The role of intestinal microflora in the development of gallstone disease (literature review)

Агабабян Ирина Рубеновна, Хохлачева Наталья Александровна

Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali · 2025-yil

Annotatsiya

Cholelithiasis is one of the most common diseases of the digestive system, which affects all segments of the population. Currently, cholelithiasis is seen as a long, multi-stage process in which the period of stone formation is preceded by changes in metabolism and physical and chemical properties of bile. However, among the many contributing factors, insufficient attention is paid to the role of the infectious factor in the development of cholelithiasis. The analysis of the literature data showed that today there are various mechanisms for promoting development of cholelithiasis by excess enteral bacterial growth. First, with excessive bacterial growth, duodena-biliary reflux leads to infection of the biliary tract and the development of inflammation in the gallbladder. Substances that occur during the inflammatory process (proteins, mucus, exfoliated epithelium) are the matrix on which the gallstone is formed. Secondly, the role of dysbiosis in violation of enterohepatic circulation of bile acids is essential. The change in the ratio of conjugated and deconjugated bile acids contributes to the formation of lithogenic bile. Thirdly, excessive bacterial growth leads to endotoxemia, which has a damaging effect on the metabolism of bile acids in the liver. Finally, the digestive and suction functions of the small intestine are in a certain dependence on the microbiota, but the participation of this channel in cholelithiasis requires further research.

Maqola ma’lumotlari
MualliflarАгабабян Ирина Рубеновна, Хохлачева Наталья Александровна
JurnalJournal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali
NashriyotСамарқанд давлат тиббиёт университети
Nashr sanasi2025-06-10
Jild6
Son2/1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

желчнокаменная болезнь, энтерогепатическая циркуляция желчных кислот, эндотоксинемия. избыточный бактериальный рост, кишечная аритмия, cholelithiasis, enterohepatic circulation of bile acids, endotoxinemia. excessive bacterial growth, gallstone disease, intestinal arrhythmia, xolelitiaz, o‘t kislotalarining enterogepatik aylanishi, endotoksemiya, bakteriyalarning ortiqcha o‘sishi, o‘t-tosh kasalligi, ichak diskineziyasi

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAАгабабян Ирина Рубеновна, & Хохлачева Наталья Александровна (2025). THE ROLE OF INTESTINAL MICROFLORA IN THE DEVELOPMENT OF GALLSTONE DISEASE (LITERATURE REVIEW). Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2/1). https://www.tadqiqot.uz/index.php/cardio/article/view/11511
GOST (OAK)Агабабян Ирина Рубеновна, Хохлачева Наталья Александровна THE ROLE OF INTESTINAL MICROFLORA IN THE DEVELOPMENT OF GALLSTONE DISEASE (LITERATURE REVIEW) // Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali. – 2025. – T. 6, № 2/1.
MLAАгабабян Ирина Рубеновна, and Хохлачева Наталья Александровна. “THE ROLE OF INTESTINAL MICROFLORA IN THE DEVELOPMENT OF GALLSTONE DISEASE (LITERATURE REVIEW).” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2/1), 2025. https://www.tadqiqot.uz/index.php/cardio/article/view/11511
ChicagoАгабабян Ирина Рубеновна, and Хохлачева Наталья Александровна. “THE ROLE OF INTESTINAL MICROFLORA IN THE DEVELOPMENT OF GALLSTONE DISEASE (LITERATURE REVIEW).” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2/1) (2025). https://www.tadqiqot.uz/index.php/cardio/article/view/11511
HarvardАгабабян Ирина Рубеновна, and Хохлачева Наталья Александровна (2025) ‘THE ROLE OF INTESTINAL MICROFLORA IN THE DEVELOPMENT OF GALLSTONE DISEASE (LITERATURE REVIEW)’, Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2/1). https://www.tadqiqot.uz/index.php/cardio/article/view/11511
BibTeX
@article{article2025,
  title = {THE ROLE OF INTESTINAL MICROFLORA IN THE DEVELOPMENT OF GALLSTONE DISEASE (LITERATURE REVIEW)},
  author = {Агабабян Ирина Рубеновна and Хохлачева Наталья Александровна},
  journal = {Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali},
  year = {2025},
  volume = {6},
  number = {2/1},
  url = {https://www.tadqiqot.uz/index.php/cardio/article/view/11511}
}

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