The GPX4 gene (located at 19p13.3) is located in the 3' untranslated region (3'UTR), and the functionally significant C718T (rs713041) polymorphism is highly associated with diabetes mellitus. Mutations in this regulatory region are known to affect messenger RNA (mRNA) stability, translation efficiency, and ultimately the concentration of active enzyme in the cell. Substitution of cytosine (C) for thymine (T) is associated with decreased GPX4 enzyme activity. This article presents important aspects of this gene in patients with diabetic angiopathy.
| Mualliflar | MAMADIYAROVA Dilshoda Umirzokovna, Azimova Sevara Bakhodirovna |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2026-08-07 |
| Jild | 11 |
| Son | 3 |
| Til | Rus |
Ген GPX4, полиморфизм C718T (RS713041), диабетическая ангиопатия, окислительная система, антиоксидантная система, повреждение сосудов, GPX4 gene, C718T (RS713041) polymorphism, diabetic angiopathy, oxidative system, antioxidant system, vascular damage, GPX4 geni, C718T (RS713041) polimorfizmi, diabetik angiopatiya, oksidlovchi tizim, antioksidant tizim, qon-tomir shikastlanishi
Цель исследования. Изучить влияние мелатонина в патогенезе нарушений сна и гликемического контроля у пациентов репродуктивного возраста с сахарным диабетом 2 типа (СД2), а также оценить эффективность мелатонинотерапии в…
Purpose of the study: to identify risk factors for the development of parastomal complications in the early postoperative period. Materials and methods: The study included 272 patients who underwent surgical treatment…
Objective. To evaluate serum BMP-7 levels in patients with type 2 diabetes mellitus (T2DM) and to assess their associations with clinical and laboratory parameters according to chronic kidney disease (CKD) phenotypes…
Postoperative ventral hernia (PVH) is commonly observed in patients with obesity. Obesity contributes to increased intra-abdominal pressure, which in turn leads to the development of PVH. The choice of surgical staging…
Surgical treatment of postoperative ventral hernias of the anterior abdominal wall remains one of the urgent problems of clinical surgery. According to current statistical data, postoperative hernias develop in 5–14% of…
Objective. To identify clinical and morphological predictors of persistent urinary incontinence after radical prostatectomy based on the analysis of urological and oncological risk factors. Materials and Methods. A…
At the present time, the role of the male factor in infertile marriage is about 40%. To elucidate causes of infertility an important role plays determining the size of the external genitalia (genitometria), and…
Injuries and strictures (narrowing) of the female urethra are rare but clinically significant conditions that may be accompanied by impaired urodynamics, chronic inflammatory processes and secondary complications…
The generally accepted idea of “Cystic neoplasms”, due to the introduction of computed tomography into medical practice, consists of simple cysts, benign cysts, cysts with multiple septa, doubtful cysts (unclear whether…
Post-osteomyelitic diaphyseal defects of the femur are among the most complex complications in traumatology and orthopedic practice, frequently leading to disability. Chronic osteomyelitis in this region is often…
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