The role of ferroptosis in the pathogenesis of symptomatic epilepsy: a clinical and neuroimaging study

Азизова Раъно Баходировна, Аббосхонов Асрорхон Аббосхон угли

Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2026-yil

Annotatsiya

Objective: To investigate the role of iron metabolism disorders and ferroptosis mechanisms in the pathogenesis of symptomatic epilepsy. Materials and methods: A prospective controlled cohort study was conducted involving 80 patients with symptomatic epilepsy and 30 healthy individuals. Clinical and neurological manifestations, cognitive functions (MMSE, TMT), iron metabolism parameters, ferroptosis markers (GPX4, ACSL4, MDA), MRI and EEG data were evaluated. Results: Patients with symptomatic epilepsy showed significant cognitive function decline (MMSE: 24.3±2.5 vs 28.7±1.3 points, p<0.01), iron metabolism disorders with elevated ferritin levels (320±25 vs 210±20 ng/ml, p<0.01), decreased GPX4 expression by 1.8-fold (p<0.01), increased ACSL4 by 2.3-fold (p<0.01), and elevated MDA to 6.1±0.5 nmol/mg protein (p<0.001). SWI-MRI revealed iron accumulation in the basal ganglia, hippocampus, and thalamus in 50% of patients. Conclusion: Iron metabolism disorders and ferroptosis activation play a key role in the pathogenesis of symptomatic epilepsy, opening prospects for developing pathogenetically targeted therapy.

Maqola ma’lumotlari
MualliflarАзизова Раъно Баходировна, Аббосхонов Асрорхон Аббосхон угли
JurnalЖурнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research
NashriyotБухоро давлат тиббиёт институти
Nashr sanasi2026-06-22
Jild7
Son4
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

симптоматическая эпилепсия, ферроптоз, метаболизм железа, GPX4, когнитивные нарушения, нейровизуализация, symptomatic epilepsy, ferroptosis, iron metabolism, GPX4, cognitive impairment, neuroimaging, simptomatik epilepsiya, ferroptoz, temir almashinuvi, GPX4, kognitiv buzilishlar, neyrovizualizatsiya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAАзизова Раъно Баходировна, & Аббосхонов Асрорхон Аббосхон угли (2026). THE ROLE OF FERROPTOSIS IN THE PATHOGENESIS OF SYMPTOMATIC EPILEPSY: A CLINICAL AND NEUROIMAGING STUDY. Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(4). https://tadqiqot.uz/index.php/neurology/article/view/14301
GOST (OAK)Азизова Раъно Баходировна, Аббосхонов Асрорхон Аббосхон угли THE ROLE OF FERROPTOSIS IN THE PATHOGENESIS OF SYMPTOMATIC EPILEPSY: A CLINICAL AND NEUROIMAGING STUDY // Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research. – 2026. – T. 7, № 4.
MLAАзизова Раъно Баходировна, and Аббосхонов Асрорхон Аббосхон угли. “THE ROLE OF FERROPTOSIS IN THE PATHOGENESIS OF SYMPTOMATIC EPILEPSY: A CLINICAL AND NEUROIMAGING STUDY.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(4), 2026. https://tadqiqot.uz/index.php/neurology/article/view/14301
ChicagoАзизова Раъно Баходировна, and Аббосхонов Асрорхон Аббосхон угли. “THE ROLE OF FERROPTOSIS IN THE PATHOGENESIS OF SYMPTOMATIC EPILEPSY: A CLINICAL AND NEUROIMAGING STUDY.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(4) (2026). https://tadqiqot.uz/index.php/neurology/article/view/14301
HarvardАзизова Раъно Баходировна, and Аббосхонов Асрорхон Аббосхон угли (2026) ‘THE ROLE OF FERROPTOSIS IN THE PATHOGENESIS OF SYMPTOMATIC EPILEPSY: A CLINICAL AND NEUROIMAGING STUDY’, Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(4). https://tadqiqot.uz/index.php/neurology/article/view/14301
BibTeX
@article{article2026,
  title = {THE ROLE OF FERROPTOSIS IN THE PATHOGENESIS OF SYMPTOMATIC EPILEPSY: A CLINICAL AND NEUROIMAGING STUDY},
  author = {Азизова Раъно Баходировна and Аббосхонов Асрорхон Аббосхон угли},
  journal = {Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research},
  year = {2026},
  volume = {7},
  number = {4},
  url = {https://tadqiqot.uz/index.php/neurology/article/view/14301}
}

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