Improvement of anti-inflammatory therapy for patients after coronary artery bypass grafting

YUSUPOV Jasur Tolibovich, MATLUBOV Mansur Muratovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2024-yil

Annotatsiya

An inflammatory response is likely to develop in all cardiac surgical patients operated on with or without cardiopulmonary bypass (CPB). With prolonged cardiac surgery and CPB, clinical manifestations develop in the form of increased capillary permeability, resulting in widespread edema, impaired gas exchange, cerebral, renal and hepatic dysfunctions.In this study, patients were divided into two groups, depending on the use of ulinastatin: group 1 (main) n= 35 patients who used ulinastatin in the intraoperative and early postoperative periods; Group 2 (control) – n = 30 patients who did not use ulinastatin in the intraoperative and early postoperative periods. In the complex of postoperative anti-inflammatory therapy to prevent organ damage and multiple organ dysfunction, it is necessary to include the use of a broad-spectrum protease inhibitor ulinastatin at a dose of 100,000 IU in 500 ml of 5% glucose solution or 0.9% sodium chloride intravenously drip for 1-2 hours on the 1st, 3rd day. Against the background of the use of ulinastatin, there was a decrease in the number of proinflammatory cytokines, in particular IL-6, in patients of the main group by 8±1.6 pg/ml (p<0.05), and in the control group there was an increase in the content of IL-6 by 15±3.6 pg/ml (p>0.05). Thus, the analysis shows a beneficial effect of ulinastatin on mortality, the frequency of postoperative complications, or the duration of stay in the intensive care unit after coronary artery bypass surgery.

Maqola ma’lumotlari
MualliflarYUSUPOV Jasur Tolibovich, MATLUBOV Mansur Muratovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2024-04-12
Jild9
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

ишемическая болезнь сердца, аортокоронарное шунтирование, искусственное кровообращение, цитокины, улинастатин, синдром системной воспалительной реакции, coronary heart disease, coronary artery bypass grafting, cardiopulmonary bypass, cytokines, ulinastatin, systemic inflammatory reaction syndrome, : yurak ishemik kasalligi, aorto koronar shuntlash, sitokinlar, sun’iy qon alanish, ulinastatin, tizimli yallig'lanish reaksiyasi sindromi

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAYUSUPOV Jasur Tolibovich, & MATLUBOV Mansur Muratovich (2024). IMPROVEMENT OF ANTI-INFLAMMATORY THERAPY FOR PATIENTS AFTER CORONARY ARTERY BYPASS GRAFTING. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(1). https://tadqiqot.uz/index.php/biomedicine/article/view/9227
GOST (OAK)YUSUPOV Jasur Tolibovich, MATLUBOV Mansur Muratovich IMPROVEMENT OF ANTI-INFLAMMATORY THERAPY FOR PATIENTS AFTER CORONARY ARTERY BYPASS GRAFTING // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2024. – T. 9, № 1.
MLAYUSUPOV Jasur Tolibovich, and MATLUBOV Mansur Muratovich. “IMPROVEMENT OF ANTI-INFLAMMATORY THERAPY FOR PATIENTS AFTER CORONARY ARTERY BYPASS GRAFTING.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(1), 2024. https://tadqiqot.uz/index.php/biomedicine/article/view/9227
ChicagoYUSUPOV Jasur Tolibovich, and MATLUBOV Mansur Muratovich. “IMPROVEMENT OF ANTI-INFLAMMATORY THERAPY FOR PATIENTS AFTER CORONARY ARTERY BYPASS GRAFTING.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(1) (2024). https://tadqiqot.uz/index.php/biomedicine/article/view/9227
HarvardYUSUPOV Jasur Tolibovich, and MATLUBOV Mansur Muratovich (2024) ‘IMPROVEMENT OF ANTI-INFLAMMATORY THERAPY FOR PATIENTS AFTER CORONARY ARTERY BYPASS GRAFTING’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(1). https://tadqiqot.uz/index.php/biomedicine/article/view/9227
BibTeX
@article{yusupovjasurtolibovich2024,
  title = {IMPROVEMENT OF ANTI-INFLAMMATORY THERAPY FOR PATIENTS AFTER CORONARY ARTERY BYPASS GRAFTING},
  author = {YUSUPOV Jasur Tolibovich and MATLUBOV Mansur Muratovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2024},
  volume = {9},
  number = {1},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/9227}
}

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