Early molecular and immune markers as a basis for differentiated therapy of type 2 autoimmune polyglandular syndrome (literature review)

Арипова Тамара Уктамовна, Негматова Гулзода Шухратовна, Халимова Замира Юсуповна

Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali · 2025-yil

Annotatsiya

Type 2 autoimmune polyglandular syndrome (APS-2) is a complex endocrine disorder characterized by a combination of autoimmune pathologies, such as Addison’s disease, autoimmune thyroiditis, and type 1 diabetes mellitus. Despite significant progress in the study of APS-2, its pathogenesis, diagnosis, and therapy remain relevant research areas. This literature review examines modern molecular and immune markers that play a key role in the early detection and prognosis of the disease. Genetic predispositions, including HLA-DR3 and HLA-DR4 alleles, as well as polymorphisms in the CTLA-4, PTPN22, FOXP3, and STAT4 genes, are analyzed. Special attention is paid to epigenetic factors such as DNA methylation and the influence of non-coding RNAs on immune mechanisms. Key immune markers, including autoantibodies to 21-hydroxylase, GAD65, and IA-2, as well as the role of pro-inflammatory cytokines and changes in the T-lymphocyte population, are considered. The review highlights prospects for differentiated therapy, including targeted monoclonal antibodies, antigen-specific immunotherapy, cellular technologies, and metabolic regulation. Further research into APS-2 mechanisms will contribute to the improvement of diagnostic and therapeutic approaches, enhancing the effectiveness of personalized medicine in endocrinology.

Maqola ma’lumotlari
MualliflarАрипова Тамара Уктамовна, Негматова Гулзода Шухратовна, Халимова Замира Юсуповна
JurnalJournal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali
NashriyotСамарқанд давлат тиббиёт университети
Nashr sanasi2025-06-04
Jild6
Son2/4
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

аутоиммунный полигландулярный синдром 2 типа, аутоантитела, таргетная терапия, иммуномодуляция, персонализированная медицина, type 2 autoimmune polyglandular syndrome, autoantibodies, targeted therapy, immunomodulation, personalized medicine, 2-tur avtoimmun poliglandulyar sindrom, avtoantitanalar, nishonga yo‘naltirilgan terapiya, immunomodulyatsiya, shaxsga yo‘naltirilgan tibbiyot

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAАрипова Тамара Уктамовна, Негматова Гулзода Шухратовна, & Халимова Замира Юсуповна (2025). EARLY MOLECULAR AND IMMUNE MARKERS AS A BASIS FOR DIFFERENTIATED THERAPY OF TYPE 2 AUTOIMMUNE POLYGLANDULAR SYNDROME (LITERATURE REVIEW). Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2/4). https://www.tadqiqot.uz/index.php/cardio/article/view/11463
GOST (OAK)Арипова Тамара Уктамовна, Негматова Гулзода Шухратовна, Халимова Замира Юсуповна EARLY MOLECULAR AND IMMUNE MARKERS AS A BASIS FOR DIFFERENTIATED THERAPY OF TYPE 2 AUTOIMMUNE POLYGLANDULAR SYNDROME (LITERATURE REVIEW) // Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali. – 2025. – T. 6, № 2/4.
MLAАрипова Тамара Уктамовна, Негматова Гулзода Шухратовна, and Халимова Замира Юсуповна. “EARLY MOLECULAR AND IMMUNE MARKERS AS A BASIS FOR DIFFERENTIATED THERAPY OF TYPE 2 AUTOIMMUNE POLYGLANDULAR SYNDROME (LITERATURE REVIEW).” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2/4), 2025. https://www.tadqiqot.uz/index.php/cardio/article/view/11463
ChicagoАрипова Тамара Уктамовна, Негматова Гулзода Шухратовна, and Халимова Замира Юсуповна. “EARLY MOLECULAR AND IMMUNE MARKERS AS A BASIS FOR DIFFERENTIATED THERAPY OF TYPE 2 AUTOIMMUNE POLYGLANDULAR SYNDROME (LITERATURE REVIEW).” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2/4) (2025). https://www.tadqiqot.uz/index.php/cardio/article/view/11463
HarvardАрипова Тамара Уктамовна, Негматова Гулзода Шухратовна, and Халимова Замира Юсуповна (2025) ‘EARLY MOLECULAR AND IMMUNE MARKERS AS A BASIS FOR DIFFERENTIATED THERAPY OF TYPE 2 AUTOIMMUNE POLYGLANDULAR SYNDROME (LITERATURE REVIEW)’, Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2/4). https://www.tadqiqot.uz/index.php/cardio/article/view/11463
BibTeX
@article{article2025,
  title = {EARLY MOLECULAR AND IMMUNE MARKERS AS A BASIS FOR DIFFERENTIATED THERAPY OF TYPE 2 AUTOIMMUNE POLYGLANDULAR SYNDROME (LITERATURE REVIEW)},
  author = {Арипова Тамара Уктамовна and Негматова Гулзода Шухратовна and Халимова Замира Юсуповна},
  journal = {Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali},
  year = {2025},
  volume = {6},
  number = {2/4},
  url = {https://www.tadqiqot.uz/index.php/cardio/article/view/11463}
}

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