Analysis of the relationship of polymorphism of the β2-ADRENORECEPTOR gene to bronchial asthma forms as well as indicators of external respiratory activity

Турдибеков Хусан Ибрагимович, Кулиева Гулжахон Бахрановна, Суюнова Гульшан Ураковна, Алламуродов Жахонгир Уролович, Холмамедова Соджида Шодиевна

Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali · 2025-yil

Annotatsiya

Although significant progress has been made in the diagnosis and treatment of bronchial asthma (BA), the variety of forms of the disease, severe withdrawal options and responses to individual treatment leave it as one of the pressing problems in the health system. Research objective. To assess how the ADRB2 gene is distributed in the different phenotypes of the Gln27Glu Polymorph locus BA, and to determine to what extent the most basic parameters of external respiratory function are associated with this polymorphism. Research material and methods: 120 people of Uzbek nationality were examined in order to learn that the Gln27Glu polymorphism of the ADRB2 gene is associated with various pathogenetic variants of Ba, the main indicators of their external respiratory activity, 80 of them patients with BA. Results of the study: the results of the study of the genotype ADRB2 Gene Gln27Gln in allergic BA (ABA) patients found that the frequency of the homozygous variant of the gene being examined in this group of patients was reliably higher than in the control group (73% as well as 44.6%, respectively, χ2=4.7; p<0.05; OR=2.67). Variants of the homozygous genotype Glu27Glu were not observed among ABA patients. Patients with BA with the genotype Gln27Gln were found to respond to salbutamol-induced bronchodilation with a significant increase in FEV1 compared to those with the genotype Gln27Glu and Glu27Glu. Conclusion: in Aba, the ADRB2 gene confirms that the gln27gln genotype, the Gln27 allele, may be an important factor in the development of BA. The greatest increase in FEV₁ in bronchodilating Synapse (salbutamol) was recorded in the genotype Gln27Gln, and the potential for maximum benefit from β₂-agonists was found to be higher in this genotype.

Maqola ma’lumotlari
MualliflarТурдибеков Хусан Ибрагимович, Кулиева Гулжахон Бахрановна, Суюнова Гульшан Ураковна, Алламуродов Жахонгир Уролович, Холмамедова Соджида Шодиевна
JurnalJournal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali
NashriyotСамарқанд давлат тиббиёт университети
Nashr sanasi2025-06-10
Jild6
Son2/1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

бронхиальная астма, полиморфизм гена β2-адренорецептора Gln27Glu, функция внешнего дыхания, сальбутамол, bronchial asthma, Gln27Glu polymorphism of β2-adrenoreceptor gene, external respiratory function, salbutamol, bronxial astma, β2-adrenoreseptor genining Gln27Glu polimorfizmi, tashqi nafas olish funksiyasi, salbutamol

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAТурдибеков Хусан Ибрагимович, Кулиева Гулжахон Бахрановна, Суюнова Гульшан Ураковна, Алламуродов Жахонгир Уролович, & Холмамедова Соджида Шодиевна (2025). ANALYSIS OF THE RELATIONSHIP OF POLYMORPHISM OF THE β2-ADRENORECEPTOR GENE TO BRONCHIAL ASTHMA FORMS AS WELL AS INDICATORS OF EXTERNAL RESPIRATORY ACTIVITY. Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2/1). https://www.tadqiqot.uz/index.php/cardio/article/view/11499
GOST (OAK)Турдибеков Хусан Ибрагимович va b. ANALYSIS OF THE RELATIONSHIP OF POLYMORPHISM OF THE β2-ADRENORECEPTOR GENE TO BRONCHIAL ASTHMA FORMS AS WELL AS INDICATORS OF EXTERNAL RESPIRATORY ACTIVITY // Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali. – 2025. – T. 6, № 2/1.
MLAТурдибеков Хусан Ибрагимович, Кулиева Гулжахон Бахрановна, Суюнова Гульшан Ураковна, Алламуродов Жахонгир Уролович, and Холмамедова Соджида Шодиевна. “ANALYSIS OF THE RELATIONSHIP OF POLYMORPHISM OF THE β2-ADRENORECEPTOR GENE TO BRONCHIAL ASTHMA FORMS AS WELL AS INDICATORS OF EXTERNAL RESPIRATORY ACTIVITY.” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2/1), 2025. https://www.tadqiqot.uz/index.php/cardio/article/view/11499
ChicagoТурдибеков Хусан Ибрагимович, Кулиева Гулжахон Бахрановна, Суюнова Гульшан Ураковна, Алламуродов Жахонгир Уролович, and Холмамедова Соджида Шодиевна. “ANALYSIS OF THE RELATIONSHIP OF POLYMORPHISM OF THE β2-ADRENORECEPTOR GENE TO BRONCHIAL ASTHMA FORMS AS WELL AS INDICATORS OF EXTERNAL RESPIRATORY ACTIVITY.” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2/1) (2025). https://www.tadqiqot.uz/index.php/cardio/article/view/11499
HarvardТурдибеков Хусан Ибрагимович, Кулиева Гулжахон Бахрановна, Суюнова Гульшан Ураковна, Алламуродов Жахонгир Уролович, and Холмамедова Соджида Шодиевна (2025) ‘ANALYSIS OF THE RELATIONSHIP OF POLYMORPHISM OF THE β2-ADRENORECEPTOR GENE TO BRONCHIAL ASTHMA FORMS AS WELL AS INDICATORS OF EXTERNAL RESPIRATORY ACTIVITY’, Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2/1). https://www.tadqiqot.uz/index.php/cardio/article/view/11499
BibTeX
@article{article2025,
  title = {ANALYSIS OF THE RELATIONSHIP OF POLYMORPHISM OF THE β2-ADRENORECEPTOR GENE TO BRONCHIAL ASTHMA FORMS AS WELL AS INDICATORS OF EXTERNAL RESPIRATORY ACTIVITY},
  author = {Турдибеков Хусан Ибрагимович and Кулиева Гулжахон Бахрановна and Суюнова Гульшан Ураковна and Алламуродов Жахонгир Уролович and Холмамедова Соджида Шодиевна},
  journal = {Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali},
  year = {2025},
  volume = {6},
  number = {2/1},
  url = {https://www.tadqiqot.uz/index.php/cardio/article/view/11499}
}

Boshqa maqola uchun iqtibos tayyorlash

Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali jurnalidan boshqa maqolalar

Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali — barcha maqolalar · 2025-yil arxivi

Турдибеков Хусан Ибрагимович — boshqa maqolalari

Tibbiyot sohasidagi boshqa maqolalar

Tibbiyot sohasidagi OAK jurnallari