Effect of immunosuppressive regimens on the relapse rate and cumulative corticosteroid dose in children with frequently recurrent nephrotic syndrome

KHAMZAEV Komiljon Amirovich, BONDARENKO Anastasiya Romanovna, AKHMATALIEVA Mayram

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Background: Frequently relapsing nephrotic syndrome (FRNS) represent major challenges in pediatric nephrology due to repeated relapses and prolonged corticosteroid therapy that may cause significant adverse effects. Objective: To evaluate the effectiveness of two mycophenolate‑based immunosuppressive regimens in reducing relapse frequency and cumulative corticosteroid exposure in children with FRNS. Methods: A prospective cohort study included 89 children with nephrotic syndrome. Patients were treated with either mycophenolate mofetil (MMF) + tacrolimus + prednisolone (n=34) or mycophenolate mofetil + prednisolone (n=55). Clinical variables analyzed included relapse frequency, cumulative prednisolone dose, demographic characteristics, and histopathological findings. Results: Both treatment regimens were associated with a significant reduction in relapse frequency and cumulative steroid exposure. Mean relapse number decreased from 6.7 to 2.0 episodes in the triple‑therapy group and from 3.9 to 0.9 episodes in the MMF + prednisolone group. Conclusion: Mycophenolate‑based immunosuppressive therapy significantly reduces relapse frequency and corticosteroid exposure in children with FRNS.

Maqola ma’lumotlari
MualliflarKHAMZAEV Komiljon Amirovich, BONDARENKO Anastasiya Romanovna, AKHMATALIEVA Mayram
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-05-19
Jild11
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

нефротический синдром у детей, такролимус, микофенолата мофетил, стероидозависимый нефротический синдром, pediatric nephrotic syndrome, tacrolimus, mycophenolate mofetil, steroid‑dependent nephrotic syndrome

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKHAMZAEV Komiljon Amirovich, BONDARENKO Anastasiya Romanovna, & AKHMATALIEVA Mayram (2026). EFFECT OF IMMUNOSUPPRESSIVE REGIMENS ON THE RELAPSE RATE AND CUMULATIVE CORTICOSTEROID DOSE IN CHILDREN WITH FREQUENTLY RECURRENT NEPHROTIC SYNDROME. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2). https://tadqiqot.uz/index.php/biomedicine/article/view/13859
GOST (OAK)KHAMZAEV Komiljon Amirovich, BONDARENKO Anastasiya Romanovna, AKHMATALIEVA Mayram EFFECT OF IMMUNOSUPPRESSIVE REGIMENS ON THE RELAPSE RATE AND CUMULATIVE CORTICOSTEROID DOSE IN CHILDREN WITH FREQUENTLY RECURRENT NEPHROTIC SYNDROME // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 2.
MLAKHAMZAEV Komiljon Amirovich, BONDARENKO Anastasiya Romanovna, and AKHMATALIEVA Mayram. “EFFECT OF IMMUNOSUPPRESSIVE REGIMENS ON THE RELAPSE RATE AND CUMULATIVE CORTICOSTEROID DOSE IN CHILDREN WITH FREQUENTLY RECURRENT NEPHROTIC SYNDROME.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13859
ChicagoKHAMZAEV Komiljon Amirovich, BONDARENKO Anastasiya Romanovna, and AKHMATALIEVA Mayram. “EFFECT OF IMMUNOSUPPRESSIVE REGIMENS ON THE RELAPSE RATE AND CUMULATIVE CORTICOSTEROID DOSE IN CHILDREN WITH FREQUENTLY RECURRENT NEPHROTIC SYNDROME.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13859
HarvardKHAMZAEV Komiljon Amirovich, BONDARENKO Anastasiya Romanovna, and AKHMATALIEVA Mayram (2026) ‘EFFECT OF IMMUNOSUPPRESSIVE REGIMENS ON THE RELAPSE RATE AND CUMULATIVE CORTICOSTEROID DOSE IN CHILDREN WITH FREQUENTLY RECURRENT NEPHROTIC SYNDROME’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2). https://tadqiqot.uz/index.php/biomedicine/article/view/13859
BibTeX
@article{khamzaevkomiljonamirovich2026,
  title = {EFFECT OF IMMUNOSUPPRESSIVE REGIMENS ON THE RELAPSE RATE AND CUMULATIVE CORTICOSTEROID DOSE IN CHILDREN WITH FREQUENTLY RECURRENT NEPHROTIC SYNDROME},
  author = {KHAMZAEV Komiljon Amirovich and BONDARENKO Anastasiya Romanovna and AKHMATALIEVA Mayram},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {2},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13859}
}

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