Immunochemical evaluation of spinal cord injury biomarker S100B in experimental animal model

KhIKMATULAEV Rukhulla Zabikhullaevich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

The implementation of biomarkers in spinal cord injury (SCI) provides a useful tool to support clinical decision-making in the acute phase. S100b has been considered specific to the nervous system. In cases of SCI, this protein is released from nerve cells, and its concentration increases in the cerebrospinal fluid and blood under various CNS conditions. Over the past 20 years, several experimental and in vivo studies have been conducted on the prognostic role of S100b in tissues, serum or cerebrospinal fluid after SCI, which concluded that this biomarker could be a real-time indicator of early stages of spinal cord injury. S100b levels in serum and cerebrospinal fluid in experimental studies increased rapidly for a short time and then gradually decreased and reached normal levels a few days after injury. In addition, S100b has been studied as a predictor of initial spinal cord injury, which directly reflects the severity of SCI. Significant changes in serum S100b levels were also observed in patients with vertebral fractures and spinal cord injury. S100b protein may be a useful tool after spinal cord injury for early detection of the extent of spinal cord injury and the degree of neurological outcome within 14 days after injury.

Maqola ma’lumotlari
MualliflarKhIKMATULAEV Rukhulla Zabikhullaevich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-02-11
Jild9
Son6
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

белок S100B; травма спинного мозга; эксперимент; иммунохимия, S100B protein; spinal cord injury; experiment; immunochemistry, S100B oqsili; orqa miya jarohati; eksperiment; immunoximiya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKhIKMATULAEV Rukhulla Zabikhullaevich (2025). IMMUNOCHEMICAL EVALUATION OF SPINAL CORD INJURY BIOMARKER S100B IN EXPERIMENTAL ANIMAL MODEL. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(6). https://tadqiqot.uz/index.php/biomedicine/article/view/10918
GOST (OAK)KhIKMATULAEV Rukhulla Zabikhullaevich IMMUNOCHEMICAL EVALUATION OF SPINAL CORD INJURY BIOMARKER S100B IN EXPERIMENTAL ANIMAL MODEL // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 9, № 6.
MLAKhIKMATULAEV Rukhulla Zabikhullaevich. “IMMUNOCHEMICAL EVALUATION OF SPINAL CORD INJURY BIOMARKER S100B IN EXPERIMENTAL ANIMAL MODEL.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(6), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/10918
ChicagoKhIKMATULAEV Rukhulla Zabikhullaevich. “IMMUNOCHEMICAL EVALUATION OF SPINAL CORD INJURY BIOMARKER S100B IN EXPERIMENTAL ANIMAL MODEL.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(6) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/10918
HarvardKhIKMATULAEV Rukhulla Zabikhullaevich (2025) ‘IMMUNOCHEMICAL EVALUATION OF SPINAL CORD INJURY BIOMARKER S100B IN EXPERIMENTAL ANIMAL MODEL’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(6). https://tadqiqot.uz/index.php/biomedicine/article/view/10918
BibTeX
@article{khikmatulaevrukhullazabikhullaevich2025,
  title = {IMMUNOCHEMICAL EVALUATION OF SPINAL CORD INJURY BIOMARKER S100B IN EXPERIMENTAL ANIMAL MODEL},
  author = {KhIKMATULAEV Rukhulla Zabikhullaevich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {9},
  number = {6},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/10918}
}

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