Association of neurological complications with hyperhomocysteinemia in children with juvenile rheumatoid arthritis

Хамидова Нодира Абдужаббаровна, Маджидова Якутхон Набиевна

Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-yil

Annotatsiya

The pathogenesis of juvenile rheumatoid arthritis (JRA) is a complex process in which genetic, immune, and environmental factors interact. One aspect that has attracted research attention is the role of homocysteine, an amino acid resulting from the metabolism of methionine. One of the key mechanisms through which homocysteine may contribute to the development of SUR is its influence on inflammatory processes. Elevated levels of homocysteine can activate macrophages and other cells of the immune system, leading to the release of proinflammatory cytokines (e.g., interleukins and tumor necrosis factor). These molecules play a central role in the pathogenesis of inflammatory diseases, including arthritis. It is hypothesized that elevated homocysteine levels may contribute to the development of autoimmune reactions. This may occur through activation of T-lymphocytes and formation of antibodies against the body's own tissues. In the case of JRA, this can cause the immune system to attack the body's own joints, causing them to become inflamed and damaged. Homocysteine also plays a role in the pathogenesis of vascular disease. It can cause endothelial dysfunction and promote blood clot formation. These changes may affect the blood supply to joints, which exacerbates inflammatory processes and promotes arthritic changes.

Maqola ma’lumotlari
MualliflarХамидова Нодира Абдужаббаровна, Маджидова Якутхон Набиевна
JurnalЖурнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research
NashriyotБухоро давлат тиббиёт институти
Nashr sanasi2025-05-18
Jild6
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

Сосудистый эндотелий, сывороточный гомоцистеин, лимфоциты, аутоиммунная реакция, Vascular endothelium, serum homocysteine, lymphocytes, autoimmune reaction, qon tomir endoteliyasi, serum gomosistein, limfotsitlar, autoimmun reaksiya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAХамидова Нодира Абдужаббаровна, & Маджидова Якутхон Набиевна (2025). ASSOCIATION OF NEUROLOGICAL COMPLICATIONS WITH HYPERHOMOCYSTEINEMIA IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS. Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(3). https://tadqiqot.uz/index.php/neurology/article/view/11393
GOST (OAK)Хамидова Нодира Абдужаббаровна, Маджидова Якутхон Набиевна ASSOCIATION OF NEUROLOGICAL COMPLICATIONS WITH HYPERHOMOCYSTEINEMIA IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS // Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research. – 2025. – T. 6, № 3.
MLAХамидова Нодира Абдужаббаровна, and Маджидова Якутхон Набиевна. “ASSOCIATION OF NEUROLOGICAL COMPLICATIONS WITH HYPERHOMOCYSTEINEMIA IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(3), 2025. https://tadqiqot.uz/index.php/neurology/article/view/11393
ChicagoХамидова Нодира Абдужаббаровна, and Маджидова Якутхон Набиевна. “ASSOCIATION OF NEUROLOGICAL COMPLICATIONS WITH HYPERHOMOCYSTEINEMIA IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(3) (2025). https://tadqiqot.uz/index.php/neurology/article/view/11393
HarvardХамидова Нодира Абдужаббаровна, and Маджидова Якутхон Набиевна (2025) ‘ASSOCIATION OF NEUROLOGICAL COMPLICATIONS WITH HYPERHOMOCYSTEINEMIA IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS’, Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(3). https://tadqiqot.uz/index.php/neurology/article/view/11393
BibTeX
@article{article2025,
  title = {ASSOCIATION OF NEUROLOGICAL COMPLICATIONS WITH HYPERHOMOCYSTEINEMIA IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS},
  author = {Хамидова Нодира Абдужаббаровна and Маджидова Якутхон Набиевна},
  journal = {Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research},
  year = {2025},
  volume = {6},
  number = {3},
  url = {https://tadqiqot.uz/index.php/neurology/article/view/11393}
}

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