Significance of uromodulin in the development and progression of chronic kidney disease.

TOSHKENBAEVA Eleonora Negmatovna, ESANKULOV Mukhammad Olimovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2023-yil

Annotatsiya

Uromodulin (Tamm-Horsfall protein) is produced in the kidney by cells of the thick ascending limb and distal tubule. Recent genetic studies suggest a role of uromodulin in chronic kidney disease. Mutations in the UMOD gene cause uromodulin storage disease. They code for amino acid substitutions that lead to misfolding of the molecule and its retention in the endoplasmic reticulum. Single nucleotide polymorphisms in the region of the UMOD gene have been shown to be associated with chronic kidney disease and reduced glomerular filtration rate. These polymorphisms affect uromodulin concentration in the urine, and lower genetically determined urinary uromodulin concentrations seem to protect against renal disease. Chronic kidney disease is associated with higher serum levels of uromodulin. From animal experiments and human studies it is hypothesized that uromodulin entering the renal interstitium either by basolateral secretion or urinary back-leakage in damaged tubuli interacts with and stimulates cells of the immune system and thereby causes inflammation and progression of chronic kidney disease.

Maqola ma’lumotlari
MualliflarTOSHKENBAEVA Eleonora Negmatovna, ESANKULOV Mukhammad Olimovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2023-11-01
Jild8
Son4
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

уромодулин, белок Тамма-Хорсфалла, хроническая болезнь почек, генетика, мочевыводящие пути, Uromodulin, Tamm-Horsfall protein, Chronic kidney disease, genetic, urinary, Uromodulin, Tamm-Horsfall oqsili, Surunkali buyrak kasalligi, genetik, siydik

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APATOSHKENBAEVA Eleonora Negmatovna, & ESANKULOV Mukhammad Olimovich (2023). SIGNIFICANCE OF UROMODULIN IN THE DEVELOPMENT AND PROGRESSION OF CHRONIC KIDNEY DISEASE.. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 8(4). https://tadqiqot.uz/index.php/biomedicine/article/view/8296
GOST (OAK)TOSHKENBAEVA Eleonora Negmatovna, ESANKULOV Mukhammad Olimovich SIGNIFICANCE OF UROMODULIN IN THE DEVELOPMENT AND PROGRESSION OF CHRONIC KIDNEY DISEASE. // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2023. – T. 8, № 4.
MLATOSHKENBAEVA Eleonora Negmatovna, and ESANKULOV Mukhammad Olimovich. “SIGNIFICANCE OF UROMODULIN IN THE DEVELOPMENT AND PROGRESSION OF CHRONIC KIDNEY DISEASE..” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 8(4), 2023. https://tadqiqot.uz/index.php/biomedicine/article/view/8296
ChicagoTOSHKENBAEVA Eleonora Negmatovna, and ESANKULOV Mukhammad Olimovich. “SIGNIFICANCE OF UROMODULIN IN THE DEVELOPMENT AND PROGRESSION OF CHRONIC KIDNEY DISEASE..” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 8(4) (2023). https://tadqiqot.uz/index.php/biomedicine/article/view/8296
HarvardTOSHKENBAEVA Eleonora Negmatovna, and ESANKULOV Mukhammad Olimovich (2023) ‘SIGNIFICANCE OF UROMODULIN IN THE DEVELOPMENT AND PROGRESSION OF CHRONIC KIDNEY DISEASE.’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 8(4). https://tadqiqot.uz/index.php/biomedicine/article/view/8296
BibTeX
@article{toshkenbaevaeleonoranegmatovna2023,
  title = {SIGNIFICANCE OF UROMODULIN IN THE DEVELOPMENT AND PROGRESSION OF CHRONIC KIDNEY DISEASE.},
  author = {TOSHKENBAEVA Eleonora Negmatovna and ESANKULOV Mukhammad Olimovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2023},
  volume = {8},
  number = {4},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/8296}
}

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