Perinatal damage to the central nervous system (PDCNS) is one of the leading causes of neurological pathologies in newborns and young children. The study of the etiopathogenesis of this pathology plays a major role in the development of effective prevention, early diagnosis and treatment strategies. The pathogenesis of PDCNS is based on such factors as hypoxic-ischemic, infectious-inflammatory, toxic-metabolic and traumatic, which disrupt the formation and functioning of the central nervous system during critical periods of development. Modern research focuses on the molecular and genetic aspects, the role of inflammatory mediators, oxidative stress, and protective mechanisms of the nervous system. A deep understanding of the etiopathogenesis of PDCNS opens up new perspectives for the development of innovative therapies aimed at reducing the risk of long-term neurological consequences.
| Mualliflar | Aллаев Марат Эркинбоевич, Киличев Ибодулла Абдуллаевич, Бобожонов Зафарбек Одилбекович |
|---|---|
| Jurnal | Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research |
| Nashr sanasi | 2025-05-18 |
| Jild | 6 |
| Son | 3 |
| Til | Rus |
этиопатогенез, перинатальные поражения, гипоксически-ишемические поражения, etiopathogenesis, perinatal lesions, hypoxic-ischemic lesions, этиопатогенез, перинатал шикастланишлар, гипоксик-ишемик бузилишлар
The pathogenesis of juvenile rheumatoid arthritis (JRA) is a complex process in which genetic, immune, and environmental factors interact. One aspect that has attracted research attention is the role of homocysteine, an…
Post-hemodialysis encephalopathy (PHE) refers to neurological changes that can occur in the brain of patients with chronic kidney disease after undergoing hemodialysis. These changes can lead to impairments in brain…
In patients with initial manifestations of cerebral blood supply insufficiency endonasal electrophoresis with tanacan (EGb 761) has a positive effect not only on the clinical condition of patients, but also on…
Objective. Based on the literature analysis, to study the mechanisms of development, clinical course, structure of precancerous diseases of the uterus in women of fertile age, to analyze the psychopathological state…
A total of 118 patients with epilepsy and intellectual/developmental disabilities were examined. All patients underwent molecular genetic testing to confirm/exclude mutations in the sodium channel genes - SCN1A, SCN2A…
Neuroinflammation plays a crucial role in the pathogenesis of autism spectrum disorders (ASD), representing a complex process that includes the activation of immune cells in the brain, an imbalance of pro-inflammatory…
Treatment of migraine in pregnant women is a complex clinical challenge that requires an optimal balance between therapeutic efficacy and safety for mother and fetus. This article presents a differentiated approach to…
The article presents the specificity of blood coagulation parameters such as hematocrit, thrombin time, fibrinogen, etalon test, thrombotest in hemorrhagic stroke and type 2 diabetes mellitus, and the dependence of…
Cerebral palsy (CP) remains one of the most common causes of childhood disability worldwide, with an incidence of 2-3 cases per 1,000 live births. The modern concept of providing care for children with cerebral palsy…
The article presents clinical cases with a diagnosis of congenital and acquired microcephaly encountered in our work. We believe that it is necessary to conduct a study on this nosology based on a deep analysis…