Neuroendocrine mechanisms of comorbidity between anxiety-depressive disorders and hypothyroidism

MAGZUMOVA Shakhnoza, VOSIQOV Botirbek Abdullaziz o‘g‘li

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

This review explores the neuroendocrine mechanisms underlying the comorbidity of anxiety and depressive disorders with hypothyroidism. It summarizes current data on the impact of thyroid dysfunction on the central nervous system, including the interaction of thyroid hormones with neurotransmitter systems and the stress axis, as well as the role of autoimmune inflammation. Epidemiological studies confirming an increased risk of affective disorders in hypothyroidism, particularly in its manifest form, are presented. The phenomenon of "sickness behavior" is discussed as an adaptive response to hormonal deficiency. Key pathogenic pathways are outlined, explaining how thyroid hormone deficiency and accompanying immune alterations can contribute to the development of depression and anxiety. The conclusion emphasizes the multifactorial nature of this comorbidity and the necessity of an interdisciplinary approach to its understanding.

Maqola ma’lumotlari
MualliflarMAGZUMOVA Shakhnoza, VOSIQOV Botirbek Abdullaziz o‘g‘li
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-11-03
Jild10
Son4
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

гипотиреоз; депрессия; тревожное расстройство; нейроэндокринная коморбидность; тиреоидные гормоны; аутоиммунный тиреоидит, hypothyroidism; depression; anxiety disorder; neuroendocrine comorbidity; thyroid hormones; autoimmune thyroiditis, gipotireoz; depressiya; xavotir; neyroendokrin komorbidlik; qalqonsimon bez gormonlari; autoimmun tireoidit

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAMAGZUMOVA Shakhnoza, & VOSIQOV Botirbek Abdullaziz o‘g‘li (2025). NEUROENDOCRINE MECHANISMS OF COMORBIDITY BETWEEN ANXIETY-DEPRESSIVE DISORDERS AND HYPOTHYROIDISM. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(4). https://tadqiqot.uz/index.php/biomedicine/article/view/12760
GOST (OAK)MAGZUMOVA Shakhnoza, VOSIQOV Botirbek Abdullaziz o‘g‘li NEUROENDOCRINE MECHANISMS OF COMORBIDITY BETWEEN ANXIETY-DEPRESSIVE DISORDERS AND HYPOTHYROIDISM // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 10, № 4.
MLAMAGZUMOVA Shakhnoza, and VOSIQOV Botirbek Abdullaziz o‘g‘li. “NEUROENDOCRINE MECHANISMS OF COMORBIDITY BETWEEN ANXIETY-DEPRESSIVE DISORDERS AND HYPOTHYROIDISM.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(4), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/12760
ChicagoMAGZUMOVA Shakhnoza, and VOSIQOV Botirbek Abdullaziz o‘g‘li. “NEUROENDOCRINE MECHANISMS OF COMORBIDITY BETWEEN ANXIETY-DEPRESSIVE DISORDERS AND HYPOTHYROIDISM.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(4) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/12760
HarvardMAGZUMOVA Shakhnoza, and VOSIQOV Botirbek Abdullaziz o‘g‘li (2025) ‘NEUROENDOCRINE MECHANISMS OF COMORBIDITY BETWEEN ANXIETY-DEPRESSIVE DISORDERS AND HYPOTHYROIDISM’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(4). https://tadqiqot.uz/index.php/biomedicine/article/view/12760
BibTeX
@article{magzumovashakhnoza2025,
  title = {NEUROENDOCRINE MECHANISMS OF COMORBIDITY BETWEEN ANXIETY-DEPRESSIVE DISORDERS AND HYPOTHYROIDISM},
  author = {MAGZUMOVA Shakhnoza and VOSIQOV Botirbek Abdullaziz o‘g‘li},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {10},
  number = {4},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/12760}
}

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