This study investigated the effects of NOS3 gene polymorphisms T786C and Glu298Asp on vascular reactivity in patients with concurrent ischemic heart disease (IHD) and type 2 diabetes mellitus (T2DM). A total of 92 patients underwent genotyping via PCR and brachial artery duplex ultrasonography. Parameters measured included arterial diameters before and after reactive hyperemia, mean blood flow velocity, resistance and pulsatility indices, flow-mediated dilation, and vascular reactivity coefficient. Carriers ofT/C and Glu/Asp genotypes exhibited significantly reduced vascular responsiveness compared to homozygotes. These results underscore the pathogenic role of N0S3 polymorphisms in endothelial dysfunction among patients with IHD and T2DM.
| Mualliflar | Абдуллаева, Ч, Жураев, М, Рахмонов, Р, Abdullayeva, Ch, Jo‘rayev , M, Rahmonov, R, Abdullayeva, Ch, Jo‘rayev , M, Rahmonov, R |
|---|---|
| Jurnal | Тиббиёт ва спорт |
| Nashr sanasi | 2026-06-15 |
| Son | 3 |
| Betlar | 88-91 |
| Til | O‘zbek |
ишемическая болезнь сердца, сахарный диабет 2 типа, эндотелиальная дисфункция, оксид азота, полиморфизмы гена NOS3, ischemic heart disease, type 2 diabetes mellitus, endothelial dysfunction, nitric oxide, NOS3 gene polymorphisms, yurak ishemik kasalligi, 2-tip qandli diabet, endotelial disfunktsiya, azot oksidi, NOS3 genining polimorfizmlari
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