The impact of synthetic cathinones on suicidal behavior: a retrospective analysis of patients with dependence

RAVSHANOV Jakhongir Ravshanovich, ASHUROV Zarifjon

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Synthetic cathinones (SC), a prominent class of new psychoactive substances (NPS), have gained increasing popularity in illicit drug markets. Their widespread availability and perceived legal status contribute to rising consumption rates, despite emerging evidence of severe psychiatric consequences. Among these, suicidality remains a significant concern. However, research on the association between synthetic cathinone use and suicidal behavior remains limited. This study aimed to investigate the relationship between SC use and suicidality risk. Methods. An observational retrospective cohort study was conducted at the Republican Specialized Scientific-Practical Medical Center of Mental Health in Uzbekistan between 2022 and 2024. A total of 138 patients diagnosed with substance use disorders were included, stratified into two groups: main group (n = 98): patients with synthetic cathinone dependence (ICD-10 code F15.2); comparison group (n = 40): patients dependent on other psychostimulants. Data were collected through clinical records, structured clinical interviews, and standardized questionnaires, including the Columbia-Suicide Severity Rating Scale (C-SSRS). Odds ratios (OR), relative risks (RR), and the number needed to treat (NNT) were calculated to assess the association between SC use and suicidality.Results. The findings revealed a significant association between Alfa-PVP use and increased suicidality risk (OR = 2.76, 95% CI: 1.19–6.39, p = 0.026; RR = 2.07, 95% CI: 1.09–3.95, p = 0.026). The NNT for harm (4.97) suggests that for every five individuals using Alfa-PVP, one additional case of high suicidality occurs. Conclusions. The results underscore Alfa-PVP as a substance of concern, given its strong association with suicidality, necessitating increased clinical monitoring. Further research is required to explore underlying mechanisms and validate these findings through adjusted models and prospective studies.

Maqola ma’lumotlari
MualliflarRAVSHANOV Jakhongir Ravshanovich, ASHUROV Zarifjon
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-05-19
Jild11
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

синтетические катиноны, Альфа-ПВП, суицидальное поведение, новые психоактивные вещества, расстройства, связанные с употреблением ПАВ, synthetic cathinones, Alfa-PVP, suicidality, new psychoactive substances (NPS), substance use disorders., sintetik katinonlar, Alfa-PVP, suitsidal xulq-atvor, yangi psixoaktiv moddalar, moddalar iste’moli buzilishlari.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APARAVSHANOV Jakhongir Ravshanovich, & ASHUROV Zarifjon (2026). THE IMPACT OF SYNTHETIC CATHINONES ON SUICIDAL BEHAVIOR: A RETROSPECTIVE ANALYSIS OF PATIENTS WITH DEPENDENCE. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2). https://tadqiqot.uz/index.php/biomedicine/article/view/13860
GOST (OAK)RAVSHANOV Jakhongir Ravshanovich, ASHUROV Zarifjon THE IMPACT OF SYNTHETIC CATHINONES ON SUICIDAL BEHAVIOR: A RETROSPECTIVE ANALYSIS OF PATIENTS WITH DEPENDENCE // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 2.
MLARAVSHANOV Jakhongir Ravshanovich, and ASHUROV Zarifjon. “THE IMPACT OF SYNTHETIC CATHINONES ON SUICIDAL BEHAVIOR: A RETROSPECTIVE ANALYSIS OF PATIENTS WITH DEPENDENCE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13860
ChicagoRAVSHANOV Jakhongir Ravshanovich, and ASHUROV Zarifjon. “THE IMPACT OF SYNTHETIC CATHINONES ON SUICIDAL BEHAVIOR: A RETROSPECTIVE ANALYSIS OF PATIENTS WITH DEPENDENCE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13860
HarvardRAVSHANOV Jakhongir Ravshanovich, and ASHUROV Zarifjon (2026) ‘THE IMPACT OF SYNTHETIC CATHINONES ON SUICIDAL BEHAVIOR: A RETROSPECTIVE ANALYSIS OF PATIENTS WITH DEPENDENCE’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2). https://tadqiqot.uz/index.php/biomedicine/article/view/13860
BibTeX
@article{ravshanovjakhongirravshanovich2026,
  title = {THE IMPACT OF SYNTHETIC CATHINONES ON SUICIDAL BEHAVIOR: A RETROSPECTIVE ANALYSIS OF PATIENTS WITH DEPENDENCE},
  author = {RAVSHANOV Jakhongir Ravshanovich and ASHUROV Zarifjon},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {2},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13860}
}

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