The article presents data on the participation of "epithelial-mesenchymal transitions" in the pathogenetic mechanism of adhesion process development in women who have undergone gynecological surgeries. The pathogenetic mechanism of participation of matrix metalloproteinases-2 and 9 and tumor necrosis factor-a in the development of adhesions in women who have undergone gynecological surgeries has been proven. Their high levels indicate a destructive effect on the extracellular matrix, creating conditions for the development of adhesions due to the growth of fibrous tissue. The range of MMP-2 levels >400 pg/ml, MMP-9 >350 pg/ml and TNF-α >45 pg/ml in determining the risk of adhesions after gynecological surgeries has been established.
| Mualliflar | ZUFAROVA Shakhnoza Alimdzhanovna, ESHDAVLATOV Ilkhom Eshniyazovich |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2025-02-11 |
| Jild | 9 |
| Son | 6 |
| Til | Rus |
женщины, спаечная болезнь, патогенез, матриксные металлопротеиназы, фактор некроза опухоли, women, adhesive disease, pathogenesis, matrix metalloproteinases, tumor necrosis factor, ayollar, bitishma kasallik, patogenez, matritsali metalloproteinazalar, o'simta nekrozi omili
Postpartum paresis is an acute, rapidly progressing, and severe disease characterized by a paralysis-like condition affecting the limbs, pharynx, and intestines, along with the suppression of both conditional and…
Infertility is often caused by congenital anomalies of sexual development and is associated with an unfavorable reproductive prognosis. In recent years, the development of assisted reproductive technologies has…
New methods of reproduction biotechnology are introduced in modern technologies livestock. These methods help significantly increase profitability. Unfortunately, these methods are introduced slowly, since they require…
The indications, contraindications and recurrence rate in the application of radiofrequency ablation (RFA) of myomatous nodes in patients with uterine myoma have been studied, which allows to select patients for this…
The article presents the results of a relatively modern literature in-depth analysis on the structure, chemical properties, as well as biological activity of this compound, which will allow the application of this…
More and more surgeries will be replaced by endoscopic surgeries, which will allow patients to receive high-quality care, but without unnecessary consequences such as postoperative pain, long recovery, and large scars…
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In connection with the above, the purpose of this study was to study the risk factors leading to the development of massive obstetric hemorrhage. An analysis of 302000 birth histories in the Samarkand region for…
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The work studied in vitro changes in starch digestibility when interacting with sunflower oil hydrolyzate as part of starch-fat substrates. As a result of the study, it was found that with increasing time of the joint…
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