Significance of expression of PD-L1 and P53 proteins in human papillomavirus-associated oropharyngeal squamous cell carcinoma

POLATOVA Djamila Shagayratovna, MADAMINOV Ahmad Yuldashevich, RAXIMOV Nodir Maxammatkulovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2022-yil

Annotatsiya

High-risk human papillomavirus (HPV), causes oropharyngeal squamous cell carcinoma (OSCC), where it is detected in approximately 70% of tumors arising from the lymphoid tissues of the tonsils or the base of the tongue. The study included 76 patients with T1-4N0-3M0 (AJCC, 7th edition) OSCC, who received treatment at the Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology and its Tashkent city branch in the period 2015-2020. An IHC evaluation of the expression of the three molecular markers p16INK4a, PD-L1, and p53 was performed in formalin-fixed and paraffin-embedded samples from 30 selected patients with OSCC. Overexpression of p16INK4a was accompanied by a positive PD-L1 reaction in 46% (6/13) and no positive expression of the p53 mutant type was observed. It is important to note that wild type p53 was identified as an exclusive type in only 1 case (3%) in combination with overexpression of p16INK4a. Establishing the characteristic features of the molecular profile of OSCC can help to better understand its biological characteristics of the tumor, moreover, it plays an important role in the prevention and effective treatment of diseases.

Maqola ma’lumotlari
MualliflarPOLATOVA Djamila Shagayratovna, MADAMINOV Ahmad Yuldashevich, RAXIMOV Nodir Maxammatkulovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2022-09-07
Jild7
Son4
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

Плоскоклеточная карцинома ротоглотки, вирус папилломы человека, иммуногистохимия, молекулярный маркер, экспрессия белка, p16INK4a, PD-L1, p53, Oropharyngeal squamous cell carcinoma, human papillomavirus, immunohistochemistry, molecular marker, protein expression, p16INK4a, PD-L1, p53., Ogiz-halqum yassi hujayrali karsinomasi, odam papilloma virusi, immunogistokimyo, molekulyar marker, oqsil ekspressiyasi, p16INK4a, PD-L1, p53.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAPOLATOVA Djamila Shagayratovna, MADAMINOV Ahmad Yuldashevich, & RAXIMOV Nodir Maxammatkulovich (2022). SIGNIFICANCE OF EXPRESSION OF PD-L1 AND P53 PROTEINS IN HUMAN PAPILLOMAVIRUS-ASSOCIATED OROPHARYNGEAL SQUAMOUS CELL CARCINOMA. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(4). https://tadqiqot.uz/index.php/biomedicine/article/view/5491
GOST (OAK)POLATOVA Djamila Shagayratovna, MADAMINOV Ahmad Yuldashevich, RAXIMOV Nodir Maxammatkulovich SIGNIFICANCE OF EXPRESSION OF PD-L1 AND P53 PROTEINS IN HUMAN PAPILLOMAVIRUS-ASSOCIATED OROPHARYNGEAL SQUAMOUS CELL CARCINOMA // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2022. – T. 7, № 4.
MLAPOLATOVA Djamila Shagayratovna, MADAMINOV Ahmad Yuldashevich, and RAXIMOV Nodir Maxammatkulovich. “SIGNIFICANCE OF EXPRESSION OF PD-L1 AND P53 PROTEINS IN HUMAN PAPILLOMAVIRUS-ASSOCIATED OROPHARYNGEAL SQUAMOUS CELL CARCINOMA.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(4), 2022. https://tadqiqot.uz/index.php/biomedicine/article/view/5491
ChicagoPOLATOVA Djamila Shagayratovna, MADAMINOV Ahmad Yuldashevich, and RAXIMOV Nodir Maxammatkulovich. “SIGNIFICANCE OF EXPRESSION OF PD-L1 AND P53 PROTEINS IN HUMAN PAPILLOMAVIRUS-ASSOCIATED OROPHARYNGEAL SQUAMOUS CELL CARCINOMA.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(4) (2022). https://tadqiqot.uz/index.php/biomedicine/article/view/5491
HarvardPOLATOVA Djamila Shagayratovna, MADAMINOV Ahmad Yuldashevich, and RAXIMOV Nodir Maxammatkulovich (2022) ‘SIGNIFICANCE OF EXPRESSION OF PD-L1 AND P53 PROTEINS IN HUMAN PAPILLOMAVIRUS-ASSOCIATED OROPHARYNGEAL SQUAMOUS CELL CARCINOMA’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(4). https://tadqiqot.uz/index.php/biomedicine/article/view/5491
BibTeX
@article{polatovadjamilashagayratovna2022,
  title = {SIGNIFICANCE OF EXPRESSION OF PD-L1 AND P53 PROTEINS IN HUMAN PAPILLOMAVIRUS-ASSOCIATED OROPHARYNGEAL SQUAMOUS CELL CARCINOMA},
  author = {POLATOVA Djamila Shagayratovna and MADAMINOV Ahmad Yuldashevich and RAXIMOV Nodir Maxammatkulovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2022},
  volume = {7},
  number = {4},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/5491}
}

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