Modern view on ascite in ovarian cancer

ABDURAKHMONOV Jurabek Amrilloevich, RAHIMOV Nodir Makhammatkulovich, SHAKHANOVA Shakhnoza Shavkatovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2022-yil

Annotatsiya

Malignant ascites is often found in ovarian cancer, moreover, about 10% of patients suffer from recurrent ovarian cancer. More than a third of patients with ovarian cancer have ascites while diagnosed, and almost all has ascites when it relapses. The presence of ascites correlates with the peritoneal spread of ovarian cancer and is associated with a poor prognosis of the disease. Malignant ascites acts as a reservoir of a complex mixture of soluble factors and cellular components that provide a tumor-stimulating microenvironment for tumor cells. Tumor cells in OV associated malignant ascites contribute to the recurrence of the disease, and the mortality of patients is mainly associated with dissemination and metastasis with concomitant effusions in the abdominal cavity. Malignant cells derived from ascites are a major source of morbidity and mortality for patients with ovarian cancer. Subpopulations of these tumor cells have increased resistance to therapy and the ability to distant metastasis and relapse. The anti-angiogenic targeted agent bevacizumab and pazopanib also showed good effects in the symptomatic treatment of malignant ascites of the ovarian cancer, significantly prolonging the time until the next paracentesis. An endothelial vascular growth factor (VEGF) inhibitor is a fusion protein that inhibits the binding of a VEGF receptor. Thus, we conclude that further large-scale studies are needed to find out whether a reduction in ascites by these targeted drugs leads to prolonging in the survival time associated with the tumor or not.

Maqola ma’lumotlari
MualliflarABDURAKHMONOV Jurabek Amrilloevich, RAHIMOV Nodir Makhammatkulovich, SHAKHANOVA Shakhnoza Shavkatovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2022-09-05
Jild7
Son4
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

рак яичника, асцит, таргетная терапия, бевизумаб, пазопаниб, ovarian cancer, ascites, targeted therapy, bevizumab, pazopanib, тухумдонлар саратони, асцит, таргет терапия, бевизумаб, пазопаниб

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAABDURAKHMONOV Jurabek Amrilloevich, RAHIMOV Nodir Makhammatkulovich, & SHAKHANOVA Shakhnoza Shavkatovna (2022). MODERN VIEW ON ASCITE IN OVARIAN CANCER. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(4). https://tadqiqot.uz/index.php/biomedicine/article/view/5489
GOST (OAK)ABDURAKHMONOV Jurabek Amrilloevich, RAHIMOV Nodir Makhammatkulovich, SHAKHANOVA Shakhnoza Shavkatovna MODERN VIEW ON ASCITE IN OVARIAN CANCER // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2022. – T. 7, № 4.
MLAABDURAKHMONOV Jurabek Amrilloevich, RAHIMOV Nodir Makhammatkulovich, and SHAKHANOVA Shakhnoza Shavkatovna. “MODERN VIEW ON ASCITE IN OVARIAN CANCER.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(4), 2022. https://tadqiqot.uz/index.php/biomedicine/article/view/5489
ChicagoABDURAKHMONOV Jurabek Amrilloevich, RAHIMOV Nodir Makhammatkulovich, and SHAKHANOVA Shakhnoza Shavkatovna. “MODERN VIEW ON ASCITE IN OVARIAN CANCER.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(4) (2022). https://tadqiqot.uz/index.php/biomedicine/article/view/5489
HarvardABDURAKHMONOV Jurabek Amrilloevich, RAHIMOV Nodir Makhammatkulovich, and SHAKHANOVA Shakhnoza Shavkatovna (2022) ‘MODERN VIEW ON ASCITE IN OVARIAN CANCER’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(4). https://tadqiqot.uz/index.php/biomedicine/article/view/5489
BibTeX
@article{abdurakhmonovjurabekamrilloevich2022,
  title = {MODERN VIEW ON ASCITE IN OVARIAN CANCER},
  author = {ABDURAKHMONOV Jurabek Amrilloevich and RAHIMOV Nodir Makhammatkulovich and SHAKHANOVA Shakhnoza Shavkatovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2022},
  volume = {7},
  number = {4},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/5489}
}

Boshqa maqola uchun iqtibos tayyorlash

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali jurnalidan boshqa maqolalar

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar · 2022-yil arxivi

ABDURAKHMONOV Jurabek Amrilloevich — boshqa maqolalari

Tibbiyot sohasidagi boshqa maqolalar

Tibbiyot sohasidagi OAK jurnallari