Bronchial Asthma in Adolescents with Undifferentiated Connective Tissue Dysplasia: Role of Th17 Cytokines, Vitamin D and Microelement Imbalance

Abdullaeva, Dilorom, Shomuradova, Kamila, Sаidkhonova, Adibakhon, Tursunaliev, Sukhrobzhon, Adkhamova, Sabina, Mansurov, Jahongir, Pulatova, Barnoxon, Абдуллаева, Дилорам, Шомурадова, Камила, Саидхонова, Адибахон, Турсуналиев, Сухробжон, Адхамова, Сабина, Мансуров, Джахонгир, Пулатова, Барнохон, Abdullaeva, Dilorom, Shomuradova, Kamila, Sаidkhonova, Adibakhon, Tursunaliev, Sukhrobzhon, Adkhamova, Sabina, Mansurov, Jahongir, Pulatova, Barnoxon

Халқаро илмий педиатрия журнали · 2026-yil

Annotatsiya

Introduction. Bronchial asthma is a chronic inflammatory disease of the airways characterized by bronchial hyperreactivity and airway remodeling. In recent years, increasing attention has been paid to the role of undifferentiated connective tissue dysplasia (UCTD) in the development and progression of bronchial asthma in adolescents. Structural abnormalities of connective tissue may contribute to changes in the architecture of the bronchial wall, enhancement of inflammatory processes, and worsening of the clinical course of the disease. Aim of the study. To evaluate the role of Th17 cytokines (IL-17), transforming growth factor-β (TGF-β), vitamin D status, and the balance of trace elements (zinc and magnesium) in adolescents with bronchial asthma associated with undifferentiated connective tissue dysplasia. Material and methods. The study included 182 adolescents aged 12–17 years. The main group consisted of patients with bronchial asthma combined with UCTD (n=92), the comparison group included patients with bronchial asthma without UCTD (n=60), and the control group consisted of practically healthy adolescents (n=30). Clinical, laboratory, immunological and biochemical methods of investigation were used. The levels of IL-17, TGF-β, IgE, vitamin D, zinc, and magnesium were assessed. Results and discussion. Adolescents with bronchial asthma associated with UCTD demonstrated significantly higher levels of IL-17, TGF-β and IgE, as well as significantly lower levels of vitamin D, zinc and magnesium compared with the control group (p<0.05). Multivariate regression analysis revealed that elevated IL-17 levels and vitamin D deficiency were independent predictors of severe bronchial asthma. These findings indicate the involvement of immune dysregulation and connective tissue abnormalities in the processes of airway remodeling and disease progression. Conclusion. The obtained results suggest that adolescents with bronchial asthma associated with UCTD have pronounced immune and metabolic disturbances, which may contribute to the severity of the disease and its progression. Assessment of cytokine profile, vitamin D status, and trace element balance may be important for improving the diagnosis and management of bronchial asthma in this group of patients.

Maqola ma’lumotlari
MualliflarAbdullaeva, Dilorom, Shomuradova, Kamila, Sаidkhonova, Adibakhon, Tursunaliev, Sukhrobzhon, Adkhamova, Sabina, Mansurov, Jahongir, Pulatova, Barnoxon, Абдуллаева, Дилорам, Шомурадова, Камила, Саидхонова, Адибахон, Турсуналиев, Сухробжон, Адхамова, Сабина, Мансуров, Джахонгир, Пулатова, Барнохон, Abdullaeva, Dilorom, Shomuradova, Kamila, Sаidkhonova, Adibakhon, Tursunaliev, Sukhrobzhon, Adkhamova, Sabina, Mansurov, Jahongir, Pulatova, Barnoxon
JurnalХалқаро илмий педиатрия журнали
NashriyotАндижон давлат тиббиёт институти; In Science МЧЖ
ISSN2181-2926, 2181-2926
Nashr sanasi2026-04-29
Jild5
Son2
Betlar1285-1289
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-2926-2026-5-2-1285-1289
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-2926-2026-5-2-1285-1289 · Maqolaning asl sahifasi

Kalit so‘zlar

bronchial asthma, undifferentiated connective tissue dysplasia, IL-17, amin D deficiency, adolescents, бронхиальная астма, недифференцированная дисплазия соединительной ткани, IL-17, дефицит витамина D, подростки, astma, differentsiatsiyalanmagan biriktiruvchi to'qima displaziyasi, IL-17, D vitamini yetishmovchiligi, o'smirlar

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAbdullaeva, Dilorom, Shomuradova, Kamila, Sаidkhonova, Adibakhon, Tursunaliev, Sukhrobzhon, Adkhamova, Sabina, Mansurov, Jahongir, Pulatova, Barnoxon, Абдуллаева, Дилорам, Шомурадова, Камила, Саидхонова, Адибахон, Турсуналиев, Сухробжон, Адхамова, Сабина, Мансуров, Джахонгир, Пулатова, Барнохон, Abdullaeva, Dilorom, Shomuradova, Kamila, Sаidkhonova, Adibakhon, Tursunaliev, Sukhrobzhon, Adkhamova, Sabina, Mansurov, Jahongir, & Pulatova, Barnoxon (2026). Bronchial Asthma in Adolescents with Undifferentiated Connective Tissue Dysplasia: Role of Th17 Cytokines, Vitamin D and Microelement Imbalance. Халқаро илмий педиатрия журнали, 5(2), 1285-1289. https://doi.org/10.56121/2181-2926-2026-5-2-1285-1289
GOST (OAK)Abdullaeva, Dilorom va b. Bronchial Asthma in Adolescents with Undifferentiated Connective Tissue Dysplasia: Role of Th17 Cytokines, Vitamin D and Microelement Imbalance // Халқаро илмий педиатрия журнали. – 2026. – T. 5, № 2. – P. 1285-1289. – DOI: 10.56121/2181-2926-2026-5-2-1285-1289.
MLAAbdullaeva, Dilorom, Shomuradova, Kamila, Sаidkhonova, Adibakhon, Tursunaliev, Sukhrobzhon, Adkhamova, Sabina, Mansurov, Jahongir, Pulatova, Barnoxon, Абдуллаева, Дилорам, Шомурадова, Камила, Саидхонова, Адибахон, Турсуналиев, Сухробжон, Адхамова, Сабина, Мансуров, Джахонгир, Пулатова, Барнохон, Abdullaeva, Dilorom, Shomuradova, Kamila, Sаidkhonova, Adibakhon, Tursunaliev, Sukhrobzhon, Adkhamova, Sabina, Mansurov, Jahongir, and Pulatova, Barnoxon. “Bronchial Asthma in Adolescents with Undifferentiated Connective Tissue Dysplasia: Role of Th17 Cytokines, Vitamin D and Microelement Imbalance.” Халқаро илмий педиатрия журнали, 5(2), 1285-1289, 2026. https://doi.org/10.56121/2181-2926-2026-5-2-1285-1289
ChicagoAbdullaeva, Dilorom, Shomuradova, Kamila, Sаidkhonova, Adibakhon, Tursunaliev, Sukhrobzhon, Adkhamova, Sabina, Mansurov, Jahongir, Pulatova, Barnoxon, Абдуллаева, Дилорам, Шомурадова, Камила, Саидхонова, Адибахон, Турсуналиев, Сухробжон, Адхамова, Сабина, Мансуров, Джахонгир, Пулатова, Барнохон, Abdullaeva, Dilorom, Shomuradova, Kamila, Sаidkhonova, Adibakhon, Tursunaliev, Sukhrobzhon, Adkhamova, Sabina, Mansurov, Jahongir, and Pulatova, Barnoxon. “Bronchial Asthma in Adolescents with Undifferentiated Connective Tissue Dysplasia: Role of Th17 Cytokines, Vitamin D and Microelement Imbalance.” Халқаро илмий педиатрия журнали, 5(2), 1285-1289 (2026). https://doi.org/10.56121/2181-2926-2026-5-2-1285-1289
HarvardAbdullaeva, Dilorom, Shomuradova, Kamila, Sаidkhonova, Adibakhon, Tursunaliev, Sukhrobzhon, Adkhamova, Sabina, Mansurov, Jahongir, Pulatova, Barnoxon, Абдуллаева, Дилорам, Шомурадова, Камила, Саидхонова, Адибахон, Турсуналиев, Сухробжон, Адхамова, Сабина, Мансуров, Джахонгир, Пулатова, Барнохон, Abdullaeva, Dilorom, Shomuradova, Kamila, Sаidkhonova, Adibakhon, Tursunaliev, Sukhrobzhon, Adkhamova, Sabina, Mansurov, Jahongir, and Pulatova, Barnoxon (2026) ‘Bronchial Asthma in Adolescents with Undifferentiated Connective Tissue Dysplasia: Role of Th17 Cytokines, Vitamin D and Microelement Imbalance’, Халқаро илмий педиатрия журнали, 5(2), 1285-1289. https://doi.org/10.56121/2181-2926-2026-5-2-1285-1289
BibTeX
@article{abdullaevadilorom2026,
  title = {Bronchial Asthma in Adolescents with Undifferentiated Connective Tissue Dysplasia: Role of Th17 Cytokines, Vitamin D and Microelement Imbalance},
  author = {Abdullaeva, Dilorom and Shomuradova, Kamila and Sаidkhonova, Adibakhon and Tursunaliev, Sukhrobzhon and Adkhamova, Sabina and Mansurov, Jahongir and Pulatova, Barnoxon and Абдуллаева, Дилорам and Шомурадова, Камила and Саидхонова, Адибахон and Турсуналиев, Сухробжон and Адхамова, Сабина and Мансуров, Джахонгир and Пулатова, Барнохон and Abdullaeva, Dilorom and Shomuradova, Kamila and Sаidkhonova, Adibakhon and Tursunaliev, Sukhrobzhon and Adkhamova, Sabina and Mansurov, Jahongir and Pulatova, Barnoxon},
  journal = {Халқаро илмий педиатрия журнали},
  year = {2026},
  volume = {5},
  number = {2},
  pages = {1285-1289},
  doi = {10.56121/2181-2926-2026-5-2-1285-1289},
  url = {https://doi.org/10.56121/2181-2926-2026-5-2-1285-1289}
}

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