Morphological changes of the heart wall when mexidol is used in experimental hypothyroidism

Mirzamukhamedov, Odiljon, Мирзамухамедов, Одилжон, Mirzamuxamedov, Odiljon

Халқаро илмий педиатрия журнали · 2025-yil

Annotatsiya

Relevance. There are systemic consequences of hypothyroidism on the heart among other organs. It could cause modifications to heart rate, contractility, and relaxation, among other aspects of cardiac function. The structural alterations of the heart, such as the hypertrophy (enlargement) of the heart muscle cells, may be influenced by hypothyroidism. Purpose of the study identification of morphological and functional features of postnatal development and formation of the myocardium of offspring obtained under conditions of experimental hypothyroidism in the mother. Тhe object of the study was female white outbred rats and their offspring on 3,7,14,21 and 30 days after birth. Experimental hypothyroidism in female rats was modeled by introducing mercazolil before pregnancy. The myocardium of the heart was studied using morphological, morphometric and electron microscopic research methods. Thus, analysis of the results of the study showed that the offspring of rats born to mothers with experimental hypothyroidism, starting from the 14th day after birth, develop vascular disorders in the myocardium, degenerative changes in the form of intracellular myocytolysis, disbandment of myofibrils, interstitial edema, and fragmentation of muscle fibers. Conclusions: experimental hypothyroidism reproduced in female rats leads to a pronounced disruption of the morphofunctional formation of the offspring myocardium and is a risk factor for the development of cardiovascular diseases.

Maqola ma’lumotlari
MualliflarMirzamukhamedov, Odiljon, Мирзамухамедов, Одилжон, Mirzamuxamedov, Odiljon
JurnalХалқаро илмий педиатрия журнали
NashriyotАндижон давлат тиббиёт институти; In Science МЧЖ
ISSN2181-2926, 2181-2926
Nashr sanasi2025-04-18
Jild4
Son2
Betlar907-916
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-2926-2025-4-2-907-916
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-2926-2025-4-2-907-916 · Maqolaning asl sahifasi

Kalit so‘zlar

Миокард, сердечная мышца, гипотиреоз, экспериментальная модель, кардиомиоциты, иммуногистохимия, мексидол, Myocardium, heart muscle, hypothyroidism, experimental model, cardiomyocytes, immunohistochemistry, mexidol, Miokard, yurak mushagi, gipotireoz, eksperimental model, kardiomiotsitlar, immunogistokimyo, meksidol

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAMirzamukhamedov, Odiljon, Мирзамухамедов, Одилжон, & Mirzamuxamedov, Odiljon (2025). MORPHOLOGICAL CHANGES OF THE HEART WALL WHEN MEXIDOL IS USED IN EXPERIMENTAL HYPOTHYROIDISM. Халқаро илмий педиатрия журнали, 4(2), 907-916. https://doi.org/10.56121/2181-2926-2025-4-2-907-916
GOST (OAK)Mirzamukhamedov, Odiljon, Мирзамухамедов, Одилжон, Mirzamuxamedov, Odiljon MORPHOLOGICAL CHANGES OF THE HEART WALL WHEN MEXIDOL IS USED IN EXPERIMENTAL HYPOTHYROIDISM // Халқаро илмий педиатрия журнали. – 2025. – T. 4, № 2. – P. 907-916. – DOI: 10.56121/2181-2926-2025-4-2-907-916.
MLAMirzamukhamedov, Odiljon, Мирзамухамедов, Одилжон, and Mirzamuxamedov, Odiljon. “MORPHOLOGICAL CHANGES OF THE HEART WALL WHEN MEXIDOL IS USED IN EXPERIMENTAL HYPOTHYROIDISM.” Халқаро илмий педиатрия журнали, 4(2), 907-916, 2025. https://doi.org/10.56121/2181-2926-2025-4-2-907-916
ChicagoMirzamukhamedov, Odiljon, Мирзамухамедов, Одилжон, and Mirzamuxamedov, Odiljon. “MORPHOLOGICAL CHANGES OF THE HEART WALL WHEN MEXIDOL IS USED IN EXPERIMENTAL HYPOTHYROIDISM.” Халқаро илмий педиатрия журнали, 4(2), 907-916 (2025). https://doi.org/10.56121/2181-2926-2025-4-2-907-916
HarvardMirzamukhamedov, Odiljon, Мирзамухамедов, Одилжон, and Mirzamuxamedov, Odiljon (2025) ‘MORPHOLOGICAL CHANGES OF THE HEART WALL WHEN MEXIDOL IS USED IN EXPERIMENTAL HYPOTHYROIDISM’, Халқаро илмий педиатрия журнали, 4(2), 907-916. https://doi.org/10.56121/2181-2926-2025-4-2-907-916
BibTeX
@article{mirzamukhamedovodiljon2025,
  title = {MORPHOLOGICAL CHANGES OF THE HEART WALL WHEN MEXIDOL IS USED IN EXPERIMENTAL HYPOTHYROIDISM},
  author = {Mirzamukhamedov, Odiljon and Мирзамухамедов, Одилжон and Mirzamuxamedov, Odiljon},
  journal = {Халқаро илмий педиатрия журнали},
  year = {2025},
  volume = {4},
  number = {2},
  pages = {907-916},
  doi = {10.56121/2181-2926-2025-4-2-907-916},
  url = {https://doi.org/10.56121/2181-2926-2025-4-2-907-916}
}

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