The role of the G681A polymorphism of the CYP2C19 gene in the formation of male infertility was analyzed. The study was conducted on a sample of 140 patients with various clinical forms of male infertility and 155 conditionally healthy fertile men. Despite the involvement of this locus in the regulation of the synthesis of sex hormones, especially androgens, the carriage of an unfavorable variant of this gene does not have an independent phenotypic effect on male fertility disorders, which allows us to conclude that this gene does not play an independent role in the genesis of male fertility disorders.
| Mualliflar | IRGASHEV Dilmurod Saatovich, GASANOVA Shakhina Sardarovna, BOBOEV Kodirjon Tukhtabaevich |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2023-02-07 |
| Jild | 7 |
| Son | 6 |
| Til | Rus |
мужское бесплодие, полиморфизм G681A гена CYP2C19, аллель, генотип., male infertility, G681A polymorphism of the CYP2C19 gene, allele, genotype, erkaklar bepushtligi, CYP2C19 genining G681A polimorfizmi, allel, genotip
The article is devoted to the significance of the content of neutrophil elastase and interleukins (IL-1b, IL-17A) in the blood of patients with nonspecific interstitial pneumonia. The regulation of the inflammatory…
Research aim: to establish modifiable and unmodifiable risk factors for an unfavorable outcome of kidney transplantation. Materials and methods. The material of the study was 365 related kidney donors, who were observed…
At present, the trend of regular growth of phlegmon of the maxillofacial region with concomitant diseases is clearly visible. They have such features as a hyperergic inflammatory reaction, a long duration, and are…
A number of literature reports on changes in the gas composition of the blood in patients with pulmonary hypertension, which developed on the basis of chronic heart failure. But the blood gases seen in this cohort of…
The posterior urethral valve (PUV) is caused by the formation of congenital mucosal folds in the posterior urethra (prostatic and membranous parts), which as a result prevents complete emptying of the bladder. It is…
Objective: To evaluate the effectiveness of phosphargine succinate in patients with chronic brucellosis. Materials and methods: The object of the study were 85 patients aged 17 to 74 years who were treated at the…
Anorectal malformations in the world. Anorectal malformations (ARM) are one of the medical problems that lead to early disability. According to the World Health Organization (WHO), "... more than 303,000 children die…
When determining the socio-economic significance of a new coronavirus infection, the main approach is to assess the social and economic damage of the disease, taking into account the cost of all treatment and diagnostic…
Abdominal injury remains one of the most urgent problems in surgery, traumatology and resuscitation. At present, abdominal wounds make up 1.5-4.4% of all injuries. The structure of injuries varies due to accidents…
Respiratory disorders are one of the causes of death in foodborne botulism. Complications of food botulism are often associated with acute respiratory failure, although this is a natural stage of botulinum intoxication…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar