Interrelationship of clinical, immunological, and metabolic factors in the development of type 1 diabetes (literature review)

Негматова Гулзода Шухратовна, Рузимуродов Нодир Фазлиддинович, Саидвалиева Саодат Алимжановна

Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali · 2025-yil

Annotatsiya

Type 1 diabetes (T1D) is a chronic autoimmune disease in which the immune system mistakenly attacks pancreatic β-cells, leading to their destruction and absolute insulin deficiency. As a result, severe hyperglycemia develops, causing systemic metabolic disorders. This review analyzes the key aspects of T1D pathogenesis, including clinical manifestations, immune mechanisms, and metabolic consequences. Special attention is given to the role of genetic factors, the interaction between the immune system and metabolic processes, as well as modern diagnostic methods and new therapeutic strategies. The article discusses recent research aimed at identifying early diagnostic biomarkers, including autoantibodies and pro-inflammatory cytokines, as well as promising treatment approaches such as immunotherapy, cell therapy, and the influence of gut microbiota on disease progression. Despite significant progress in understanding T1D pathogenesis, several unresolved issues remain, requiring further investigation, particularly the mechanisms of interaction between immune and metabolic processes and the potential for early interventions that could slow disease progression.

Maqola ma’lumotlari
MualliflarНегматова Гулзода Шухратовна, Рузимуродов Нодир Фазлиддинович, Саидвалиева Саодат Алимжановна
JurnalJournal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali
NashriyotСамарқанд давлат тиббиёт университети
Nashr sanasi2025-06-10
Jild6
Son2/1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

сахарный диабет 1 типа, аутоиммунное воспаление, β-клетки, метаболические нарушения, иммунотерапия, биомаркеры, микробиота кишечника, type 1 diabetes, autoimmune inflammation, β-cells, metabolic disorders, immunotherapy, biomarkers, gut microbiota, tur qandli diabet, avtoimmun yallig‘lanish, β-hujayralar, metabolik buzilishlar, immunoterapiya, biobelgilar, ichak mikrobiotasi

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAНегматова Гулзода Шухратовна, Рузимуродов Нодир Фазлиддинович, & Саидвалиева Саодат Алимжановна (2025). INTERRELATIONSHIP OF CLINICAL, IMMUNOLOGICAL, AND METABOLIC FACTORS IN THE DEVELOPMENT OF TYPE 1 DIABETES (LITERATURE REVIEW). Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2/1). https://www.tadqiqot.uz/index.php/cardio/article/view/11508
GOST (OAK)Негматова Гулзода Шухратовна, Рузимуродов Нодир Фазлиддинович, Саидвалиева Саодат Алимжановна INTERRELATIONSHIP OF CLINICAL, IMMUNOLOGICAL, AND METABOLIC FACTORS IN THE DEVELOPMENT OF TYPE 1 DIABETES (LITERATURE REVIEW) // Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali. – 2025. – T. 6, № 2/1.
MLAНегматова Гулзода Шухратовна, Рузимуродов Нодир Фазлиддинович, and Саидвалиева Саодат Алимжановна. “INTERRELATIONSHIP OF CLINICAL, IMMUNOLOGICAL, AND METABOLIC FACTORS IN THE DEVELOPMENT OF TYPE 1 DIABETES (LITERATURE REVIEW).” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2/1), 2025. https://www.tadqiqot.uz/index.php/cardio/article/view/11508
ChicagoНегматова Гулзода Шухратовна, Рузимуродов Нодир Фазлиддинович, and Саидвалиева Саодат Алимжановна. “INTERRELATIONSHIP OF CLINICAL, IMMUNOLOGICAL, AND METABOLIC FACTORS IN THE DEVELOPMENT OF TYPE 1 DIABETES (LITERATURE REVIEW).” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2/1) (2025). https://www.tadqiqot.uz/index.php/cardio/article/view/11508
HarvardНегматова Гулзода Шухратовна, Рузимуродов Нодир Фазлиддинович, and Саидвалиева Саодат Алимжановна (2025) ‘INTERRELATIONSHIP OF CLINICAL, IMMUNOLOGICAL, AND METABOLIC FACTORS IN THE DEVELOPMENT OF TYPE 1 DIABETES (LITERATURE REVIEW)’, Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2/1). https://www.tadqiqot.uz/index.php/cardio/article/view/11508
BibTeX
@article{article2025,
  title = {INTERRELATIONSHIP OF CLINICAL, IMMUNOLOGICAL, AND METABOLIC FACTORS IN THE DEVELOPMENT OF TYPE 1 DIABETES (LITERATURE REVIEW)},
  author = {Негматова Гулзода Шухратовна and Рузимуродов Нодир Фазлиддинович and Саидвалиева Саодат Алимжановна},
  journal = {Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali},
  year = {2025},
  volume = {6},
  number = {2/1},
  url = {https://www.tadqiqot.uz/index.php/cardio/article/view/11508}
}

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