Neurosyphilis is a form of late syphilis with central nervous system involvement that remains relevant in the era of modern antibiotic therapy. In recent decades, against the background of the HIV epidemic and the increasing number of immunocompromised patients, there has been an increase in cases of neurosyphilis. Clinical manifestations of the disease are very diverse - from asymptomatic forms to severe neurodegenerative processes observed in progressive paralysis and tabes dorsalis. Modern diagnostic methods, including cerebrospinal fluid (CSF) analysis and molecular genetic studies, allow for early detection of neurosyphilis. Despite the widespread use of antibiotic therapy, insufficient treatment efficacy is noted in some cases, which increases the relevance of studying this pathology.
Maqola ma’lumotlari
Mualliflar
Абзоиров Кудрат Мусульмонкулович
Jurnal
Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research
Мирджураев Эльбек Миршавкатович, Адамбаев Зуфар Ибрагимович, Маматханова Чарос Баходировна · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
Cervical myelopathy (CM) is a progressive neurological disorder caused by spinal cord compression in the cervical spine. The pathophysiology of CM is complex and involves a cascade of events such as spinal cord…
Адамбаев Зуфар Ибрагимович, Киличев Ибодулла Абдуллаевич, Сапарбаев Кудрат Исмаилович · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
The problem of ischemic stroke remains highly relevant in modern neurology due to its high mortality, morbidity, and social burden. Although reperfusion therapy (thrombolysis, thrombectomy) is the gold standard, its…
Кудратова Нигора Бурхоновна, Абдуллаева Наргиза Нурмаматовна, Камалова Малика Ильхомовна · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
Today, migraine is one of the most common and disabling neurological diseases. Migraine occurs 3 times more often in women than in men and affects 18-25% of women of fertile age. Hormonal changes, especially…
Мурадимова Альфия Рашидовна · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
This article presents a systematic review of the fundamental factors influencing the rehabilitation potential of patients after cerebral stroke. It examines the biological and clinical prerequisites for recovery, modern…
Сафаров Комилжон Камолович, Хайдарова Дилдора Кодировна · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
Parkinson's disease (PD) is one of the most common neurodegenerative diseases characterized by the progressive loss of dopaminergic neurons in the brain's substantia nigra. Traditionally, the diagnosis of Parkinson's…
Гульнара Саттаровна Рахимбаева, Дилшодахон Турдикуловна Акрамова · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
This article analyzes the relationship between monocyte-attracting chemical protein-1 (CCL2) levels and clinical indicators in Parkinson's disease and parkinsonism plus syndromes. Serum protein levels were compared with…
Саидвалиев Фаррух Саидакрамович, Пулатова Дилёра Рустамовна, Хамидов Абдулахад Абдисаттарович · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
150 patients were examined with Parkinson’s disease. All participants underwent a comprehensive clinical, neurological, and neuropsychological evaluation, including measurement of serotonin and dopamine levels in blood…
Рахматуллаева Гулнара Кутпитдиновна, Кадырова Азиза Шавкатовна · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
Objective. To evaluate the prognostic significance of genetic markers of thrombophilia in the development of ischemic stroke in women, taking into account age stratification.Materials and Methods. A total of 97 women…
Обидов Фаррух Хамитович, Мавлянова Зилола Фархадовна, Ким Ольга Анатольевна · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
The article presents the results of determining the pathophysiological relationships between biomarkers of inflammation (IL-6, TNF-α, CRP), oxidative stress (MDA, homocysteine), neurodegeneration (NSE) and neurotrophic…
Дилшода Турдикуловна Акрамова · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
This study investigates the relationship between serum neurofilament light chain levels and clinical parameters in patients with Parkinson’s disease and Parkinsonism syndromes. The analysis included motor and cognitive…