Thyroid Gland and Chronic Kidney Disease in Children

Karimdzhanov, Ilkhamdzhan, Rahmonberdiyeva, Matluba, Илхамджан, Рахмонбердиева, Матлуба, Karimdjanov, Ilxamdjan, Rahmonberdiyeva, Matluba

Халқаро илмий педиатрия журнали · 2026-yil

Annotatsiya

Introduction. Chronic kidney disease in children is accompanied by pronounced metabolic, hormonal, and inflammatory disturbances, among which alterations in thyroid status occupy an important place. As renal function declines, peripheral thyroid hormone metabolism becomes impaired, iodine clearance decreases, chronic inflammation intensifies, and the likelihood of developing a biochemical profile consistent with low T3 syndrome increases. Aim. To summarize current evidence on thyroid dysfunction in children with chronic kidney disease and to analyze the main pathogenetic mechanisms, laboratory abnormalities, and clinical significance of thyroid status alterations in this patient population. Materials and methods. This study was conducted as a narrative literature review. Recent publications on chronic kidney disease in children, thyroid profile abnormalities associated with reduced renal function, the pathogenetic mechanisms of low T3 syndrome, and the clinical significance of hormonal disturbances in this patient population were reviewed and analyzed. Results and discussion. Thyroid dysfunction in children with chronic kidney disease does not always reflect primary thyroid pathology, as it often develops secondary to uremic intoxication, impaired deiodinase activity, chronic inflammation with activation of proinflammatory cytokines, protein-energy deficiency, and metabolic disturbances. The most common hormonal abnormality is low T3 syndrome, which should be regarded as one of the markers of systemic metabolic maladaptation in chronic kidney disease. In childhood, these changes are of particular clinical importance because they may be associated with growth retardation, impaired nutritional status, abnormalities of bone metabolism, and reduced adaptive capacity. Conclusion. Thyroid dysfunction in children with chronic kidney disease is a clinically significant manifestation of systemic disorders and requires comprehensive assessment during follow-up, especially in patients with growth retardation, malnutrition, and a marked decline in renal function.

Maqola ma’lumotlari
MualliflarKarimdzhanov, Ilkhamdzhan, Rahmonberdiyeva, Matluba, Илхамджан, Рахмонбердиева, Матлуба, Karimdjanov, Ilxamdjan, Rahmonberdiyeva, Matluba
JurnalХалқаро илмий педиатрия журнали
NashriyotАндижон давлат тиббиёт институти; In Science МЧЖ
ISSN2181-2926, 2181-2926
Nashr sanasi2026-04-28
Jild5
Son2
Betlar1296-1301
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-2926-2026-5-2-1296-1301
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-2926-2026-5-2-1296-1301 · Maqolaning asl sahifasi

Kalit so‘zlar

children, chronic kidney disease, thyroid dysfunction, low T3 syndrome, hypothyroidism, pediatric nephrology, дети, хроническая болезнь почек, тиреоидная дисфункция, синдром низкого T3, гипотиреоз, bolalar, surunkali buyrak kasalligi, qalqonsimon bez disfunktsiyasi, past T3 sindromi, gipotireoz

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKarimdzhanov, Ilkhamdzhan, Rahmonberdiyeva, Matluba, Илхамджан, Рахмонбердиева, Матлуба, Karimdjanov, Ilxamdjan, & Rahmonberdiyeva, Matluba (2026). Thyroid Gland and Chronic Kidney Disease in Children. Халқаро илмий педиатрия журнали, 5(2), 1296-1301. https://doi.org/10.56121/2181-2926-2026-5-2-1296-1301
GOST (OAK)Karimdzhanov, Ilkhamdzhan va b. Thyroid Gland and Chronic Kidney Disease in Children // Халқаро илмий педиатрия журнали. – 2026. – T. 5, № 2. – P. 1296-1301. – DOI: 10.56121/2181-2926-2026-5-2-1296-1301.
MLAKarimdzhanov, Ilkhamdzhan, Rahmonberdiyeva, Matluba, Илхамджан, Рахмонбердиева, Матлуба, Karimdjanov, Ilxamdjan, and Rahmonberdiyeva, Matluba. “Thyroid Gland and Chronic Kidney Disease in Children.” Халқаро илмий педиатрия журнали, 5(2), 1296-1301, 2026. https://doi.org/10.56121/2181-2926-2026-5-2-1296-1301
ChicagoKarimdzhanov, Ilkhamdzhan, Rahmonberdiyeva, Matluba, Илхамджан, Рахмонбердиева, Матлуба, Karimdjanov, Ilxamdjan, and Rahmonberdiyeva, Matluba. “Thyroid Gland and Chronic Kidney Disease in Children.” Халқаро илмий педиатрия журнали, 5(2), 1296-1301 (2026). https://doi.org/10.56121/2181-2926-2026-5-2-1296-1301
HarvardKarimdzhanov, Ilkhamdzhan, Rahmonberdiyeva, Matluba, Илхамджан, Рахмонбердиева, Матлуба, Karimdjanov, Ilxamdjan, and Rahmonberdiyeva, Matluba (2026) ‘Thyroid Gland and Chronic Kidney Disease in Children’, Халқаро илмий педиатрия журнали, 5(2), 1296-1301. https://doi.org/10.56121/2181-2926-2026-5-2-1296-1301
BibTeX
@article{karimdzhanovilkhamdzhan2026,
  title = {Thyroid Gland and Chronic Kidney Disease in Children},
  author = {Karimdzhanov, Ilkhamdzhan and Rahmonberdiyeva, Matluba and Илхамджан and Рахмонбердиева, Матлуба and Karimdjanov, Ilxamdjan and Rahmonberdiyeva, Matluba},
  journal = {Халқаро илмий педиатрия журнали},
  year = {2026},
  volume = {5},
  number = {2},
  pages = {1296-1301},
  doi = {10.56121/2181-2926-2026-5-2-1296-1301},
  url = {https://doi.org/10.56121/2181-2926-2026-5-2-1296-1301}
}

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