Hypoxic-ischemic brain damage in children is one of the most serious problems in modern neonatology and pediatric neurology. According to the World Health Organization, hypoxic-ischemic encephalopathy (HIE) occurs in 1-3 newborns per 1000 live births in developed countries and up to 26 per 1000 live births in developing regions, being the leading cause of neonatal mortality and long-term neurological disability. Hypoxic-ischemic damage occurs as a result of insufficient oxygen supply and impaired cerebral circulation, leading to a cascade of pathobiochemical processes, including energy deficiency, exitotoxicity, oxidative stress, neural inflammation, and programmed cell death. The particular vulnerability of the developing brain to hypoxic-ischemic effects is due to the immaturity of the blood-brain barrier, the high metabolic activity of nerve tissue, and active myelination processes.
| Mualliflar | Джурабекова Азиза Тоҳировна, Исанова Шоира Тулкиновна, Холикулова Махбуба Анвар кизи |
|---|---|
| Jurnal | Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research |
| Nashr sanasi | 2025-12-12 |
| Jild | 6 |
| Son | 6/2 |
| Til | Rus |
гипоксически-ишемическое повреждение мозга, дети, новорожденные, нейробиомаркеры, нейрон-специфическая енолаза, белок S100B, тау-протеин, гипоксически-ишемическая энцефалопатия, магнитно-резонансная томография, диффузионно-взвешенная МРТ, электроэнцефалография, нейровизуализация, перинатальная неврология, неонатология, прогнозирование исходов, ранняя диагностика, нейропротекция, hypoxic-ischemic brain damage, children, newborns, neurobiomarker, neuron-specific enolase, S100B protein, tau protein, hypoxic-ischemic encephalopathy, magnetic resonance imaging, diffusion-weighted MRI, electroencephalography, neurovisualization, perinatal neurology, neonatology, outcome prediction, early diagnosis, neuroprotection, миянинг гипоксик-ишемик зарарланиши, болалар, чақалоқлар, нейробиомаркерлар, нейрон-специфик энолаза, С100Б оқсили, таю-протеин, гипоксик-ишемик энцефалопатия, магнитли-резонанс томографияси, диффузион-тортилган МРТ, электроэнцефалография, нейротасвирлаш, перинатал неврология, неонатология, оқибатларни башорат қилиш, эрта ташхислаш, нейроҳимоя
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