Synthetic cathinones (SC), a prominent class of new psychoactive substances (NPS), have gained increasing popularity in illicit drug markets. Their widespread availability and perceived legal status contribute to rising consumption rates, despite emerging evidence of severe psychiatric consequences. Among these, suicidality remains a significant concern. However, research on the association between synthetic cathinone use and suicidal behavior remains limited. This study aimed to investigate the relationship between SC use and suicidality risk. Methods. An observational retrospective cohort study was conducted at the Republican Specialized Scientific-Practical Medical Center of Mental Health in Uzbekistan between 2022 and 2024. A total of 138 patients diagnosed with substance use disorders were included, stratified into two groups: main group (n = 98): patients with synthetic cathinone dependence (ICD-10 code F15.2); comparison group (n = 40): patients dependent on other psychostimulants. Data were collected through clinical records, structured clinical interviews, and standardized questionnaires, including the Columbia-Suicide Severity Rating Scale (C-SSRS). Odds ratios (OR), relative risks (RR), and the number needed to treat (NNT) were calculated to assess the association between SC use and suicidality.Results. The findings revealed a significant association between Alfa-PVP use and increased suicidality risk (OR = 2.76, 95% CI: 1.19–6.39, p = 0.026; RR = 2.07, 95% CI: 1.09–3.95, p = 0.026). The NNT for harm (4.97) suggests that for every five individuals using Alfa-PVP, one additional case of high suicidality occurs. Conclusions. The results underscore Alfa-PVP as a substance of concern, given its strong association with suicidality, necessitating increased clinical monitoring. Further research is required to explore underlying mechanisms and validate these findings through adjusted models and prospective studies.
| Mualliflar | RAVSHANOV Jakhongir Ravshanovich, ASHUROV Zarifjon |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2026-05-19 |
| Jild | 11 |
| Son | 2 |
| Til | Ingliz |
синтетические катиноны, Альфа-ПВП, суицидальное поведение, новые психоактивные вещества, расстройства, связанные с употреблением ПАВ, synthetic cathinones, Alfa-PVP, suicidality, new psychoactive substances (NPS), substance use disorders., sintetik katinonlar, Alfa-PVP, suitsidal xulq-atvor, yangi psixoaktiv moddalar, moddalar iste’moli buzilishlari.
In recent years, dorsopathies have gained increasing significance due to their rising prevalence among young patients. In individuals under 40 years of age, chronic pain in the lumbar and cervical regions, as well as…
Background: Frequently relapsing nephrotic syndrome (FRNS) represent major challenges in pediatric nephrology due to repeated relapses and prolonged corticosteroid therapy that may cause significant adverse effects…
In recent decades, depressive disorders have gained significant scientific and practical importance. This is associated with the high prevalence of depression and its negative impact on patients’ quality of life…
Introduction. Steroid-resistant nephrotic syndrome (SRNS) carries a high risk of progression to end-stage renal disease. Next-generation sequencing (NGS) has shown that a significant proportion of pediatric cases have a…
The increasing prevalence of synthetic narcotic substances and psychoactive pharmaceutical drug use has become a significant public health concern. This study analyzes trends in substance use in Uzbekistan from 2022 to…
Introduction. Nephrotic syndrome (NS) is one of the most common glomerular diseases in childhood. Although corticosteroids remain the cornerstone of initial therapy, approximately 50% of affected children develop…
Aim - to evaluate the effectiveness of conservative treatment of intervertebral disc herniation using physiotherapeutic procedures. Materials and methods: An analysis of the results of inpatient treatment of 98 patients…
According to 2024 data, chronic kidney disease in children ranges from 15 to 74.7 cases per million children. Objective: To study the characteristics of iron indices depending on the variant of anemic syndrome course…
Relevance. Cerebral palsy (CP) is one of the leading causes of childhood disability requiring long-term multidisciplinary rehabilitation. The limitations of conventional approaches necessitate the implementation of…
Objective. To assess the relationship between the level of digital visual load, the severity of Digital Asthenopic Syndrome (DAS), accommodative function parameters, and cognitive performance in school-aged children…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar