In order to assess peak inspiratory flow (PIF) in 100 patients with obstructive respiratory pathology as part of the selection of an inhalation device for optimizing inhalation respiratory therapy, a functional study of PIF was conducted using the In-Check DIAL device (Clement Clarke International Ltd., UK) with an imitation of an inhaler of resistance on inspiration, where the device panel took into account the flows: R0 without resistance and 4 levels of resistance, including R1 - low resistance, R2 - medium-low, R3 - medium, R4 - medium-high resistance. The results of the clinical study showed a high proportion of patients (34%-85%) whose peak inspiratory air flow when using inhalers is below the level required for optimal inhalation through inhalation devices with medium-low, medium and medium-high resistance, as a result of which patients receive an insufficient dose of drugs, they experience more frequent exacerbations and hospitalizations compared to patients who are able to create an inhalation flow adequate to the resistance of the inhaler. Suboptimal values of peak inspiratory flow, determined by phenotypic predictors, including female gender, height less than 1.6 m, BMI less than 20 kg/m2 or more than 30 kg/m2, age over 70 years, clinical and functional markers, including the degree of clinical severity of dyspnea according to mMRC more than 3 points, the severity of obstructive disorders FEV1 less than 50% of the expected, and the features of the clinical course, characterized by a high frequency of exacerbations requiring 2 or more hospitalizations, are declared the main component for choosing an inhalation device with optimal resistance, ensuring the effectiveness of therapy for obstructive respiratory pathology, including COPD and asthma, a predictor of treatment effectiveness, optimization of control and a decrease in the frequency of exacerbations requiring frequent hospitalizations. Evaluation of peak inspiratory flow in patients with obstructive respiratory pathology, based on phenotypic, clinical and functional characteristics and variants of the disease course, and its suboptimal peak inspiratory flow in comparison with the level of inhaler resistance can help clinicians to personalize the selection of an inhaler in patients with exacerbation of obstructive respiratory pathology and optimize the choice of an inhalation device in a stable course of the disease.
| Mualliflar | Мамбетниязов Кеунимжай, Ливерко Ирина Владимировна, Абдуганиева Эльнора Абраловна, Гафнер Наталья Владимировна |
|---|---|
| Jurnal | Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali |
| Nashr sanasi | 2024-11-25 |
| Jild | 5 |
| Son | 3 |
| Til | Rus |
пиковый инспираторный поток (ПИП), субоптимальный пиковый инспираторный попок (сПИП), дозированный аэрозольный ингалятор (ДАИ), порошковый ингалятор (ПИ), peak inspiratory flow (PIF), suboptimal peak inspiratory flow (sPIF), metered-dose inhaler (MDI), dry powder inhaler (DPI), eng yuqori nafas olish oqimi (PIF), suboptimal eng yuqori nafas olish oqimi (sPIF), o'lchovli dozali inhaler (MDI), kukunli inhaler (PI)
Along with the increase in the number of patients, an increasing number of them continue to describe symptoms such as fatigue, palpitations, decreased physical activity, shortness of breath, chest pain, neurocognitive…
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease that affects the joints and can lead to destruction of joint tissue, disability and reduced quality of life in patients. Timely diagnosis of RA is…
Combined forms of these pathologies are often the result of the simultaneous manifestation of a number of danger components, the leading of which are considered to be tobacco use, untreated asthma, as well as the…
Objective: To study the factors associated with long-term cardiovascular support after mitral valve replacement (MVR) under artificial circulation (AC). Material and methods: The study included patients who underwent…
In this study, echocardiographic signs of myocardial remodeling were evaluated in patients with acute ST-segment elevation myocardial infarction, depending on the presence of obesity. 91 patients with acute ST-segment…
The aim of the study is to study the daily profile of blood pressure (ABPM) in patients with arterial hypertension (AH) and chronic kidney disease (CKD), depending…
Children's rheumatic diseases refer to a range of musculoskeletal, arthritic, and connective tissue disorders that can develop during childhood. These diseases can affect a child's eyes, joints, skin, muscles, and…
This scientific work reviewed the literature of foreign and national scientific works devoted to coronary artery anomalies. In recent years, the features of the development and course of coronary heart disease, in…
Since the development of thoracic surgery, the organ on which the most advanced operations are performed has been the esophagus. The reasons for this are numerous: anatomical features of the esophagus, features of its…
This scientific work examines the literature of foreign and national scientific papers on the peculiarities of the development and clinical course of coronary heart disease (CHD) in patients with coronary artery…
Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali — barcha maqolalar