The state of pro- and antioxidant systems in newborns born to mothers with endotoxicosis

Shavazi, Nargiz, Mamarizaev, Ibroxim, Шавази, Наргиз, Мамаризаев, Иброхим, Shavazi, Nargiz, Mamarizaev, Ibroxim

Халқаро илмий педиатрия журнали · 2025-yil

Annotatsiya

Actuality. Maternal endotoxicosis is a pathological condition characterized by the accumulation of toxic metabolites in the body, which significantly affects the condition of the fetus and newborn. One of the key mechanisms of tissue damage in endotoxicosis is the activation of lipid peroxidation processes (LPO) and disruption of the antioxidant system (AOS), leading to oxidative stress. Newborns born to mothers with endotoxicosis exhibit elevated levels of LPO products such as malondialdehyde (MDA) and diene conjugates (DC), as well as reduced activity of antioxidant defense enzymes like superoxide dismutase (SOD), catalase, and glutathione peroxidase. The aim of this study was to investigate the state of pro- and antioxidant systems in newborns born to mothers with endotoxicosis. Methods. A total of 83 newborns were examined and divided into two groups: a control group consisting of 41 healthy newborns born to healthy mothers and a main group consisting of 42 newborns born to mothers with endotoxicosis. Biochemical methods were used to assess SOD and catalase activity as well as LPO product levels. The results showed that MDA and DC levels in the main group were significantly higher than in the control group (p<0.05). At the same time, SOD activity decreased by 45–64%, indicating depletion of antioxidant defense resources. However, catalase activity increased by 1.4–1.7 times, suggesting a compensatory mechanism for neutralizing reactive oxygen species. The findings indicate that maternal endotoxicosis disrupts the balance between pro- and antioxidant systems in newborns, leading to oxidative stress and impairing their adaptive capabilities. Further research into these processes and the development of effective therapeutic approaches are necessary.

Maqola ma’lumotlari
MualliflarShavazi, Nargiz, Mamarizaev, Ibroxim, Шавази, Наргиз, Мамаризаев, Иброхим, Shavazi, Nargiz, Mamarizaev, Ibroxim
JurnalХалқаро илмий педиатрия журнали
NashriyotАндижон давлат тиббиёт институти; In Science МЧЖ
ISSN2181-2926, 2181-2926
Nashr sanasi2025-04-18
Jild4
Son2
Betlar887-890
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-2926-2025-4-2-887-890
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-2926-2025-4-2-887-890 · Maqolaning asl sahifasi

Kalit so‘zlar

эндотоксикоз, оксидативный стресс, новорожденные, малоновый диальдегид, endotoxicosis, newborns, intoxication, catalase, diene conjugates, malondialdehyde, endotoksikoz, yangi tug‘ilgan chaqaloqlar, intoksikatsiya, katalaza, dien kon’yugata, malon dialdegid

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAShavazi, Nargiz, Mamarizaev, Ibroxim, Шавази, Наргиз, Мамаризаев, Иброхим, Shavazi, Nargiz, & Mamarizaev, Ibroxim (2025). THE STATE OF PRO- AND ANTIOXIDANT SYSTEMS IN NEWBORNS BORN TO MOTHERS WITH ENDOTOXICOSIS. Халқаро илмий педиатрия журнали, 4(2), 887-890. https://doi.org/10.56121/2181-2926-2025-4-2-887-890
GOST (OAK)Shavazi, Nargiz va b. THE STATE OF PRO- AND ANTIOXIDANT SYSTEMS IN NEWBORNS BORN TO MOTHERS WITH ENDOTOXICOSIS // Халқаро илмий педиатрия журнали. – 2025. – T. 4, № 2. – P. 887-890. – DOI: 10.56121/2181-2926-2025-4-2-887-890.
MLAShavazi, Nargiz, Mamarizaev, Ibroxim, Шавази, Наргиз, Мамаризаев, Иброхим, Shavazi, Nargiz, and Mamarizaev, Ibroxim. “THE STATE OF PRO- AND ANTIOXIDANT SYSTEMS IN NEWBORNS BORN TO MOTHERS WITH ENDOTOXICOSIS.” Халқаро илмий педиатрия журнали, 4(2), 887-890, 2025. https://doi.org/10.56121/2181-2926-2025-4-2-887-890
ChicagoShavazi, Nargiz, Mamarizaev, Ibroxim, Шавази, Наргиз, Мамаризаев, Иброхим, Shavazi, Nargiz, and Mamarizaev, Ibroxim. “THE STATE OF PRO- AND ANTIOXIDANT SYSTEMS IN NEWBORNS BORN TO MOTHERS WITH ENDOTOXICOSIS.” Халқаро илмий педиатрия журнали, 4(2), 887-890 (2025). https://doi.org/10.56121/2181-2926-2025-4-2-887-890
HarvardShavazi, Nargiz, Mamarizaev, Ibroxim, Шавази, Наргиз, Мамаризаев, Иброхим, Shavazi, Nargiz, and Mamarizaev, Ibroxim (2025) ‘THE STATE OF PRO- AND ANTIOXIDANT SYSTEMS IN NEWBORNS BORN TO MOTHERS WITH ENDOTOXICOSIS’, Халқаро илмий педиатрия журнали, 4(2), 887-890. https://doi.org/10.56121/2181-2926-2025-4-2-887-890
BibTeX
@article{shavazinargiz2025,
  title = {THE STATE OF PRO- AND ANTIOXIDANT SYSTEMS IN NEWBORNS BORN TO MOTHERS WITH ENDOTOXICOSIS},
  author = {Shavazi, Nargiz and Mamarizaev, Ibroxim and Шавази, Наргиз and Мамаризаев, Иброхим and Shavazi, Nargiz and Mamarizaev, Ibroxim},
  journal = {Халқаро илмий педиатрия журнали},
  year = {2025},
  volume = {4},
  number = {2},
  pages = {887-890},
  doi = {10.56121/2181-2926-2025-4-2-887-890},
  url = {https://doi.org/10.56121/2181-2926-2025-4-2-887-890}
}

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