Efficacy of neuroprotective drugs in the treatment of patients with ischemic stroke: modern strategies

Адамбаев Зуфар Ибрагимович, Киличев Ибодулла Абдуллаевич, Сапарбаев Кудрат Исмаилович

Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-yil

Annotatsiya

The problem of ischemic stroke remains highly relevant in modern neurology due to its high mortality, morbidity, and social burden. Although reperfusion therapy (thrombolysis, thrombectomy) is the gold standard, its application is limited by a narrow time window and a number of contraindications. This necessitates the development and implementation of effective neuroprotective drugs aimed at blocking the pathophysiological cascades of secondary brain damage. The aim of this article is to conduct a systematic analysis of modern neuroprotection strategies for ischemic stroke. Key pathogenesis targets are reviewed, including excitotoxicity, oxidative stress, inflammation, and energy failure. The evidence base for the efficacy and safety of both classical neuroprotectors (e.g., antioxidants, glutamate receptor blockers) and new, experimental approaches (agents affecting mitochondrial dysfunction, poly(ADP-ribose) polymerase inhibitors, stem cells) is analyzed. Special attention is paid to the reasons for the failure of translating preclinical results into clinical practice and the prospects for creating polymodal therapeutic regimens that combine reperfusion and neuroprotection.

Maqola ma’lumotlari
MualliflarАдамбаев Зуфар Ибрагимович, Киличев Ибодулла Абдуллаевич, Сапарбаев Кудрат Исмаилович
JurnalЖурнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research
NashriyotБухоро давлат тиббиёт институти
Nashr sanasi2025-09-12
Jild6
Son5
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

ишемический инсульт, патогенез ишемического инсульта, нейропротекция, ischemic stroke, pathogenesis of ischemic stroke, neuroprotection, ishemik insult, ishemik insult patogenezi, neyroproteksiya,

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAАдамбаев Зуфар Ибрагимович, Киличев Ибодулла Абдуллаевич, & Сапарбаев Кудрат Исмаилович (2025). EFFICACY OF NEUROPROTECTIVE DRUGS IN THE TREATMENT OF PATIENTS WITH ISCHEMIC STROKE: MODERN STRATEGIES. Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(5). https://tadqiqot.uz/index.php/neurology/article/view/12340
GOST (OAK)Адамбаев Зуфар Ибрагимович, Киличев Ибодулла Абдуллаевич, Сапарбаев Кудрат Исмаилович EFFICACY OF NEUROPROTECTIVE DRUGS IN THE TREATMENT OF PATIENTS WITH ISCHEMIC STROKE: MODERN STRATEGIES // Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research. – 2025. – T. 6, № 5.
MLAАдамбаев Зуфар Ибрагимович, Киличев Ибодулла Абдуллаевич, and Сапарбаев Кудрат Исмаилович. “EFFICACY OF NEUROPROTECTIVE DRUGS IN THE TREATMENT OF PATIENTS WITH ISCHEMIC STROKE: MODERN STRATEGIES.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(5), 2025. https://tadqiqot.uz/index.php/neurology/article/view/12340
ChicagoАдамбаев Зуфар Ибрагимович, Киличев Ибодулла Абдуллаевич, and Сапарбаев Кудрат Исмаилович. “EFFICACY OF NEUROPROTECTIVE DRUGS IN THE TREATMENT OF PATIENTS WITH ISCHEMIC STROKE: MODERN STRATEGIES.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(5) (2025). https://tadqiqot.uz/index.php/neurology/article/view/12340
HarvardАдамбаев Зуфар Ибрагимович, Киличев Ибодулла Абдуллаевич, and Сапарбаев Кудрат Исмаилович (2025) ‘EFFICACY OF NEUROPROTECTIVE DRUGS IN THE TREATMENT OF PATIENTS WITH ISCHEMIC STROKE: MODERN STRATEGIES’, Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(5). https://tadqiqot.uz/index.php/neurology/article/view/12340
BibTeX
@article{article2025,
  title = {EFFICACY OF NEUROPROTECTIVE DRUGS IN THE TREATMENT OF PATIENTS WITH ISCHEMIC STROKE: MODERN STRATEGIES},
  author = {Адамбаев Зуфар Ибрагимович and Киличев Ибодулла Абдуллаевич and Сапарбаев Кудрат Исмаилович},
  journal = {Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research},
  year = {2025},
  volume = {6},
  number = {5},
  url = {https://tadqiqot.uz/index.php/neurology/article/view/12340}
}

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