Recurrent chronic suppurative otitis media is characterized by a persistent inflammatory process involving the structures of the middle ear, with repeated exacerbations and structural alterations of the mucosa, granulation tissue, and bony components. Impaired tissue repair, persistent inflammatory cell infiltration, fibrosis, microcirculatory abnormalities, and disturbances of the local immune response may contribute to recurrence and persistence of the pathological process. The aim of the study is to evaluate the morphological and immunohistochemical characteristics of middle ear tissues in recurrent chronic suppurative otitis media and to determine their role in maintaining chronic inflammation. Morphological assessment of surgical specimens includes evaluation of inflammatory cell infiltration, epithelial alterations, granulation tissue formation, fibrosis, and destructive tissue changes. Immunohistochemical examination provides additional information on cellular proliferation, inflammatory activity, angiogenesis, apoptosis, and connective tissue remodeling. Identification of relationships between structural tissue damage and local immune responses contributes to a more comprehensive understanding of the pathogenetic mechanisms responsible for recurrent disease. Combined morphological and immunohistochemical assessment may be useful for determining the activity of the pathological process, assessing the risk of recurrent inflammation, and improving approaches to surgical treatment and postoperative follow-up of patients with chronic suppurative otitis media.
| Mualliflar | J.A. Xusanov |
|---|---|
| Jurnal | Zamonaviy tibbiyot jurnali / Journal of modern medicine |
| Nashriyot | Андижон давлат тиббиёт институти |
| ISSN | 2992-8958 |
| Nashr sanasi | 2026-08-12 |
| Jild | 14 |
| Son | 3 |
| Betlar | 729-735 |
| Til | Ingliz |
| Ilmiy soha | Tibbiyot |
| DOI | 10.67519/nshr.ztj.2026.03.104 |
| Indeksga qo‘shilgan | 2026-09-02 |
DOI: 10.67519/nshr.ztj.2026.03.104 · Maqolaning asl sahifasi · PDF
| APA | J.A. Xusanov (2026). MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES IN TISSUES IN RECURRENT CHRONIC SUPPURATIVE OTITIS MEDIA. Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 729-735. https://doi.org/10.67519/nshr.ztj.2026.03.104 |
|---|---|
| GOST (OAK) | J.A. Xusanov MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES IN TISSUES IN RECURRENT CHRONIC SUPPURATIVE OTITIS MEDIA // Zamonaviy tibbiyot jurnali / Journal of modern medicine. – 2026. – T. 14, № 3. – P. 729-735. – DOI: 10.67519/nshr.ztj.2026.03.104. |
| MLA | J.A. Xusanov. “MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES IN TISSUES IN RECURRENT CHRONIC SUPPURATIVE OTITIS MEDIA.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 729-735, 2026. https://doi.org/10.67519/nshr.ztj.2026.03.104 |
| Chicago | J.A. Xusanov. “MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES IN TISSUES IN RECURRENT CHRONIC SUPPURATIVE OTITIS MEDIA.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 729-735 (2026). https://doi.org/10.67519/nshr.ztj.2026.03.104 |
| Harvard | J.A. Xusanov (2026) ‘MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES IN TISSUES IN RECURRENT CHRONIC SUPPURATIVE OTITIS MEDIA’, Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 729-735. https://doi.org/10.67519/nshr.ztj.2026.03.104 |
| BibTeX | @article{jaxusanov2026,
title = {MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES IN TISSUES IN RECURRENT CHRONIC SUPPURATIVE OTITIS MEDIA},
author = {J.A. Xusanov},
journal = {Zamonaviy tibbiyot jurnali / Journal of modern medicine},
year = {2026},
volume = {14},
number = {3},
pages = {729-735},
doi = {10.67519/nshr.ztj.2026.03.104},
url = {https://doi.org/10.67519/nshr.ztj.2026.03.104}
} |
Boshqa maqola uchun iqtibos tayyorlash
Pelvic organ prolapse is a common pelvic floor problem for women. Pelvic organ prolapse hurts women’s quality of life, hurts women’s productivity, and hurts women’s reproductive health. In recent years researchers have…
Prediabetes is a potentially reversible disorder of carbohydrate metabolism characterized by elevated blood glucose levels, insulin resistance, and a high risk of progression to type 2 diabetes mellitus. This article…
The article analyzes the clinical and pharmacological characteristics of medication use during pregnancy and breastfeeding. Physiological changes occurring in the maternal organism significantly affect drug absorption…
Clinical and epidemiological studies show that bronchial obstruction associated with bronchial asthma and chronic obstructive pulmonary disease is widespread among the population of different ages and that its frequency…
Background. Biochemical biomarkers are increasingly important for assessing functional recovery and predicting rehabilitation outcomes after ischemic stroke. Objective. To determine the clinical significance of LDH…
Objective. To identify the clinical, anamnestic and reproductive characteristics of infertile women with autoimmune thyroiditis (AIT). Materials and methods. This comparative observational study included 190 infertile…
Clinical and epidemiological studies show that bronchial obstruction associated with bronchial asthma and chronic obstructive pulmonary disease is widespread among the population of different ages and that its frequency…
Bariatric surgery provides a substantial and sustained reduction in body weight and contributes to the improvement of obesity-related metabolic disorders. However, anatomical and functional changes in the…
The aim of the study was to investigate the effects of experimental chronic carbon monoxide intoxication on the morphological and morphometric characteristics of the frontal cortex of the cerebral hemispheres in 3, 9…
In recent years, among the genes associated with success in sports and adaptation to physical exertion, NOS3 (endothelial nitric oxide synthase gene) has garnered particular attention. Polymorphisms of the NOS3 gene…
Zamonaviy tibbiyot jurnali / Journal of modern medicine — barcha maqolalar · 2026-yil arxivi
Настоящее исследование посвящено разработке алгоритма раннего выявления сенсоневральной тугоухости у детей с использованием методов полимеразной цепной реакции (ПЦР). Обследовано 235 детей с нарушениями слуха, из…
В статье представлены клинические аспекты и диагностические проблемы выявления сенсоневральной тугоухости у новорождённых с перинатальной патологией. Обследовано 115 новорождённых, из которых 35 перенесли асфиксию, а у…
Сенсоневральная тугоухость (СНТ) у детей остаётся одной из наиболее актуальных проблем современной оториноларингологии и медицинской генетики. Ранняя диагностика нарушений слуха играет ключевую роль в предупреждении…
Сенсоневральная тугоухость у новорождённых является одной из ведущих причин нарушения слухоречевого развития и ранней инвалидизации. Наиболее уязвимыми считаются дети, перенёсшие перинатальные осложнения, такие как…
Mazkur eksperimental tadqiqotda yuqori yog‘li ratsion va seftriaksonning lipid hamda uglevod almashinuviga alohida va birgalikdagi ta’siri 160 ta oq zotsiz erkak kalamushda o‘rganildi. Tajriba hayvonlari to‘rtta guruhga…
Мазкур тадқиқотда Тошкет вилоятидаги Ўрта Чирчиқ тумани 25-сонли, Бўка тумани 3-сонли ва 9-сонли давлат мактабгача таълим ташкилотларида 2025 йил ёз мавсумидаги таомномаларнинг озиқ-овқат маҳсулотлари билан…