The work is devoted to the development of techniques for determining the radiochemical purity (the content of the connected target radionuclide) and chemical purity (the content of nonradioactive impurity elements Cu, Fe, Pb, Zn, Yb, etc. of the radiopharmaceuticals 177LuPSMA-617, produced in the State Enterprise "Radiopreparat". At the development of the techniques, the methods of paper chromatography and atomic emission spectrometry with inductively coupled plasma (ICP-AES) are used. The paper chromatography method made it possible to determine the radiochemical purity of the preparation up to 99.0%, and ICP-AES determined the limited impurities of Cu, Fe, Pb, Zn, Yb up to 0.35 µg/GBq. The characteristics of the developed methods fully meet the regulatory requirements established for radiopharmaceuticals.
| Mualliflar | Хажиев, Л.О., Садиков, И.И., Абдукаюмов, А.М., Мадниязов, Ш.А. |
|---|---|
| Jurnal | O‘zbekiston fizika jurnali |
| Nashriyot | Ўзбекистон Республикаси Фанлар академияси |
| ISSN | 1025-8817, 2181-077X |
| Nashr sanasi | 2026-10-22 |
| Jild | 28 |
| Son | 3 |
| Til | Ingliz |
| Ilmiy soha | Fizika-matematika |
| DOI | 10.52304/.v28i3.668 |
| Indeksga qo‘shilgan | 2026-10-23 |
DOI: 10.52304/.v28i3.668 · Maqolaning asl sahifasi
радиофармацевтические препараты, ПСМА-617, рак предстательной железы, радиохимическая чистота, бумажная хроматография, атомно-эмиссионная спектрометрия, radiopharmaceuticals, PSMA-617, prostate cancer, radiochemical purity, paper chromatography, atomic emission spectrometry
| APA | Хажиев, Л.О., Садиков, И.И., Абдукаюмов, А.М., & Мадниязов, Ш.А. (2026). Determination of the radiochemical and chemical purity of the radiopharmaceutical drug prostate-specific membrane antigen labeled with lutetium-177 (177Lu-PSMA-617). O‘zbekiston fizika jurnali, 28(3). https://doi.org/10.52304/.v28i3.668 |
|---|---|
| GOST (OAK) | Хажиев, Л.О. va b. Determination of the radiochemical and chemical purity of the radiopharmaceutical drug prostate-specific membrane antigen labeled with lutetium-177 (177Lu-PSMA-617) // O‘zbekiston fizika jurnali. – 2026. – T. 28, № 3. – DOI: 10.52304/.v28i3.668. |
| MLA | Хажиев, Л.О., Садиков, И.И., Абдукаюмов, А.М., and Мадниязов, Ш.А. “Determination of the radiochemical and chemical purity of the radiopharmaceutical drug prostate-specific membrane antigen labeled with lutetium-177 (177Lu-PSMA-617).” O‘zbekiston fizika jurnali, 28(3), 2026. https://doi.org/10.52304/.v28i3.668 |
| Chicago | Хажиев, Л.О., Садиков, И.И., Абдукаюмов, А.М., and Мадниязов, Ш.А. “Determination of the radiochemical and chemical purity of the radiopharmaceutical drug prostate-specific membrane antigen labeled with lutetium-177 (177Lu-PSMA-617).” O‘zbekiston fizika jurnali, 28(3) (2026). https://doi.org/10.52304/.v28i3.668 |
| Harvard | Хажиев, Л.О., Садиков, И.И., Абдукаюмов, А.М., and Мадниязов, Ш.А (2026) ‘Determination of the radiochemical and chemical purity of the radiopharmaceutical drug prostate-specific membrane antigen labeled with lutetium-177 (177Lu-PSMA-617)’, O‘zbekiston fizika jurnali, 28(3). https://doi.org/10.52304/.v28i3.668 |
| BibTeX | @article{article2026,
title = {Determination of the radiochemical and chemical purity of the radiopharmaceutical drug prostate-specific membrane antigen labeled with lutetium-177 (177Lu-PSMA-617)},
author = {Хажиев, Л.О. and Садиков, И.И. and Абдукаюмов, А.М. and Мадниязов, Ш.А.},
journal = {O‘zbekiston fizika jurnali},
year = {2026},
volume = {28},
number = {3},
doi = {10.52304/.v28i3.668},
url = {https://doi.org/10.52304/.v28i3.668}
} |
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