The preventive effect of calcium channel blockers at adjuvant-induced arthritis on the course of chronic arthritis, hematological blood parameters, as well as on the content of cytokines and C-reactive protein was studied in sexually mature male rats weighing 140-160 g. It has been established that calcium channel antagonists have an inhibitory effect on the development of adjuvant-induced arthritis, especially diltiazem and cinnarizine, which have an almost identical effect to diclofenac sodium. A more pronounced correction of violations of hematological parameters was observed in animals receiving prophylactic diltiazem. One of the mechanisms of the antiflagogenic action of calcium channel blockers is a decrease in the level of pro-inflammatory and an increase in anti-inflammatory interleukins.
| Mualliflar | KHAKIMOV Ziyaviddin Zaynutdinovich, RAKHMANOV Alisher Khudaiberdievich, BEKOVA Nodira Bahаdirovna |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2022-09-04 |
| Jild | 7 |
| Son | 4 |
| Til | Rus |
адъювант индуцированный артрит, антагонисты кальциевых каналов, гематология, цитокины, adjuvant-induced arthritis, calcium channel antagonists, hematology, cytokines., адъювант билан чақирилган артрит, кальций канали антагонистлари, гематология, цитокинлар
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