Morphological picture of bone marrow in patients in the early period after allogeneic hematopoietic cell transplantation

ACHILOVA Ozoda Umarkulovna, KAYUMOV Abdurakhman Abdumavljanovich, MAKHAMADALIEVA Gulchekhra Zukhriddinovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

Haemoblastosis is one of the most pressing medical problems. Bone marrow transplantation (BMT) is currently a reliable method of tumor eradication in leukemia. Despite the fact that the history of transplantation spans more than 50 years, the issues of bone marrow repair after allogeneic and autologous transplantation are poorly studied. The purpose of the study. To study the morphological picture of the bone marrow according to trepanobioptates in early post-transplant period in patient with acute leukemia. Materials and methods. A morphological analysis of trepanobioptates of 30 patients after alloBMT performed at the RSSPMCH in the period from 2023 to 2024 was carried out. Results. From the data obtained, it can be seen that even after alloBMT in this group of patients, the cellularity of the bone morrow in none of the patients reached normal values on day +30. 22(74%) patients had normocellular by day +30. In 8(26%) cases, clearly defined hypocellularity was noted in bone morrow. The ratio between adipose bone marrow and myelocaryocytes prevailed towards adipose tissue was 0.5:0.9 — which indicates hypoplasia of hematopoiesis. Decreasing of the cellularity in 1/3 of patients occurred even within 60 days, which manifested itself in 7(23%) as three-stage cytopenia. Conclusion. From all this, it can be concluded that despite the relatively stable peripheral blood parameters, it is still too early to talk about complete bone marrow repair even at +60 days after BMT.

Maqola ma’lumotlari
MualliflarACHILOVA Ozoda Umarkulovna, KAYUMOV Abdurakhman Abdumavljanovich, MAKHAMADALIEVA Gulchekhra Zukhriddinovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-02-12
Jild9
Son6
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

аллотрансплантация костного мозга, клетки костного мозга, трепанобиопсия, восстановление кроветворения, allogenic bone marrow transplantation, bone marrow cellularity, trepanobiopsy, hematopoiesis restoration, suyak iligi allotransplantatsiyasi, suyak iligi hujayralari, trepanobiopsiya, gematopoezni tiklash

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAACHILOVA Ozoda Umarkulovna, KAYUMOV Abdurakhman Abdumavljanovich, & MAKHAMADALIEVA Gulchekhra Zukhriddinovna (2025). MORPHOLOGICAL PICTURE OF BONE MARROW IN PATIENTS IN THE EARLY PERIOD AFTER ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(6). https://tadqiqot.uz/index.php/biomedicine/article/view/10934
GOST (OAK)ACHILOVA Ozoda Umarkulovna, KAYUMOV Abdurakhman Abdumavljanovich, MAKHAMADALIEVA Gulchekhra Zukhriddinovna MORPHOLOGICAL PICTURE OF BONE MARROW IN PATIENTS IN THE EARLY PERIOD AFTER ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 9, № 6.
MLAACHILOVA Ozoda Umarkulovna, KAYUMOV Abdurakhman Abdumavljanovich, and MAKHAMADALIEVA Gulchekhra Zukhriddinovna. “MORPHOLOGICAL PICTURE OF BONE MARROW IN PATIENTS IN THE EARLY PERIOD AFTER ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(6), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/10934
ChicagoACHILOVA Ozoda Umarkulovna, KAYUMOV Abdurakhman Abdumavljanovich, and MAKHAMADALIEVA Gulchekhra Zukhriddinovna. “MORPHOLOGICAL PICTURE OF BONE MARROW IN PATIENTS IN THE EARLY PERIOD AFTER ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(6) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/10934
HarvardACHILOVA Ozoda Umarkulovna, KAYUMOV Abdurakhman Abdumavljanovich, and MAKHAMADALIEVA Gulchekhra Zukhriddinovna (2025) ‘MORPHOLOGICAL PICTURE OF BONE MARROW IN PATIENTS IN THE EARLY PERIOD AFTER ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(6). https://tadqiqot.uz/index.php/biomedicine/article/view/10934
BibTeX
@article{achilovaozodaumarkulovna2025,
  title = {MORPHOLOGICAL PICTURE OF BONE MARROW IN PATIENTS IN THE EARLY PERIOD AFTER ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION},
  author = {ACHILOVA Ozoda Umarkulovna and KAYUMOV Abdurakhman Abdumavljanovich and MAKHAMADALIEVA Gulchekhra Zukhriddinovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {9},
  number = {6},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/10934}
}

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