Parkinson's disease (PD) is one of the most common neurodegenerative diseases characterized by the progressive loss of dopaminergic neurons in the brain's substantia nigra. Traditionally, the diagnosis of Parkinson's disease was based on the identification of classical motor symptoms - resting tremor, rigidity, bradykinesia, and postural instability. However, modern studies show that the pathological process in PD begins long before the manifestation of motor disorders, passing through the prodromal and early stages of the disease.
Саидвалиев Фаррух Саидакрамович, Пулатова Дилёра Рустамовна, Хамидов Абдулахад Абдисаттарович · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
150 patients were examined with Parkinson’s disease. All participants underwent a comprehensive clinical, neurological, and neuropsychological evaluation, including measurement of serotonin and dopamine levels in blood…
Кудратова Нигора Бурхоновна, Абдуллаева Наргиза Нурмаматовна, Камалова Малика Ильхомовна · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
Today, migraine is one of the most common and disabling neurological diseases. Migraine occurs 3 times more often in women than in men and affects 18-25% of women of fertile age. Hormonal changes, especially…
Обидов Фаррух Хамитович, Мавлянова Зилола Фархадовна, Ким Ольга Анатольевна · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
The article presents the results of determining the pathophysiological relationships between biomarkers of inflammation (IL-6, TNF-α, CRP), oxidative stress (MDA, homocysteine), neurodegeneration (NSE) and neurotrophic…
Мирджураев Эльбек Миршавкатович, Адамбаев Зуфар Ибрагимович, Маматханова Чарос Баходировна · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
Cervical myelopathy (CM) is a progressive neurological disorder caused by spinal cord compression in the cervical spine. The pathophysiology of CM is complex and involves a cascade of events such as spinal cord…
Ходжиева Дилбар Таджиевна, Жураева Дилсора Нуриддиновна · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
We visited Bukhara region, Jondor District Medical Association, Central Polyclinic, where 92 patients with trigeminal neuralgia aged 17 to 70 years and 30 patients in the control group were prescribed interleukin -4…
Абзоиров Кудрат Мусульмонкулович · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
Neurosyphilis is a form of late syphilis with central nervous system involvement that remains relevant in the era of modern antibiotic therapy. In recent decades, against the background of the HIV epidemic and the…
ХУДОЙБЕРДИЕВА Диловар Имомназарова, НИЯЗОВ Шухрат Тошемирович · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
Progressive multifocal leukoencephalopathy (PML) has always been among the urgent issues in neurology and pediatrics, both in research and practice. In particular, neurological practice deals significantly with…
Адамбаев Зуфар Ибрагимович, Киличев Ибодулла Абдуллаевич, Сапарбаев Кудрат Исмаилович · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
The problem of ischemic stroke remains highly relevant in modern neurology due to its high mortality, morbidity, and social burden. Although reperfusion therapy (thrombolysis, thrombectomy) is the gold standard, its…
Хайдарова Дилдора Кадировна, Сулаймонов Муроджон Насирович · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
Postherpetic neuralgia (PHN) represents one of the most severe complications of herpes zoster, characterized by persistent pain syndrome that significantly reduces patients' quality of life. Traditional approaches to…
Мурадимова Альфия Рашидовна · Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-09-12
This article presents a systematic review of the fundamental factors influencing the rehabilitation potential of patients after cerebral stroke. It examines the biological and clinical prerequisites for recovery, modern…