Low indication of papp-a and afp markers, high indication of β-hCG marker as predictors of congenital somatic and neurological anomalies

Ишанходжаева Гулчехра Талиповна, Ибодов Бекзод Абдусаттарович, Мирзоев Жавоҳир Баходирович, Расулова Ирода Тубли қизи

Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2023-yil

Annotatsiya

Currently, the number of congenital diseases is increasing significantly. In order to prevent and treat the next generation of these congenital diseases, congenital disease markers play an important role as predictors. For example, abberant concentrations of PAPP-a, AFP and hCG are one of the most important predictors of congenital diseases. Therefore, we decided to explain in detail the etiology and mechanism of how a pathological change in the concentration of these markers can cause congenital diseases. Pregnancy-associated plasma protein A (PAPP-A) is a key regulator of the bioavailability of insulin-like growth factor, essential for normal fetal development. Alpha-fetoprotein (AFP) is a plasma protein produced by the embryonic yolk sac and fetal liver. AFP levels in serum, amniotic fluid and urine serve as a screening test for birth defects, chromosomal abnormalities. Human chorionic gonadotropin is a hormone produced predominantly by placental syncytiotrophoblastic cells during pregnancy. Measuring hCG levels can be helpful in detecting normal pregnancies, abnormal pregnancies, and can also be helpful after aborted pregnancies.

Maqola ma’lumotlari
MualliflarИшанходжаева Гулчехра Талиповна, Ибодов Бекзод Абдусаттарович, Мирзоев Жавоҳир Баходирович, Расулова Ирода Тубли қизи
JurnalЖурнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research
NashriyotБухоро давлат тиббиёт институти
Nashr sanasi2023-02-03
Jild4
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

Врожденные пороки развития; PAPP-a; АФП; β-ХГЧ; задержка развития плода; гестоз; хромосомная аберрация, Congenital malformations; PAPP-a; AFP; β-hCG; delayed fetal development; preeclampsia; chromosomal aberration, Эмбрионал туғма нуқсонлар, PAPP-a, AFP, β-hCG ҳомила ривожланиши кечикиши, преэклампсия, хромосомал аберацияси

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAИшанходжаева Гулчехра Талиповна, Ибодов Бекзод Абдусаттарович, Мирзоев Жавоҳир Баходирович, & Расулова Ирода Тубли қизи (2023). LOW INDICATION OF PAPP-A AND AFP MARKERS, HIGH INDICATION OF β-hCG MARKER AS PREDICTORS OF CONGENITAL SOMATIC AND NEUROLOGICAL ANOMALIES. Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 4(1). https://tadqiqot.uz/index.php/neurology/article/view/6696
GOST (OAK)Ишанходжаева Гулчехра Талиповна va b. LOW INDICATION OF PAPP-A AND AFP MARKERS, HIGH INDICATION OF β-hCG MARKER AS PREDICTORS OF CONGENITAL SOMATIC AND NEUROLOGICAL ANOMALIES // Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research. – 2023. – T. 4, № 1.
MLAИшанходжаева Гулчехра Талиповна, Ибодов Бекзод Абдусаттарович, Мирзоев Жавоҳир Баходирович, and Расулова Ирода Тубли қизи. “LOW INDICATION OF PAPP-A AND AFP MARKERS, HIGH INDICATION OF β-hCG MARKER AS PREDICTORS OF CONGENITAL SOMATIC AND NEUROLOGICAL ANOMALIES.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 4(1), 2023. https://tadqiqot.uz/index.php/neurology/article/view/6696
ChicagoИшанходжаева Гулчехра Талиповна, Ибодов Бекзод Абдусаттарович, Мирзоев Жавоҳир Баходирович, and Расулова Ирода Тубли қизи. “LOW INDICATION OF PAPP-A AND AFP MARKERS, HIGH INDICATION OF β-hCG MARKER AS PREDICTORS OF CONGENITAL SOMATIC AND NEUROLOGICAL ANOMALIES.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 4(1) (2023). https://tadqiqot.uz/index.php/neurology/article/view/6696
HarvardИшанходжаева Гулчехра Талиповна, Ибодов Бекзод Абдусаттарович, Мирзоев Жавоҳир Баходирович, and Расулова Ирода Тубли қизи (2023) ‘LOW INDICATION OF PAPP-A AND AFP MARKERS, HIGH INDICATION OF β-hCG MARKER AS PREDICTORS OF CONGENITAL SOMATIC AND NEUROLOGICAL ANOMALIES’, Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 4(1). https://tadqiqot.uz/index.php/neurology/article/view/6696
BibTeX
@article{article2023,
  title = {LOW INDICATION OF PAPP-A AND AFP MARKERS, HIGH INDICATION OF β-hCG MARKER AS PREDICTORS OF CONGENITAL SOMATIC AND NEUROLOGICAL ANOMALIES},
  author = {Ишанходжаева Гулчехра Талиповна and Ибодов Бекзод Абдусаттарович and Мирзоев Жавоҳир Баходирович and Расулова Ирода Тубли қизи},
  journal = {Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research},
  year = {2023},
  volume = {4},
  number = {1},
  url = {https://tadqiqot.uz/index.php/neurology/article/view/6696}
}

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