Synthesis of 2-METHYL-PYRAZOLO [3,4-d]PYRIMIDINONES

F. Ruzieva, D. Turgunov, Kh. Bozorov

Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi · 2026-yil

Annotatsiya

Current research in the field of medicinal and organic chemistry is focused on the study of heterocyclic synthons, which are the basis of complex organic molecules with biological activity. In this study, tri-, tetra-, and pentamethylenepyrazolo[3,4-d]pyrimidinones were synthesized from methyl 3-amino-1-methyl-1H-pyrazole-4-carboxylate in one-step cyclocondensation reactions, resulting in the synthesis of three new compounds. The results of molecular docking of the obtained compounds showed that they have a strong inhibitory potential against target proteins associated with neurodegenerative diseases. These results may serve as an important scientific basis for the development of new drug candidates for the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's in the future.

Maqola ma’lumotlari
MualliflarF. Ruzieva, D. Turgunov, Kh. Bozorov
JurnalSamarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi
NashriyotСамарқанд давлат университети
ISSN2091-5446, 2181-1296
Nashr sanasi2026-01-01
Jild1
Son1
Betlar49-53
TilIngliz
Ilmiy sohaKimyo
DOI10.59251/2181-3973.2025.v1.138.1.3753
Indeksga qo‘shilgan2026-09-02

DOI: 10.59251/2181-3973.2025.v1.138.1.3753 · Maqolaning asl sahifasi

Ilmiy soha

Kimyo

Iqtibos keltirish

APAF. Ruzieva, D. Turgunov, & Kh. Bozorov (2026). SYNTHESIS OF 2-METHYL-PYRAZOLO [3,4-d]PYRIMIDINONES. Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi, 1(1), 49-53. https://doi.org/10.59251/2181-3973.2025.v1.138.1.3753
GOST (OAK)F. Ruzieva, D. Turgunov, Kh. Bozorov SYNTHESIS OF 2-METHYL-PYRAZOLO [3,4-d]PYRIMIDINONES // Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi. – 2026. – T. 1, № 1. – P. 49-53. – DOI: 10.59251/2181-3973.2025.v1.138.1.3753.
MLAF. Ruzieva, D. Turgunov, and Kh. Bozorov. “SYNTHESIS OF 2-METHYL-PYRAZOLO [3,4-d]PYRIMIDINONES.” Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi, 1(1), 49-53, 2026. https://doi.org/10.59251/2181-3973.2025.v1.138.1.3753
ChicagoF. Ruzieva, D. Turgunov, and Kh. Bozorov. “SYNTHESIS OF 2-METHYL-PYRAZOLO [3,4-d]PYRIMIDINONES.” Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi, 1(1), 49-53 (2026). https://doi.org/10.59251/2181-3973.2025.v1.138.1.3753
HarvardF. Ruzieva, D. Turgunov, and Kh. Bozorov (2026) ‘SYNTHESIS OF 2-METHYL-PYRAZOLO [3,4-d]PYRIMIDINONES’, Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi, 1(1), 49-53. https://doi.org/10.59251/2181-3973.2025.v1.138.1.3753
BibTeX
@article{fruzieva2026,
  title = {SYNTHESIS OF 2-METHYL-PYRAZOLO [3,4-d]PYRIMIDINONES},
  author = {F. Ruzieva and D. Turgunov and Kh. Bozorov},
  journal = {Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi},
  year = {2026},
  volume = {1},
  number = {1},
  pages = {49-53},
  doi = {10.59251/2181-3973.2025.v1.138.1.3753},
  url = {https://doi.org/10.59251/2181-3973.2025.v1.138.1.3753}
}

Boshqa maqola uchun iqtibos tayyorlash

Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi jurnalidan boshqa maqolalar

Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi — barcha maqolalar · 2026-yil arxivi

Kimyo sohasidagi boshqa maqolalar

Kimyo sohasidagi OAK jurnallari