Pathogenetic values of immune complexes during intrauterine infection

SIROJIDDINOVA Khiromon Nuriddinovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

This study investigates the immunological status of 140 newborns presenting with various forms of neonatal pathology, with particular attention to serum levels of circulating immune complexes (CIC) and immunoglobulins of classes A, M, and G (IgA, IgM, IgG). The highest CIC concentrations were detected in neonates diagnosed with intrauterine pneumonia (IUP) (153,4 ± 0,93 conventional units), followed by those with neonatal pneumonia (NP) (157,3 ± 0,91) and purulent-inflammatory diseases (PID) (141,2 ± 0,84). These elevated CIC values are indicative of significant antigenic load, most likely acquired in utero. A statistically significant inverse correlation was observed between CIC levels and total complement activity (CH50), which was notably reduced in all pathological groups: 45,1 units in IUP, 44,3 units in NP, and 41,2 units in PID, compared to the reference value of 50,4 units. This decrease is presumed to result from complement consumption during the formation of immune complexes in the course of antigen -antibody interactions. Assessment of serum Ig G concentrations revealed a marked reduction in neonates with NP (5,0 ± 0,32 g/l) and a further decline in those with PID (3,8 ± 0,32 g/l), while relatively higher levels were maintained in the IUP group (5,0 ± 0,34 g/l). These findings suggest compromised transplacental transfer of maternal IgG and support the presence of intrauterine infection as a contributing etiological factor.

Maqola ma’lumotlari
MualliflarSIROJIDDINOVA Khiromon Nuriddinovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-10-31
Jild10
Son4
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

circulating immune complexes, complement system, immunoglobulins, neonates, intrauterine infection, aylanma immun komplekslar, komplement, immunoglobulinlar, yangi tug'ilgan chaqaloqlar

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APASIROJIDDINOVA Khiromon Nuriddinovna (2025). PATHOGENETIC VALUES OF IMMUNE COMPLEXES DURING INTRAUTERINE INFECTION. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(4). https://tadqiqot.uz/index.php/biomedicine/article/view/12683
GOST (OAK)SIROJIDDINOVA Khiromon Nuriddinovna PATHOGENETIC VALUES OF IMMUNE COMPLEXES DURING INTRAUTERINE INFECTION // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 10, № 4.
MLASIROJIDDINOVA Khiromon Nuriddinovna. “PATHOGENETIC VALUES OF IMMUNE COMPLEXES DURING INTRAUTERINE INFECTION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(4), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/12683
ChicagoSIROJIDDINOVA Khiromon Nuriddinovna. “PATHOGENETIC VALUES OF IMMUNE COMPLEXES DURING INTRAUTERINE INFECTION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(4) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/12683
HarvardSIROJIDDINOVA Khiromon Nuriddinovna (2025) ‘PATHOGENETIC VALUES OF IMMUNE COMPLEXES DURING INTRAUTERINE INFECTION’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(4). https://tadqiqot.uz/index.php/biomedicine/article/view/12683
BibTeX
@article{sirojiddinovakhiromonnuriddinovna2025,
  title = {PATHOGENETIC VALUES OF IMMUNE COMPLEXES DURING INTRAUTERINE INFECTION},
  author = {SIROJIDDINOVA Khiromon Nuriddinovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {10},
  number = {4},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/12683}
}

Boshqa maqola uchun iqtibos tayyorlash

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali jurnalidan boshqa maqolalar

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar · 2025-yil arxivi

Tibbiyot sohasidagi boshqa maqolalar

Tibbiyot sohasidagi OAK jurnallari