Iron deficiency anemia (IDA) represents a significant global health issue affecting a considerable proportion of women of reproductive age, particularly more than 40% of pregnant women. Iron is essential not only for hematopoiesis but also plays a critical role in cellular respiration, functioning of enzyme systems, angiogenesis, and myelination of fetal neural tissue. The requirement for iron substantially increases during pregnancy, thereby heightening the risk of iron deficiency states, which may lead to placental insufficiency and complications during pregnancy. Particularly important is the investigation of pathomorphological changes in the mother-placenta-fetus system among women with menstruation-associated IDA due to chronic heavy menstrual bleeding (HMB). In our study, marked pathological alterations in the umbilical cord vessel structures were identified, characterized by ischemia, sclerosis, and disruptions in endothelial architecture, confirmed by light and electron microscopy. The endothelial cells demonstrated degenerative changes, loss of normal surface relief, and destructive processes, indicating significant metabolic and vascular perfusion disturbances. These morphological alterations significantly affect the functionality of the fetoplacental complex, highlighting an increased risk of fetoplacental insufficiency, intrauterine growth restriction, and other perinatal complications. The identified changes carry crucial prognostic implications and underscore the importance of timely diagnosis and correction of iron deficiency states in women of reproductive age.
| Mualliflar | Насирова Зебинисо Азизовна |
|---|---|
| Jurnal | Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) |
| Nashr sanasi | 2026-05-25 |
| Jild | 6 |
| Son | 3 |
| Til | Rus |
анемия, железодефицитная анемия, беременность, обильные менструации, аномальные маточные кровотечения, FIGO, плацентарная недостаточность, дефицит железа, здоровье матери и плода, anemia, iron deficiency anemia, pregnancy, heavy menstruation, abnormal uterine bleeding, FIGO, placental insufficiency, iron deficiency, maternal and fetal health, anemiya, temir tanqisligi anemiyasi, homiladorlik, ko‘p miqdordagi hayz ko‘rish, anormal bachadon qon ketishlari, FIGO, plasentar yetishmovchilik, temir tanqisligi, ona va homila salomatligi
Introduction. Iron deficiency anemia (IDA) occupies an important place among pathologies affecting women’s reproductive health, especially during pregnancy. Disturbances in the balance of macro- and microelements in the…
Recurrent genital herpes, caused by herpes simplex virus types 1 and 2, is a serious medical and social problem characterized by a chronic course with periodic exacerbations. The severity of the clinical course of…
Surgical treatment of pelvic organ prolapse (POP) is considered a functional approach aimed at restoring pelvic anatomy and eliminating symptoms that significantly affect patients' quality of life. Over the past…
Endometriosis affects 176 million women of reproductive age worldwide. Ovarian endometriomas account for 30-40% of patients with endometriosis. We studied 42 women with a mean age of 34.07±4.88 years with ovarian…
The menopausal period is a physiological transition period in a woman's life, which occupies the period of time between the reproductive phase and old age.During this period, against the background of age-related…
The study is devoted to the study of the course of pregnancy with varicose veins and ways to prevent complications. On the basis of the multidisciplinary clinic of the Samarkand State Medical University and the…
The article evaluates conservative myomectomy as a fibroid treatment while examining its treatment success and benefits with associated surgical complications. Uterine fibroids known as leiomyomas manifest as benign…