The GPX4 gene (located at 19p13.3) is located in the 3' untranslated region (3'UTR), and the functionally significant C718T (rs713041) polymorphism is highly associated with diabetes mellitus. Mutations in this regulatory region are known to affect messenger RNA (mRNA) stability, translation efficiency, and ultimately the concentration of active enzyme in the cell. Substitution of cytosine (C) for thymine (T) is associated with decreased GPX4 enzyme activity. This article presents important aspects of this gene in patients with diabetic angiopathy.
| Mualliflar | MAMADIYAROVA Dilshoda Umirzokovna, Azimova Sevara Bakhodirovna |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashriyot | Тошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ |
| ISSN | 2181-9300 |
| Nashr sanasi | 2026-08-07 |
| Jild | 11 |
| Son | 3 |
| Til | Ingliz |
| Ilmiy soha | Tibbiyot |
| Indeksga qo‘shilgan | 2026-08-27 |
Ген GPX4, полиморфизм C718T (RS713041), диабетическая ангиопатия, окислительная система, антиоксидантная система, повреждение сосудов, GPX4 gene, C718T (RS713041) polymorphism, diabetic angiopathy, oxidative system, antioxidant system, vascular damage, GPX4 geni, C718T (RS713041) polimorfizmi, diabetik angiopatiya, oksidlovchi tizim, antioksidant tizim, qon-tomir shikastlanishi
| APA | MAMADIYAROVA Dilshoda Umirzokovna, & Azimova Sevara Bakhodirovna (2026). THE SIGNIFICANCE OF THE C718T (RS713041) POLYMORPHISM IN THE GPX4 GENE IN TYPE 2 DIABETES MELLITUS COMPLICATED BY ANGIOPATHY. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14781 |
|---|---|
| GOST (OAK) | MAMADIYAROVA Dilshoda Umirzokovna, Azimova Sevara Bakhodirovna THE SIGNIFICANCE OF THE C718T (RS713041) POLYMORPHISM IN THE GPX4 GENE IN TYPE 2 DIABETES MELLITUS COMPLICATED BY ANGIOPATHY // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 3. |
| MLA | MAMADIYAROVA Dilshoda Umirzokovna, and Azimova Sevara Bakhodirovna. “THE SIGNIFICANCE OF THE C718T (RS713041) POLYMORPHISM IN THE GPX4 GENE IN TYPE 2 DIABETES MELLITUS COMPLICATED BY ANGIOPATHY.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/14781 |
| Chicago | MAMADIYAROVA Dilshoda Umirzokovna, and Azimova Sevara Bakhodirovna. “THE SIGNIFICANCE OF THE C718T (RS713041) POLYMORPHISM IN THE GPX4 GENE IN TYPE 2 DIABETES MELLITUS COMPLICATED BY ANGIOPATHY.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/14781 |
| Harvard | MAMADIYAROVA Dilshoda Umirzokovna, and Azimova Sevara Bakhodirovna (2026) ‘THE SIGNIFICANCE OF THE C718T (RS713041) POLYMORPHISM IN THE GPX4 GENE IN TYPE 2 DIABETES MELLITUS COMPLICATED BY ANGIOPATHY’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14781 |
| BibTeX | @article{mamadiyarovadilshodaumirzokovna2026,
title = {THE SIGNIFICANCE OF THE C718T (RS713041) POLYMORPHISM IN THE GPX4 GENE IN TYPE 2 DIABETES MELLITUS COMPLICATED BY ANGIOPATHY},
author = {MAMADIYAROVA Dilshoda Umirzokovna and Azimova Sevara Bakhodirovna},
journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
year = {2026},
volume = {11},
number = {3},
url = {https://tadqiqot.uz/index.php/biomedicine/article/view/14781}
} |
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