Significance of IL10 RS1800872, SERPINE1 RS1799768, NOS3 RS2070744, and IL1Β RS1143627 gene polymorphisms in purulent-necrotic processes of the maxillofacial region

BOYMURODOV Shukhrat Abdujalilovich, KURBANOV Yoqubjon Khamdamovich, YUSUPOV Shokhrukh Shuhratovich, DJURAYEV Jamolbek Abdukakharovich, SOATOV Ilyosjon Olimovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

This study is devoted to determining the pathogenetic significance of IL10 rs1800872, SERPINE1 rs1799768, NOS3 rs2070744, and IL1β rs1143627 gene polymorphisms in purulent-necrotic processes of the maxillofacial region developing under the influence of various etiological factors. The results of molecular genetic analyses demonstrated that these genes play an important role in the regulation of inflammatory processes, disturbances of microcirculation, the formation of thrombogenic states, and alterations of the immune response. Polymorphisms of the IL10 gene affect the efficiency of anti-inflammatory mechanisms, potentially contributing to a more severe course of necrotic processes. Variants of the SERPINE1 and NOS3 genes are associated with endothelial dysfunction and impaired tissue perfusion. Polymorphisms of the IL1β gene are characterized by excessive activation of inflammatory mediators. The obtained results indicate the promising potential of these genetic markers for early diagnosis of purulent-necrotic lesions of the maxillofacial region, identification of high-risk groups, and development of individualized therapeutic strategies.

Maqola ma’lumotlari
MualliflarBOYMURODOV Shukhrat Abdujalilovich, KURBANOV Yoqubjon Khamdamovich, YUSUPOV Shokhrukh Shuhratovich, DJURAYEV Jamolbek Abdukakharovich, SOATOV Ilyosjon Olimovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-04-22
Jild11
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

гнойно-некротические процессы челюстно-лицевой области, генетический полиморфизм, IL10, SERPINE1, молекулярная генетика, purulent-necrotic processes of the maxillofacial region, gene polymorphism, IL10, SERPINE1, molecular genetics, : yuz-jag‘ sohasida yiringli nekroz, gen polimorfizmi, IL10, SERPINE1, molekulyar genetika

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Iqtibos keltirish

APABOYMURODOV Shukhrat Abdujalilovich, KURBANOV Yoqubjon Khamdamovich, YUSUPOV Shokhrukh Shuhratovich, DJURAYEV Jamolbek Abdukakharovich, & SOATOV Ilyosjon Olimovich (2026). SIGNIFICANCE OF IL10 RS1800872, SERPINE1 RS1799768, NOS3 RS2070744, AND IL1Β RS1143627 GENE POLYMORPHISMS IN PURULENT-NECROTIC PROCESSES OF THE MAXILLOFACIAL REGION. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1). https://tadqiqot.uz/index.php/biomedicine/article/view/13483
GOST (OAK)BOYMURODOV Shukhrat Abdujalilovich va b. SIGNIFICANCE OF IL10 RS1800872, SERPINE1 RS1799768, NOS3 RS2070744, AND IL1Β RS1143627 GENE POLYMORPHISMS IN PURULENT-NECROTIC PROCESSES OF THE MAXILLOFACIAL REGION // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 1.
MLABOYMURODOV Shukhrat Abdujalilovich, KURBANOV Yoqubjon Khamdamovich, YUSUPOV Shokhrukh Shuhratovich, DJURAYEV Jamolbek Abdukakharovich, and SOATOV Ilyosjon Olimovich. “SIGNIFICANCE OF IL10 RS1800872, SERPINE1 RS1799768, NOS3 RS2070744, AND IL1Β RS1143627 GENE POLYMORPHISMS IN PURULENT-NECROTIC PROCESSES OF THE MAXILLOFACIAL REGION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13483
ChicagoBOYMURODOV Shukhrat Abdujalilovich, KURBANOV Yoqubjon Khamdamovich, YUSUPOV Shokhrukh Shuhratovich, DJURAYEV Jamolbek Abdukakharovich, and SOATOV Ilyosjon Olimovich. “SIGNIFICANCE OF IL10 RS1800872, SERPINE1 RS1799768, NOS3 RS2070744, AND IL1Β RS1143627 GENE POLYMORPHISMS IN PURULENT-NECROTIC PROCESSES OF THE MAXILLOFACIAL REGION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13483
HarvardBOYMURODOV Shukhrat Abdujalilovich, KURBANOV Yoqubjon Khamdamovich, YUSUPOV Shokhrukh Shuhratovich, DJURAYEV Jamolbek Abdukakharovich, and SOATOV Ilyosjon Olimovich (2026) ‘SIGNIFICANCE OF IL10 RS1800872, SERPINE1 RS1799768, NOS3 RS2070744, AND IL1Β RS1143627 GENE POLYMORPHISMS IN PURULENT-NECROTIC PROCESSES OF THE MAXILLOFACIAL REGION’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1). https://tadqiqot.uz/index.php/biomedicine/article/view/13483
BibTeX
@article{boymurodovshukhratabdujalilovich2026,
  title = {SIGNIFICANCE OF IL10 RS1800872, SERPINE1 RS1799768, NOS3 RS2070744, AND IL1Β RS1143627 GENE POLYMORPHISMS IN PURULENT-NECROTIC PROCESSES OF THE MAXILLOFACIAL REGION},
  author = {BOYMURODOV Shukhrat Abdujalilovich and KURBANOV Yoqubjon Khamdamovich and YUSUPOV Shokhrukh Shuhratovich and DJURAYEV Jamolbek Abdukakharovich and SOATOV Ilyosjon Olimovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {1},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13483}
}

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