURGICAL DECOMPRESSION. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6). https://tadqiqot.uz/index.php/biomedicine/article/view/13125
GOST (OAK)Mirjuraev Elbek Mirshavkatovich, Adambaev Zufar Ibragimovich, Mamatxanova Charos Bahodirovna PERSONALIZED ALGORITHMS FOR TREATING DEGENERATIVE SPINAL CANAL STENOSIS: FROM CONSERVATIVE THERAPY TO SURGICAL DECOMPRESSION // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 10, № 6.
MLAMirjuraev Elbek Mirshavkatovich, Adambaev Zufar Ibragimovich, and Mamatxanova Charos Bahodirovna. “PERSONALIZED ALGORITHMS FOR TREATING DEGENERATIVE SPINAL CANAL STENOSIS: FROM CONSERVATIVE THERAPY TO SURGICAL DECOMPRESSION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13125
ChicagoMirjuraev Elbek Mirshavkatovich, Adambaev Zufar Ibragimovich, and Mamatxanova Charos Bahodirovna. “PERSONALIZED ALGORITHMS FOR TREATING DEGENERATIVE SPINAL CANAL STENOSIS: FROM CONSERVATIVE THERAPY TO SURGICAL DECOMPRESSION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13125
HarvardMirjuraev Elbek Mirshavkatovich, Adambaev Zufar Ibragimovich, and Mamatxanova Charos Bahodirovna (2026) ‘PERSONALIZED ALGORITHMS FOR TREATING DEGENERATIVE SPINAL CANAL STENOSIS: FROM CONSERVATIVE THERAPY TO SURGICAL DECOMPRESSION’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6). https://tadqiqot.uz/index.php/biomedicine/article/view/13125
BibTeX
@article{mirjuraevelbekmirshavkatovich2026,
  title = {PERSONALIZED ALGORITHMS FOR TREATING DEGENERATIVE SPINAL CANAL STENOSIS: FROM CONSERVATIVE THERAPY TO SURGICAL DECOMPRESSION},
  author = {Mirjuraev Elbek Mirshavkatovich and Adambaev Zufar Ibragimovich and Mamatxanova Charos Bahodirovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {10},
  number = {6},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13125}
}

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