This study investigates the immunological status of 140 newborns presenting with various forms of neonatal pathology, with particular attention to serum levels of circulating immune complexes (CIC) and immunoglobulins of classes A, M, and G (IgA, IgM, IgG). The highest CIC concentrations were detected in neonates diagnosed with intrauterine pneumonia (IUP) (153,4 ± 0,93 conventional units), followed by those with neonatal pneumonia (NP) (157,3 ± 0,91) and purulent-inflammatory diseases (PID) (141,2 ± 0,84). These elevated CIC values are indicative of significant antigenic load, most likely acquired in utero. A statistically significant inverse correlation was observed between CIC levels and total complement activity (CH50), which was notably reduced in all pathological groups: 45,1 units in IUP, 44,3 units in NP, and 41,2 units in PID, compared to the reference value of 50,4 units. This decrease is presumed to result from complement consumption during the formation of immune complexes in the course of antigen -antibody interactions. Assessment of serum Ig G concentrations revealed a marked reduction in neonates with NP (5,0 ± 0,32 g/l) and a further decline in those with PID (3,8 ± 0,32 g/l), while relatively higher levels were maintained in the IUP group (5,0 ± 0,34 g/l). These findings suggest compromised transplacental transfer of maternal IgG and support the presence of intrauterine infection as a contributing etiological factor.
| Mualliflar | SIROJIDDINOVA Khiromon Nuriddinovna |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2025-10-31 |
| Jild | 10 |
| Son | 4 |
| Til | O‘zbek |
circulating immune complexes, complement system, immunoglobulins, neonates, intrauterine infection, aylanma immun komplekslar, komplement, immunoglobulinlar, yangi tug'ilgan chaqaloqlar
Preeclampsia is a formidable disease that occurs in women after the 20th week of pregnancy and is accompanied by a triad of symptoms. These symptoms include edema, increased blood pressure and proteinuria. Untimely…
This review explores the convergence of molecular, regenerative, and digital technologies in gynecology following the COVID-19 pandemic. Emphasis is placed on exosome-based liquid biopsy, mesenchymal stem cell therapy…
In December 2019, a new respiratory infection caused by a previously unidentified strain of coronavirus, named SARS-CoV-2, was identified in China. This virus belongs to the Coronaviridae family, Nidovirales, and is…
Objective To assess hygiene awareness among pregnant women with chronic urological conditions and outline preventive actions. Materials and Methods. An anonymous questionnaire survey was conducted at the Kattaqo‘rg‘on…
Current evidence suggests that MMP and TIMP gene polymorphisms may have a significant impact on the degree of inflammation and structural changes in the myocardium during viral infections, including COVID-19. However…
Thyroid hypofunction in reproductive age has an impact on the possibility of conception and health of women. Hypothyroidism affects the menstrual cycle, follicular development, embryogenesis, implantation and placenta…
Allergic diseases remain one of the most pressing issues in pediatrics. The number of children with allergic pathologies continues to grow, with bronchial asthma (BA) being the leading condition among them. Asthma is…
Ovarian torsion is an urgent condition and has been an indication for ovarian removal for many years, but in recent years there have been studies on organ-preserving tactics in adolescents. Objective. to substantiate…
Pneumonia continues to occupy a leading place in the structure of general and respiratory morbidity and mortality among children. Considering its impact on the immune system and inflammatory processes, it is advisable…
With the onset of the COVID-19 pandemic, researchers began to investigate the pathogenetic mechanisms causing the infection and its complications, to analyze…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar