Lymphocyte profile as an indicator of metastatic breast cancer progression

TILLASHAYXOV Mirzagolib Nigmatovich, SHAKHANOVA Shakhnoza Shavkatovna, ESHMURODOV Uktam Makhmudovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

Objective: To analyze lymphocyte subpopulation dynamics and prognostic value in 127 metastatic breast cancer patients with liver involvement undergoing chemoimmunotherapy (2016–2022) at the Samarkand Oncology Center.Methods: A retrospective-prospective observational study. Collected 3067 CBCs, 1116 biochemical, and 1247 coagulation assays. Identified three lymphocyte change patterns: descending, stable, and wave-like.Results: Descending pattern in 41 patients (32.3%): lymphocyte decline from 35.0% to 30.5% (Δ=4.5%, p<0.05, R²>0.85) indicating progressive lymphopenia and immunosuppression. Stable pattern in 35 patients (27.6%): minor fluctuations between 33.0%–34.5%, preserving immune homeostasis. Wave-like pattern in 51 patients (40.2%): cyclical variations from 29.0% to 34.5% (amplitude 5.5%), reflecting adaptive immune responses post-chemotherapy cycles.Conclusion: Stable dynamics align with optimal tolerance to standard ESMO/NCCN chemotherapy. Wave-like type suggests phased immune restoration. Descending pattern necessitates early immunostimulatory interventions.

Maqola ma’lumotlari
MualliflarTILLASHAYXOV Mirzagolib Nigmatovich, SHAKHANOVA Shakhnoza Shavkatovna, ESHMURODOV Uktam Makhmudovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-09-08
Jild10
Son3/2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

лимфоцитарный профиль, метастатический рак, прогрессия опухоли, иммунный статус, : lymphocyte profile, metastatic cancer, tumor progression, immune status, limfositlar profili, metastatik saraton, o'sma progressiyasi, immunitet holati

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APATILLASHAYXOV Mirzagolib Nigmatovich, SHAKHANOVA Shakhnoza Shavkatovna, & ESHMURODOV Uktam Makhmudovich (2025). LYMPHOCYTE PROFILE AS AN INDICATOR OF METASTATIC BREAST CANCER PROGRESSION. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3/2). https://tadqiqot.uz/index.php/biomedicine/article/view/12288
GOST (OAK)TILLASHAYXOV Mirzagolib Nigmatovich, SHAKHANOVA Shakhnoza Shavkatovna, ESHMURODOV Uktam Makhmudovich LYMPHOCYTE PROFILE AS AN INDICATOR OF METASTATIC BREAST CANCER PROGRESSION // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 10, № 3/2.
MLATILLASHAYXOV Mirzagolib Nigmatovich, SHAKHANOVA Shakhnoza Shavkatovna, and ESHMURODOV Uktam Makhmudovich. “LYMPHOCYTE PROFILE AS AN INDICATOR OF METASTATIC BREAST CANCER PROGRESSION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3/2), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/12288
ChicagoTILLASHAYXOV Mirzagolib Nigmatovich, SHAKHANOVA Shakhnoza Shavkatovna, and ESHMURODOV Uktam Makhmudovich. “LYMPHOCYTE PROFILE AS AN INDICATOR OF METASTATIC BREAST CANCER PROGRESSION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3/2) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/12288
HarvardTILLASHAYXOV Mirzagolib Nigmatovich, SHAKHANOVA Shakhnoza Shavkatovna, and ESHMURODOV Uktam Makhmudovich (2025) ‘LYMPHOCYTE PROFILE AS AN INDICATOR OF METASTATIC BREAST CANCER PROGRESSION’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(3/2). https://tadqiqot.uz/index.php/biomedicine/article/view/12288
BibTeX
@article{tillashayxovmirzagolibnigmatovich2025,
  title = {LYMPHOCYTE PROFILE AS AN INDICATOR OF METASTATIC BREAST CANCER PROGRESSION},
  author = {TILLASHAYXOV Mirzagolib Nigmatovich and SHAKHANOVA Shakhnoza Shavkatovna and ESHMURODOV Uktam Makhmudovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {10},
  number = {3/2},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/12288}
}

Boshqa maqola uchun iqtibos tayyorlash

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali jurnalidan boshqa maqolalar

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar · 2025-yil arxivi

TILLASHAYXOV Mirzagolib Nigmatovich — boshqa maqolalari

Tibbiyot sohasidagi boshqa maqolalar

Tibbiyot sohasidagi OAK jurnallari