Features of t-helper immune response in young children with congenital cleft lip and palate in acute pneumonia

Aliev, Akhmadjon, Kamalov, Zaynitdin, Akhrorkhonov, Rustamkhon, Алиев, Ахмаджон, Камалов, Зайнитдин, Ахрорхонов, Рустамхон, Aliev, Axmadjon, Kamalov, Zaynitdin, Axrorxonov, Rustamxon

Халқаро илмий педиатрия журнали · 2025-yil

Annotatsiya

А significant proportion of children with repeated acute respiratory infections (ARI) and recurrent chronic diseases of the respiratory tract and ENT organs are carriers of co-infections. Objective: to study the synthesis of key cytokines Th-1/ Th-2/ Th-17 types of immune responses in children with congenital cleft lip and palate in acute pneumonia. Material and methods: the present study included 38 children with an established diagnosis of acute pneumonia (18 infants with CCLP and 20 children without CCLP formed the comparison group) and 16 practically healthy children formed the control group. The concentration of interleukins and interferon-gamma in the blood serum was determined by solid-phase enzyme immunoassay using test systems of Vector-Best JSC (Novosibirsk, Russia). Results: It was found that in the groups of children with pneumonia, both with cleft lip and palate and without congenital pathology, there was a significant increase in the content of IL-17A, IL-4 in the peripheral blood and a deficiency of IFN-γ in children of the first year of life, which indicates an imbalance in the immune response that can affect the course and severity of the infection. Conclusions: The study of the cytokine profile in a comparative aspect revealed hypersecretion of key mediators of the Th2 and Th17 immune response (IL-4 and IL-17A) and a deficiency in the synthesis of the key antiviral cytokine Th1 immune response (IFN γ) in all groups of children with pneumonia.

Maqola ma’lumotlari
MualliflarAliev, Akhmadjon, Kamalov, Zaynitdin, Akhrorkhonov, Rustamkhon, Алиев, Ахмаджон, Камалов, Зайнитдин, Ахрорхонов, Рустамхон, Aliev, Axmadjon, Kamalov, Zaynitdin, Axrorxonov, Rustamxon
JurnalХалқаро илмий педиатрия журнали
NashriyotАндижон давлат тиббиёт институти; In Science МЧЖ
ISSN2181-2926, 2181-2926
Nashr sanasi2025-02-25
Jild4
Son1
Betlar837-842
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-2926-2025-4-1-837-842
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-2926-2025-4-1-837-842 · Maqolaning asl sahifasi

Kalit so‘zlar

младенцы, расщелины губы и неба, пневмония, интерферон, интерлейкин, сыворотка, дисбаланс, infants, cleft lip and palate, pneumonia, interferon, interleukin, serum, imbalance, chaqaloqlar, lab va tanglay yorig'i, pnevmoniya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAliev, Akhmadjon, Kamalov, Zaynitdin, Akhrorkhonov, Rustamkhon, Алиев, Ахмаджон, Камалов, Зайнитдин, Ахрорхонов, Рустамхон, Aliev, Axmadjon, Kamalov, Zaynitdin, & Axrorxonov, Rustamxon (2025). FEATURES OF T-HELPER IMMUNE RESPONSE IN YOUNG CHILDREN WITH CONGENITAL CLEFT LIP AND PALATE IN ACUTE PNEUMONIA. Халқаро илмий педиатрия журнали, 4(1), 837-842. https://doi.org/10.56121/2181-2926-2025-4-1-837-842
GOST (OAK)Aliev, Akhmadjon va b. FEATURES OF T-HELPER IMMUNE RESPONSE IN YOUNG CHILDREN WITH CONGENITAL CLEFT LIP AND PALATE IN ACUTE PNEUMONIA // Халқаро илмий педиатрия журнали. – 2025. – T. 4, № 1. – P. 837-842. – DOI: 10.56121/2181-2926-2025-4-1-837-842.
MLAAliev, Akhmadjon, Kamalov, Zaynitdin, Akhrorkhonov, Rustamkhon, Алиев, Ахмаджон, Камалов, Зайнитдин, Ахрорхонов, Рустамхон, Aliev, Axmadjon, Kamalov, Zaynitdin, and Axrorxonov, Rustamxon. “FEATURES OF T-HELPER IMMUNE RESPONSE IN YOUNG CHILDREN WITH CONGENITAL CLEFT LIP AND PALATE IN ACUTE PNEUMONIA.” Халқаро илмий педиатрия журнали, 4(1), 837-842, 2025. https://doi.org/10.56121/2181-2926-2025-4-1-837-842
ChicagoAliev, Akhmadjon, Kamalov, Zaynitdin, Akhrorkhonov, Rustamkhon, Алиев, Ахмаджон, Камалов, Зайнитдин, Ахрорхонов, Рустамхон, Aliev, Axmadjon, Kamalov, Zaynitdin, and Axrorxonov, Rustamxon. “FEATURES OF T-HELPER IMMUNE RESPONSE IN YOUNG CHILDREN WITH CONGENITAL CLEFT LIP AND PALATE IN ACUTE PNEUMONIA.” Халқаро илмий педиатрия журнали, 4(1), 837-842 (2025). https://doi.org/10.56121/2181-2926-2025-4-1-837-842
HarvardAliev, Akhmadjon, Kamalov, Zaynitdin, Akhrorkhonov, Rustamkhon, Алиев, Ахмаджон, Камалов, Зайнитдин, Ахрорхонов, Рустамхон, Aliev, Axmadjon, Kamalov, Zaynitdin, and Axrorxonov, Rustamxon (2025) ‘FEATURES OF T-HELPER IMMUNE RESPONSE IN YOUNG CHILDREN WITH CONGENITAL CLEFT LIP AND PALATE IN ACUTE PNEUMONIA’, Халқаро илмий педиатрия журнали, 4(1), 837-842. https://doi.org/10.56121/2181-2926-2025-4-1-837-842
BibTeX
@article{alievakhmadjon2025,
  title = {FEATURES OF T-HELPER IMMUNE RESPONSE IN YOUNG CHILDREN WITH CONGENITAL CLEFT LIP AND PALATE IN ACUTE PNEUMONIA},
  author = {Aliev, Akhmadjon and Kamalov, Zaynitdin and Akhrorkhonov, Rustamkhon and Алиев, Ахмаджон and Камалов, Зайнитдин and Ахрорхонов, Рустамхон and Aliev, Axmadjon and Kamalov, Zaynitdin and Axrorxonov, Rustamxon},
  journal = {Халқаро илмий педиатрия журнали},
  year = {2025},
  volume = {4},
  number = {1},
  pages = {837-842},
  doi = {10.56121/2181-2926-2025-4-1-837-842},
  url = {https://doi.org/10.56121/2181-2926-2025-4-1-837-842}
}

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